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TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues

Autor: Bryan A. Ballif, Eunice Pae, John Blenis, Rana Anjum

Publikováno v: FEBS Letters. 586:3471-3476

N-alpha-tosyl-l-phenylalanyl chloromethyl ketone (TPCK) has anti-tumorigenic properties, but its direct cellular targets are unknown. Previously, we showed TPCK inhibited the PDKl-dependent AGC kinases RSK, Akt and S6K1 without inhibiting PKA, ERK1/2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b39b7cb7b5bba237a51fa8e7a2fa2987
https://doi.org/10.1016/j.febslet.2012.07.075

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Extensive HLA class I allele promiscuity among viral CTL epitopes

Publikováno v: European Journal of Immunology. 37:2419-2433

Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3976035b4412908691a01c52a263159d
https://doi.org/10.1002/eji.200737365

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Longitudinal Analysis of Clinical Markers following Antiretroviral Therapy Initiated during Acute or Early HIV Type 1 Infection

Autor: Daniel E. Cohen, Nesli Basgoz, Kimon C. Zachary, Paul E. Sax, Bruce D. Walker, Nicole C. Burgett, Ben D. Davis, Sigall Kassutto, Kaveh Maghsoudi, Eric S. Rosenberg, Victor DeGruttola, Eunice Pae, Gregory K. Robbins, Mary N. Johnston, Erika M. C. D'Agata

Publikováno v: Clinical Infectious Diseases. 42:1024-1031

Background. Treatment of acute human immunodeficiency virus type 1 (HIV-1) infection may have unique immunologic, virological, and clinical benefits. However, the timing of treatment, optimal starting regimens, and expected response to therapy have n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5e54374d3a66b9c48b050c67019517
https://doi.org/10.1086/500410

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HIV-1–specific cytotoxicity is preferentially mediated by a subset of CD8+ T cells producing both interferon-γ and tumor necrosis factor–α

Autor: Xu G. Yu, Michael T. Waring, Marylyn M. Addo, Eric S. Rosenberg, Galit Alter, John Zaunders, Danny Cohen, Todd M. Allen, Eunice Pae, Daryld Strick, Bruce D. Walker, Mary N. Johnston, Mathias Lichterfeld, Marcus Altfeld, Stanley K. Mui

Publikováno v: Blood. 104:487-494

CD8+ T cells play a crucial role in the control of viral infections by direct elimination of infected cells and secretion of a number of soluble factors. Recent data suggest that HIV-1-specific CD8+ T cell subsets may differ in their ability to exert

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61085e9a020b28aa339beb34685057b
https://doi.org/10.1182/blood-2003-12-4341

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HIV-1 Nef is preferentially recognized by CD8 T cells in primary HIV-1 infection despite a relatively high degree of genetic diversity

Autor: Bruce D. Walker, Daryld Strick, Todd M. Allen, Mathias Lichterfeld, Marcus Altfeld, Eric S. Rosenberg, Marylyn M. Addo, Beth Perkins, Xu G. Yu, Danny Cohen, Eunice Pae, Bette T. Korber, Jessica Malenfant, Mary N. Johnston

Publikováno v: AIDS. 18:1383-1392

OBJECTIVE To compare the magnitude, breadth and protein specificity of HIV-1-specific CD8 T-cell responses against the clade B consensus sequence during primary and chronic HIV-1 infection and to analyze the impact of viral diversity on the localizat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f62a49fca4eb55196b07d864a25f043
https://doi.org/10.1097/01.aids.0000131329.51633.a3

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Loss of HIV-1–specific CD8+ T Cell Proliferation after Acute HIV-1 Infection and Restoration by Vaccine-induced HIV-1–specific CD4+ T Cells

Autor: Bruce D. Walker, Marylyn M. Addo, Daniel Kaufmann, Alysse G. Wurcel, Eunice Pae, Xu G. Yu, David Stone, Daniel E. Cohen, Galit Alter, Mathias Lichterfeld, Marcus Altfeld, Stanley K. Mui, Gregory K. Robbins, Mary N. Johnston, Eric S. Rosenberg

Publikováno v: The Journal of Experimental Medicine

Virus-specific CD8+ T cells are associated with declining viremia in acute human immunodeficiency virus (HIV)1 infection, but do not correlate with control of viremia in chronic infection, suggesting a progressive functional defect not measured by in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856126d6cf4009c26e2a1108f45bb509
http://europepmc.org/articles/PMC2211961

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Disruption of 3-phosphoinositide-dependent kinase 1 (PDK1) signaling by the anti-tumorigenic and anti-proliferative agent n-alpha-tosyl-l-phenylalanyl chloromethyl ketone

Autor: John Blenis, Bryan A. Ballif, Akiko Shimamura, Eunice Pae

Publikováno v: The Journal of biological chemistry. 276(15)

The anti-tumorigenic and anti-proliferative effects ofN-α-tosyl-l-phenylalanyl chloromethyl ketone (TPCK) have been known for more than three decades. Yet little is known about the discrete cellular targets of TPCK controlling these effects. Previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c63dbb581a80c7eefb30db0bf7cf55
https://pubmed.ncbi.nlm.nih.gov/11278584

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