Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Eunice S. Park"'
Autor:
Stewart L. Fisher, Marta Isasa, Stephen Archer, Heng Li, Mark E. Fitzgerald, Lydia Emerson, Christopher G. Nasveschuk, Linda Lee, Roman V. Agafonov, Richard W. Deibler, Jeffrey R Simard, Ryan E. Michael, Ellen F. Vieux, Brendon Ladd, David A. Proia, Gunther Kern, Eunice S. Park, Andrew J. K. Phillips, David Cocozziello
Publikováno v:
SLAS Discovery. 26:547-559
Recent advances in targeted protein degradation have enabled chemical hijacking of the ubiquitin-proteasome system to treat disease. The catalytic rate of cereblon (CRBN)-dependent bifunctional degradation activating compounds (BiDAC), which recruit
Autor:
Joe Sahil Patel, Eunice S. Park, Chi-Li Chen, Andrew J. K. Phillips, Linda Lee, Thomas G. Scott, Christina S. Henderson, Ashley A. Hart, David A. Proia, James A. Henderson, W. Austin Elam, Catherine S. Oakes, Trang N. Tieu, Joelle Baddour, Mark C. Norley, Mathew E. Sowa, Jessica Freda, Marius S. Pop, Brendon Ladd, Minsheng He, Christopher G. Nasveschuk, Harit U. Vora, Gunther Kern, Gesine Kerstin Veits, Abigail Vogelaar, Stewart L. Fisher, Richard W. Deibler, Rhamy Zeid, Mark W. Carlson, Roman V. Agafonov, Arushi Jain, Graham P. Marsh, Prasoon Chaturvedi, Hannah J. Maple, Scott J. Eron, Emily S. Kibbler
Publikováno v:
Current Research in Chemical Biology, Vol 1, Iss, Pp 100010-(2021)
In addition to the therapeutic applicability of targeted protein degradation (TPD), the modality also harbors unique properties that enable the development of innovative chemical biology tools to interrogate complex biology. TPD offers an all-chemica