Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Eunice Paisana"'
Autor:
Lena Blümel, Nan Qin, Johannes Berlandi, Eunice Paisana, Rita Cascão, Carlos Custódia, David Pauck, Daniel Picard, Maike Langini, Kai Stühler, Frauke-Dorothee Meyer, Sarah Göbbels, Bastian Malzkorn, Max C. Liebau, João T. Barata, Astrid Jeibmann, Kornelius Kerl, Serap Erkek, Marcel Kool, Stefan M. Pfister, Pascal D. Johann, Michael C. Frühwald, Arndt Borkhardt, Guido Reifenberger, Claudia C. Faria, Ute Fischer, Martin Hasselblatt, Jasmin Bartl, Marc Remke
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-13 (2022)
Abstract Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant brain tumor in infants that is characterized by loss of nuclear expression of SMARCB1 or SMARCA4 proteins. Recent studies show that AT/RTs comprise three molecular subgroups, nam
Externí odkaz:
https://doaj.org/article/135ad632b2b8459392b5b46750bd8481
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15792 (2023)
Glioblastoma (GB) and brain metastases (BM) are the most common brain tumors in adults and are invariably associated with a dismal outcome. These highly malignant tumors share common features including increased invasion and migration of the primary
Externí odkaz:
https://doaj.org/article/faf15a97bd024a3f9a30964a56ae97f4
Autor:
Rita Cascão, Bruno Vidal, Inês P Lopes, Eunice Paisana, José Rino, Luis F Moita, João E Fonseca
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0142448 (2015)
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30%
Externí odkaz:
https://doaj.org/article/29fd9127b4f44fd2b11c1360f3800704
Autor:
Nan Qin, Eunice Paisana, Maike Langini, Daniel Picard, Bastian Malzkorn, Carlos Custódia, Rita Cascão, Frauke-Dorothee Meyer, Lena Blümel, Sarah Göbbels, Kübra Taban, Jasmin Bartl, Nicole Bechmann, Catleen Conrad, Jan Gravemeyer, Jürgen C Becker, Anja Stefanski, Stéphanie Puget, João T Barata, Kai Stühler, Ute Fischer, Jörg Felsberg, Olivier Ayrault, Guido Reifenberger, Arndt Borkhardt, Graeme Eisenhofer, Claudia C Faria, Marc Remke
Publikováno v:
Neuro Oncol
Background Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy, and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a particular
Autor:
Eunice Paisana, Rita Cascão, Carlos Custódia, Nan Qin, Daniel Picard, David Pauck, Tânia Carvalho, Pedro Ruivo, Rafael Roque, José Pimentel, Marc Remke, João T Barata, Cláudia C Faria
Publikováno v:
Neuro-Oncology Advances. 4:i1-i2
Brain metastases (BMs) are a devastating complication of advanced cancers associated with poor prognosis. Contrarily to the current improvement in systemic therapies, BMs are still incurable and one of the main causes of death in cancer patients. We
Autor:
Claudia C. Faria, Rita Cascão, Carlos Custódia, Eunice Paisana, Tânia Carvalho, Pedro Pereira, Rafael Roque, José Pimentel, José Miguéns, Isidro Cortes-Ciriano, João T. Barata
Publikováno v:
Cell reports. Medicine. 3(5)
Dissemination of cancer cells from primary tumors to the brain occurs in many cancer patients, increasing morbidity and death. There is an unmet medical need to develop translational platforms to evaluate therapeutic responses. Toward this goal, we e
Autor:
Carlos Custódia, Eunice Paisana, Rita Cascão, José Miguéns, Claudia C. Faria, Tânia Carvalho, José Pimentel, Rafael Roque, João T. Barata, Pedro M. Pereira
PurposeDissemination of cancer cells from primary tumors to the brain is observed in the great majority of cancer patients, contributing to increased morbidity and being the main cause of death. Most mechanistic and preclinical studies have relied on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852187f52c9237f180d0010cd593dcb9
https://doi.org/10.1101/2020.11.26.400036
https://doi.org/10.1101/2020.11.26.400036
Autor:
Tânia Carvalho, Eunice Paisana, Pedro Pereira, Rita Cascão, Marc Remke, Rafael Roque, David Pauck, Daniel Picard, João T. Barata, Pedro Ruivo, Claudia C. Faria, José Pimentel, Nan Qin, José Miguéns, Carlos Custódia
Publikováno v:
Neuro-oncology Advances
The dissemination of cancer cells to the brain parenchyma (brain metastases - BMs) and to the leptomeninges (leptomeningeal dissemination – LD) are a late-stage complication of systemic cancers, with a poor survival. Despite advances in radiation a
BIOL-02. CELLULAR HETEROGENEITY CONTRIBUTES TO THE AGGRESSIVE BEHAVIOR OF MYC-DRIVEN MEDULLOBLASTOMA
Autor:
Claudia C. Faria, Marc Remke, Anja Stefanski, Frauke Meyer, Kai Stühler, Maike Langini, Nan Qin, Carlos Custódia, Guido Reifenberger, Arndt Borkhardt, Daniel Picard, Eunice Paisana, Rita Cascão
INTRODUCTION: Medulloblastoma is the most common malignant brain tumor of childhood and is a genetically heterogeneous disease. Amongst all medulloblastoma subgroups, MYC-amplified medulloblastomas are associated with a particularly poor prognosis as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac34d50d9e1bff72780e4d90f47bb897
https://europepmc.org/articles/PMC6477437/
https://europepmc.org/articles/PMC6477437/
Autor:
Arndt Borkhardt, Thomas Beez, Viktoria Marquardt, Hans Jakob Steiger, Mara Maue, Eunice Paisana, Christian Dimitriadis, Kübra Taban, Lena Blümel, Ute Fischer, Claudia C. Faria, Rita Cascão, Guido Reifenberger, Daniel Picard, Marc Remke, Jasmin Bartl, Sevgi Sarikaya-Seiwert, David Pauck
Publikováno v:
Neuro-Oncology
Subgroups of ependymoma, especially RELA fusion-positive and posterior fossa type A tumors, are associated with poor prognosis. Curative therapeutic strategies have not yet been identified. We set up a high-throughput drug screening (HTS) pipeline to