Výsledky vyhledávání - "Eun-young Kwak"

Target-mediated drug disposition modeling of an anti-TFPI antibody (MG1113) in cynomolgus monkeys to predict human pharmacokinetics and pharmacodynamics

Autor: Myung Eun Jung, Jin Hyun Park, Ha Wook Jung, Min Ju Kim, Eun-Young Kwak

Publikováno v: Journal of thrombosis and haemostasis : JTHREFERENCES. 19(6)

Background MG1113 is a human monoclonal antibody of tissue factor pathway inhibitor (TFPI) under development for prophylaxis for hemophilia patients with or without inhibitors against factor VIII products, which have been used for the treatment of he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6836e52d6b52d65ef4caeb30c68e83
https://pubmed.ncbi.nlm.nih.gov/33448093

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203 Preclinical characterization and development of MG1124, a Novel Immune Checkpoint inhibitor targeting CEACAM1 for NSCLC patients

Autor: Jae-Chul Lee, Woo Seok Yang, Hye-Young Park, Hye-mi Nam, Hyun-Jung Cho, Mi-Young Oh, Eun-Young Kwak, Jinhyun Park, Myeng Eun Jung, Hawook Chung, Minju Kim, Jae-Hwan Kim, Byoung Chul Cho

Publikováno v: Regular and young investigator award abstracts.

Background CEACAM1 is the only member of CEACAM family which is expressed on lymphocytes such as T cells and NK cells that mediate suppression of inflammatory T cell response. It is known that CEACAM1-CEACAM1 homophilic interaction induces downregula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23385d699587a8e17e9238c08fdf69b0
https://doi.org/10.1136/jitc-2020-sitc2020.0203

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Preclinical pharmacokinetic characterization of 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl)oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid, a novel DGAT-1 inhibitor

Autor: Ye-Lim Lee, Eun-Young Kwak, Sung-Hoon Ahn, Jin Hee Ahn, Myung Ae Bae, Jaechun Woo, Woon-Ki Cho, Sunjoo Ahn, Jin Sook Song, So Hee Im, Hyewon Seo, Hyun Jung Kwak

Publikováno v: Xenobiotica. 44:465-471

1. A novel diacylglyceride acyltransferase-1 (DGAT-1) inhibitor, 2-(4-(4-(5-(2-phenyl-5-(trifluoromethyl) oxazole-4-carboxamido)-1H-benzo[d]imidazol-2-yl)phenyl)cyclohexyl) acetic acid (KR-69232), was synthesized for a potential therapeutic use again

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09fdadb7e6198275fb04100a3486a84
https://doi.org/10.3109/00498254.2013.847218

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Effects of a Meditation Program on Nurses' Power and Quality of Life

Autor: Sun Ju Chang, Sun-Joo Jang, Se Hee Seo, Da Woon Lee, Eun Young Kwak, Bong-Jin Hahm

Publikováno v: Nursing science quarterly. 29(3)

This study evaluated the effects of meditation programs on nurses’ power and quality of life. In this study, Barrett’s power theory derived from Rogers’ unitary human being science was used as a theoretical framework. A randomized controlled de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a51d1b56e4d29700797eb51d1ea569
https://pubmed.ncbi.nlm.nih.gov/27271136

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Pharmacokinetic characterization of the novel TAZ modulator TM-25659 using a multicompartment kinetic model in rats and a possibility of its drug-drug interactions in humans

Autor: So Hee Im, Woon-Ki Cho, Sung Heum Choi, Yoon-Jee Chae, Nak Jeong Kim, Sung-Hoon Ahn, Myung Ae Bae, Eun-Young Kwak, Byung Hoi Lee, Kyeong-Ryoon Lee, Min-Sun Kim, Jin-Sook Song, Hyewon Seo

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 43(2)

This study evaluated the pharmacokinetics of the novel TAZ modulator TM-25659 in rats following intravenous and oral administration at dose ranges of 0.5-5 mg/kg and 2-10 mg/kg, respectively. Plasma protein binding, plasma stability, liver microsomal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dde634e24eb448998d21c4f811fca1e
https://pubmed.ncbi.nlm.nih.gov/22856387

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