Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Eunkyeong Jang"'
Autor:
Kihyoun Park, Injae Shin, Yoonseon Kim, Hyereen Kang, Soo-Jin Oh, Eunkyeong Jang, Taebo Sim, Jeehee Youn, Myung-Shik Lee
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundSince NEK7 is critical for NLRP3 inflammasome activation, NEK7 inhibitors could be employed as therapeutic agents against gout, a representative disease caused by NLRP3 inflammasome.MethodsWe designed NEK7 inhibitors based on biochemical ki
Externí odkaz:
https://doaj.org/article/e54b04d9a99a4f47b6bca4d955a248b0
Publikováno v:
HemaSphere, Vol 7, p e3562913 (2023)
Externí odkaz:
https://doaj.org/article/8f2f8b34e01d41cda9f72b9319db44cc
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022)
Abstract This study aimed to detect safety signals of rebamipide and search for adverse events (AEs) of rebamipide that are more common than those of other drugs for peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) in the elderly
Externí odkaz:
https://doaj.org/article/2ef24c3eca2547d9b8a5fa95cd43ab5c
Autor:
Eunkyeong Jang, Un Kyo Kim, Kiseok Jang, Young Soo Song, Ji-Young Cha, Hansol Yi, Jeehee Youn
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-13 (2019)
Autoimmune disease: Bach2 orchestrates immune function Bach2, a protein that regulates gene expression, is required in the B cells and T cells of the immune system to protect against autoimmune disease. Bach2 deficiency has previously been associated
Externí odkaz:
https://doaj.org/article/693c5dc5fb704e97bbdeb8bbe5dbb7c6
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Splenic long-lived plasma cells are abnormally numerous and deleterious in systemic autoimmune diseases, yet how they accumulate remains poorly understood. We demonstrate here that a pathological role of spleen-derived CD11b+Gr-1+ myeloid cells (SDMC
Externí odkaz:
https://doaj.org/article/063a5337b889454fa6bd5f813e765b4e
Autor:
Eunkyeong Jang, Mini Jeong, Sukhyung Kim, Kiseok Jang, Bo-Kyeong Kang, Dong Yun Lee, Sang-Cheol Bae, Kyung Suk Kim, Jeehee Youn
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to components of the cell nucleus. These autoantibodies are predominantly produced with the help of follicular/helper T (Tfh) cells and form
Externí odkaz:
https://doaj.org/article/85b4aba769b4471e9a1bc7981772d678
Publikováno v:
Clinical and Experimental Immunology. 211:31-45
Spleen tyrosine kinase (Syk) plays a pivotal role in the activation of B cells and innate inflammatory cells by transducing immune receptor-triggered signals. Dysregulated activity of Syk is implicated in the development of antibody-mediated autoimmu
Autor:
Kiseok Jang, Jeehee Youn, Ji-Young Cha, Young Soo Song, Hansol Yi, Un Kyo Kim, Eunkyeong Jang
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 12, Pp 1-13 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Class-switched IgG autoantibodies but not unswitched IgM autoantibodies play a crucial role in the development of systemic lupus erythematosus (SLE). Bach2 is known to be essential for class switch recombination of Ig genes, but recent genomic and cl
Publikováno v:
Immune Network
Long-lasting post-switched plasma cells (PCs) arise mainly from germinal center (GC) reactions, but little is known about the mechanism by which GC B cells differentiate into PCs. Based on our observation that the expression of the transcription fact
Autor:
Geon Hee Lee, Ji-Young Cha, Ah Reum Oh, Eunkyeong Jang, Hye Rim Lee, Kazuhiko Igarashi, Jeehee Youn
Publikováno v:
BMB Reports
The transcription repressor Bach2 has been proposed as a regulator of T cell quiescence, but the underlying mechanism is not fully understood. Given the importance of interleukin-2 in T cell activation, we investigated whether Bach2 is a component of