PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

Autor: Eunice Cho, Hua Jane Lou, Leena Kuruvilla, David A. Calderwood, Benjamin E. Turk

Publikováno v: Cell Reports, Vol 34, Iss 13, Pp 108928- (2021)

Summary: Flux through the RAF-MEK-ERK protein kinase cascade is shaped by phosphatases acting on the core components of the pathway. Despite being an established drug target and a hub for crosstalk regulation, little is known about dephosphorylation

Externí odkaz: https://doaj.org/article/d842ab8e22ec4083aaceb975710eaa28

Socioeconomic status (SES) and 30-day hospital readmissions for chronic obstructive pulmonary (COPD) disease: A population-based cohort study.

Autor: Andrea S Gershon, Deva Thiruchelvam, Shawn Aaron, Matthew Stanbrook, Nicholas Vozoris, Wan C Tan, Eunice Cho, Teresa To

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216741 (2019)

BACKGROUND:Patients with chronic obstructive pulmonary disease (COPD) are more likely to be readmitted than patients with other chronic medical conditions, yet knowledge regarding such readmissions is limited. We aimed to determine factors associated

Externí odkaz: https://doaj.org/article/c98650e236d3459f93cc7c9af859e1ad

The Laugh

Autor: Eunice Cho

Publikováno v: JAMA. 328:1260

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0496abcf4562be5265abeb924e637fc9
https://doi.org/10.1001/jama.2022.12537

Dynamic Profiling of β-Coronavirus 3CL MproProtease Ligand-Binding Sites

Autor: Heng Ma, Syed Tarique Moin, Eunice Cho, Moniza Mujtaba, Arvind Ramanathan, Saman Mehmood, Junqi Yin, Khair Bux, Ruhi Anjum, Mariya Soban, Antonia S. J. S. Mey, Debsindhu Bhowmik, Mohammad Tanweer, Margarida Rosa, Alessandro Pandini, Shozeb Haider, Barira Islam, Sarath Chandra Dantu

Publikováno v: Cho, E, Rosa, M, Anjum, R, Mehmood, S, Soban, M, Mujtaba, M, Bux, K, Moin, S T, Tanweer, M, Dantu, S, Pandini, A, Yin, J, Ma, H, Ramanathan, A, Islam, B, Mey, A S J S, Bhowmik, D & Haider, S 2021, ' Dynamic Profiling of β-Coronavirus 3CL M pro Protease Ligand-Binding Sites ', Journal of Chemical Information and Modeling, vol. 61, no. 6, pp. 3058-3073 . https://doi.org/10.1021/acs.jcim.1c00449
Journal of Chemical Information and Modeling

Data availability statement: The trajectories of Mpro simulations and models of the metastable states can be downloaded from 10.5281/zenodo.4782284. β-coronavirus (CoVs) alone has been responsible for three major global outbreaks in the 21st century

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8bc29d397569298ede49370bb52ad79
https://hdl.handle.net/20.500.11820/a9513bc4-0e66-4fef-9c4e-5f4f0daa976c

Exploring the nexus: Comparing and aligning Planetary Health, One Health, and EcoHealth

Autor: Byomkesh Talukder, Nilanjana Ganguli, Eunice Choi, Mohammadali Tofighi, Gary W. vanloon, James Obrinski

Publikováno v: Global Transitions, Vol 6, Iss , Pp 66-75 (2024)

The interconnectedness between humans and ecosystems highlights the need to protect ecosystems for the well-being of humans and the environment. This has led to the emergence of holistic and interdisciplinary concepts like Planetary Health, One Healt

Externí odkaz: https://doaj.org/article/003cc998610b4d889f7669037491d196