Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Eun-Mi Hur"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Neurodegenerative diseases (NDDs) are characterized by the progressive loss of selectively vulnerable populations of neurons, which is responsible for the clinical symptoms. Although degeneration of neurons is a prominent feature that undoubtedly con
Externí odkaz:
https://doaj.org/article/acb0011d669646d29ec155684d92f1cd
Autor:
Ga Ram Jeong, Eun-Hae Jang, Jae Ryul Bae, Soyoung Jun, Ho Chul Kang, Chi-Hu Park, Joo-Ho Shin, Yukio Yamamoto, Keiko Tanaka-Yamamoto, Valina L. Dawson, Ted M. Dawson, Eun-Mi Hur, Byoung Dae Lee
Publikováno v:
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-17 (2018)
Abstract Background Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial and sporadic Parkinson’s disease (PD). Elevated kinase activity is associated with LRRK2 toxicity, but the substrates that mediate neurodege
Externí odkaz:
https://doaj.org/article/82ef80fe0e5944a3bd82d33b19606f98
Autor:
Eun-Mi Hur, Byoung Dae Lee
Publikováno v:
Genes, Vol 12, Iss 4, p 505 (2021)
Parkinson’s disease (PD) is a heterogeneous neurodegenerative disease characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the widespread occurrence of proteinaceous inclusions known as Lewy bodies
Externí odkaz:
https://doaj.org/article/146e07977d5844c1a92e66d5bd7acbfd
Autor:
So Hyun Kim, Sun-Kyoung Im, Soo-Jin Oh, Sohyeon Jeong, Eui-Sung Yoon, C. Justin Lee, Nakwon Choi, Eun-Mi Hur
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Alignment or anisotropic organisation within and between cells enables biological function but is challenging to engineer. Here, the authors align collagen fibres in a pre-strained polydimethylsiloxane mould to generate a 3D scaffold that guides hipp
Externí odkaz:
https://doaj.org/article/e89794de513e40d5b0d47535845a1b69
Autor:
Sang Chul Shin, Sun-Kyoung Im, Eun-Hae Jang, Kyeong Sik Jin, Eun-Mi Hur, Eunice EunKyeong Kim
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1357-1367.e5 (2019)
Summary: Katanin was the first microtubule (MT)-severing enzyme discovered, but how katanin executes MT severing remains poorly understood. Here, we report X-ray crystal structures of the apo and ATPγS-bound states of the catalytic AAA domain of hum
Externí odkaz:
https://doaj.org/article/5edffdc483ac4088863e58112c52ba6a
Autor:
Bo Yoon Lee, Eun-Mi Hur
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1062 (2020)
Oligodendrocytes are specialized cells that myelinate axons in the central nervous system. Defects in oligodendrocyte function and failure to form or maintain myelin sheaths can cause a number of neurological disorders. Oligodendrocytes are different
Externí odkaz:
https://doaj.org/article/c9dab958471d4d6690efd893622cbbe6
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Glycogen synthase kinases 3 (GSK3) α and β are expressed in the nervous system, and disruption of GSK3 signaling has been implicated in a wide range of neurodevelopmental and psychiatric disorders. Although several studies have established a role o
Externí odkaz:
https://doaj.org/article/5c26ebfbc7b24ac4a376464da8206b00
Autor:
Eun-Mi Hur, Byoung Dae Lee
Publikováno v:
International Neurourology Journal, Vol 18, Iss 4, Pp 171-178 (2014)
Microtubules have been among the most successful targets in anticancer therapy and a large number of microtubule-targeting agents (MTAs) are in various stages of clinical development for the treatment of several malignancies. Given that injury and di
Externí odkaz:
https://doaj.org/article/1c4b7ee7bcf84cef8f29d69f57453ddb
Autor:
Jinlong Yin, Gunwoo Park, Tae Hoon Kim, Jun Hee Hong, Youn-Jae Kim, Xiong Jin, Sangjo Kang, Ji-Eun Jung, Jeong-Yub Kim, Hyeongsun Yun, Jeong Eun Lee, Minkyung Kim, Junho Chung, Hyunggee Kim, Ichiro Nakano, Ho-Shin Gwak, Heon Yoo, Byong Chul Yoo, Jong Heon Kim, Eun-Mi Hur, Jeongwu Lee, Seung-Hoon Lee, Myung-Jin Park, Jong Bae Park
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002367 (2016)
[This corrects the article DOI: 10.1371/journal.pbio.1002152.].
Externí odkaz:
https://doaj.org/article/5d8e6f20832a479fa656349dbb071f2d
Publikováno v:
Neural Plasticity, Vol 2016 (2016)
Several studies have demonstrated the therapeutic potential of applying microtubule- (MT-) stabilizing agents (MSAs) that cross the blood-brain barrier to promote axon regeneration and prevent axonal dystrophy in rodent models of spinal cord injury a
Externí odkaz:
https://doaj.org/article/8d556cc2292646e69e90d9dea7e57bde