Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Eun-Pyo Hong"'
Autor:
Doo Eun Choi, Jun Wan Shin, Sophia Zeng, Eun Pyo Hong, Jae-Hyun Jang, Jacob M Loupe, Vanessa C Wheeler, Hannah E Stutzman, Ben Kleinstiver, Jong-Min Lee
Publikováno v:
eLife, Vol 12 (2024)
An expanded CAG repeat in the huntingtin gene (HTT) causes Huntington’s disease (HD). Since the length of uninterrupted CAG repeat, not polyglutamine, determines the age-at-onset in HD, base editing strategies to convert CAG to CAA are anticipated
Externí odkaz:
https://doaj.org/article/be3156c656d24edfa4a721019c3ab21e
Autor:
Dong Hyuk Youn, Nayoung Kim, Aran Lee, Sung Woo Han, Jong-Tae Kim, Eun Pyo Hong, Harry Jung, Myeong Seon Jeong, Sung Min Cho, Jin Pyeong Jeon, First Korean Stroke Genetics Association Research (The FirstKSGAR) study
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract We aimed to investigate whether mitochondrial dysfunction in extracellular cerebrospinal fluid (CSF), which is associated with autophagy and mitophagy, might be involved in neurological outcomes in adult patients with hemorrhagic moyamoya di
Externí odkaz:
https://doaj.org/article/b5f2b0e5b86d424b87adf0dc8accdaa3
Autor:
Eun Pyo Hong, Seung Hyuk Lim, Dong Hyuk Youn, Sung Woo Han, Harry Jung, Jae Jun Lee, Jin Pyeong Jeon, on behalf of the First Korean Stroke Genetics Association Research (The FirstKSGAR) Study
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1387 (2024)
Objectives: The occurrence of cognitive deficits after subarachnoid hemorrhage (SAH) is highly possible, leading to vascular dementia. We performed a novel longitudinal genome-wide association study (GWAS) to identify genetic modifications associated
Externí odkaz:
https://doaj.org/article/ce6d9fe7cc714e17ad438fb8eb12ca05
Autor:
Eun Pyo Hong1, Sung Min Cho2, Jong Kook Rhim3, Jeong Jin Park4, Jun Hyong Ahn5, Dong Hyuk Youn1, Jong-Tae Kim1, Chan Hum Park1, Younghyurk Lee1, Jin Pyeong Jeon6 jjs6553@daum.net
Publikováno v:
Journal of Korean Neurosurgical Society. Sep2023, Vol. 66 Issue 5, p525-535. 11p.
Autor:
Eun Pyo Hong1, Dong Hyuk Youn1, Bong Jun Kim1, Jae Jun Lee1, Sehyeon Nam2, Hyojong Yoo2, Heung Cheol Kim3, Jong Kook Rhim4, Jeong Jin Park5, Jin Pyeong Jeon6 jjs6553@daum.net
Publikováno v:
Journal of Korean Neurosurgical Society. Jul2023, Vol. 66 Issue 4, p409-417. 9p.
Autor:
Eun Pyo Hong, Dong Hyuk Youn, Bong Jun Kim, Jun Hyong Ahn, Jeong Jin Park, Jong Kook Rhim, Heung Cheol Kim, Gyojun Hwang, Hong Jun Jeon, Jin Pyeong Jeon
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract In addition to conventional genome-wide association studies (GWAS), a fine-mapping analysis is increasingly used to identify the genetic function of variants associated with disease susceptibilities. Here, we used a fine-mapping approach to
Externí odkaz:
https://doaj.org/article/57d2fff93d49475bb25238b2667f65ee
Allele-specific silencing of the gain-of-function mutation in Huntington’s disease using CRISPR/Cas9
Autor:
Jun Wan Shin, Eun Pyo Hong, Seri S. Park, Doo Eun Choi, Ihn Sik Seong, Madelynn N. Whittaker, Benjamin P. Kleinstiver, Richard Z. Chen, Jong-Min Lee
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Dominant gain-of-function mechanisms in Huntington’s disease (HD) suggest that selective silencing of mutant HTT produces robust therapeutic benefits. Here, capitalizing on exonic protospacer adjacent motif–altering (PAM-altering) SNP (PAS), we d
Externí odkaz:
https://doaj.org/article/8c4d07b7f240401da0278594ea55cf8a
Autor:
Jin Pyeong Jeon, Seonghyeon Kim, Tae Yeon Kim, Sung Woo Han, Seung Hyuk Lim, Dong Hyuk Youn, Bong Jun Kim, Eun Pyo Hong, Chan Hum Park, Jong-Tae Kim, Jun Hyong Ahn, Jong Kook Rhim, Jeong Jin Park, Heung Cheol Kim, Suk Hyung Kang
Publikováno v:
Frontiers in Neurology, Vol 12 (2022)
BackgroundCopeptin has been reported as a predictive biomarker for the prognosis after traumatic brain injury (TBI). However, most of them were in patients with severe TBI and limited value in predicting outcomes in patients with moderate TBI defined
Externí odkaz:
https://doaj.org/article/aa474268a0c743498e1db544027e33dc
Autor:
Kyung-Hee Kim, Eun Pyo Hong, Yukyeong Lee, McLean, Zachariah L., Elezi, Emanuela, Lee, Ramee, Seung Kwak, McAllister, Branduff, Massey, Thomas H., Lobanov, Sergey, Holmans, Peter, Orth, Michael, Ciosi, Marc, Monckton, Darren G., Long, Jeffrey D., Lucente, Diane, Wheeler, Vanessa C., MacDonald, Marcy E., Gusella, James F., Jong-Min Lee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 4/16/2024, Vol. 121 Issue 16, p1-9, 18p
Autor:
Sung Woo Han, Bong Jun Kim, Tae Yeon Kim, Seung Hyuk Lim, Dong Hyuk Youn, Eun Pyo Hong, Jong Kook Rhim, Jeong Jin Park, Jae Jun Lee, Yong Jun Cho, Ben Gaastra, Ian Galea, Jin Pyeong Jeon
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
BackgroundTo assess the association of haptoglobin (Hp) phenotype with neurological and cognitive outcomes in a large cohort of patients with subarachnoid hemorrhage (SAH).MethodsThis prospective multicenter study enrolled patients with aneurysmal SA
Externí odkaz:
https://doaj.org/article/0b52424c01d24a5d9eeae0b5e1d18b5f