Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eunkyung A, Kauh"'
Autor:
Dhananjay D. Marathe, Petra M. Jauslin, Huub Jan Kleijn, Carolina deMiranda Silva, Anne Chain, Thomas Bateman, Peter M. Shaw, Anson K. Abraham, Eunkyung A. Kauh, Yanfang Liu, Rodolfo F. Perini, Dinesh P. deAlwis, Lokesh Jain
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 10, Pp 1499-1510 (2023)
Abstract Belzutifan (Welireg, Merck & Co., Inc., Rahway, NJ, USA) is an oral, potent inhibitor of hypoxia‐inducible factor 2α, approved for the treatment of certain patients with von Hippel–Lindau (VHL) disease‐associated renal cell carcinoma
Externí odkaz:
https://doaj.org/article/9fb57ee9c9224d38a940c36af9575776
Autor:
Douglas G. Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Elisabetta Bianchi, Danila Branca, Paul G. Bulger, Inne Crevecoeur, Fa-Xiang Ding, Robert M. Garbaccio, Erik D. Guetschow, Yan Guo, Sookhee N. Ha, Jennifer M. Johnston, Hubert Josien, Eunkyung A. Kauh, Kenneth A. Koeplinger, Jeffrey T. Kuethe, Eseng Lai, Christine L. Lanning, Anita Y.H. Lee, Li Li, Anilkumar G. Nair, Edward A. O’Neill, S. Aubrey Stoch, David A. Thaisrivongs, Thomas J. Tucker, Petr Vachal, Kristien van Dyck, Frederic P. Vanhoutte, Bram Volckaert, Dennis G. Wolford, Andy Xu, Tian Zhao, Dan Zhou, Susan Zhou, Xiaohong Zhu, Hratch J. Zokian, Abbas Walji, Harold B. Wood
Publikováno v:
Circulation.
Background: Inhibition of PCSK9 (proprotein convertase subtilisin/kexin type 9)-low density lipoprotein receptor interaction with injectable monoclonal antibodies or small interfering RNA lowers plasma low density lipoprotein-cholesterol, but despite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f19bd0c61c330917293f0ae4cf3d908
https://doi.org/10.1161/circulationaha.122.063372
https://doi.org/10.1161/circulationaha.122.063372
Autor:
Carol, Addy, Daniel A, Tatosian, Xiaoli S, Glasgow, Isaias Noel, Gendrano, Christine McCrary, Sisk, Eunkyung A, Kauh, S Aubrey, Stoch, John A, Wagner
Publikováno v:
Clinical pharmacology in drug development. 5(5)
Omarigliptin is being developed as a potent, once-weekly, oral dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. This double-blind, randomized, placebo-controlled study evaluated the effects of age, sex, and obesity on the pharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52cf1306b25519020b1cb704d6d33339
https://pubmed.ncbi.nlm.nih.gov/27627193
https://pubmed.ncbi.nlm.nih.gov/27627193
Publikováno v:
Journal of Biological Chemistry. 272:12091-12099
The antineoplastic alkaloid camptothecin interferes with the catalytic cycle of DNA topoisomerase I rendering it a cellular poison. Camptothecin stabilizes a covalent enzyme-DNA intermediate that is converted into lethal double strand DNA lesions dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f3b7c4f6cbaefe26e7247f081c901e
https://doi.org/10.1074/jbc.272.18.12091
https://doi.org/10.1074/jbc.272.18.12091
Autor:
Mary-Ann Bjornsti, Eunkyung A. Kauh
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(14)
Camptothecin is a potent antineoplastic agent that interferes with the action of eukaryotic DNA topoisomerase I; the covalent enzyme-DNA intermediate is reversibly stabilized, leading to G2 arrest and cell death. We used a genetic screen to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df346eb1107132508d22c2e3ff8f2330
https://pubmed.ncbi.nlm.nih.gov/7603986
https://pubmed.ncbi.nlm.nih.gov/7603986
Autor:
Marathe, Dhananjay D.1 (AUTHOR), Jauslin, Petra M.2 (AUTHOR), Kleijn, Huub Jan2 (AUTHOR), de Miranda Silva, Carolina1 (AUTHOR), Chain, Anne1 (AUTHOR) anne.chain@merck.com, Bateman, Thomas1 (AUTHOR), Shaw, Peter M.1 (AUTHOR), Abraham, Anson K.1 (AUTHOR), Kauh, Eunkyung A.1 (AUTHOR), Liu, Yanfang1 (AUTHOR), Perini, Rodolfo F.1 (AUTHOR), de Alwis, Dinesh P.1 (AUTHOR), Jain, Lokesh1 (AUTHOR)
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. Oct2023, Vol. 12 Issue 10, p1499-1510. 12p.
Autor:
Michael J. Fazio, Zena K. Indik, Joel Rosenbloom, Eunkyung A. Kauh, Clinton T. Baldwin, Jouni Uitto, David R. Olsen, Norma Ornstein-Goldstein, Helena Yeh
Publikováno v:
Journal of Investigative Dermatology. 91(5):458-464
A human cDNA library was constructed utilizing RNA isolated from cultured skin fibroblasts. Recombinant clones containing elastin sequences were identified by plaque hybridizations with previously characterized human placental elastin cDNAs. Seven po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e9e6c9c7d7e4cca7f3db4774cb04f5
Autor:
Johns, Douglas G., Campeau, Louis-Charles, Banka, Puja, Bautmans, An, Bueters, Tjerk, Bianchi, Elisabetta, Branca, Danila, Bulger, Paul G., Crevecoeur, Inne, Ding, Fa-Xiang, Garbaccio, Robert M., Guetschow, Erik D., Guo, Yan, Ha, Sookhee N., Johnston, Jennifer M., Josien, Hubert, Kauh, Eunkyung A., Koeplinger, Kenneth A., Kuethe, Jeffrey T., Lai, Eseng
Publikováno v:
Circulation; 7/11/2023, Vol. 148 Issue 2, p144-158, 15p
Publikováno v:
Clinical Pharmacology & Therapeutics; Jul2022, Vol. 112 Issue 1, p18-23, 6p
Autor:
Addy, Carol1 caddy@hmrboston.com, Tatosian, Daniel A.1, Glasgow, Xiaoli S.1, III, Isaias Noel Gendrano1, Sisk, Christine McCrary1, Kauh, Eunkyung A.1, Stoch, S. Aubrey1, Wagner, John A.1
Publikováno v:
Clinical Pharmacology in Drug Development. Sep/Oct2016, Vol. 5 Issue 5, p374-382. 9p.