Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Eun-Kyung Yoo"'
Autor:
Jun Yong Choi, Shin-Yeong Kim, Sun Woo Lee, Hye Lim Choi, Hyang Ji Chae, Eun Kyung Yoo, Chang Won Min, Junghwan Choi, Bo Kyung Sun, Eun Young Kwak, Yongyea Park, Sungjoon Kim, JongRan Kim, Jong Heun Lee, Chan Sun Park
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/36ae997537d7414a8bc1b54b256c21c9
Autor:
Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee, Jung-whan Kim, Yeon-Kyung Choi, Keun-Gyu Park, Ajay Chawla, Jongsoon Lee, Robert A. Harris, In-Kyu Lee
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Metabolic reprogramming during macrophage polarization supports the effector functions of these cells in health and disease. Here, we demonstrate that pyruvate dehydrogenase kinase (PDK), which inhibits the pyruvate dehydrogenase-mediated conversion
Externí odkaz:
https://doaj.org/article/3e6ebf55ddb64a868809df4fe880a698
Autor:
Won Gun Choi, Jin Sook Song, Hail Kim, Dooseop Kim, Jin Hee Ahn, Myung Ae Bae, Wonsuk Choi, Heejong Lee, Minhee Kim, Jae-Han Jeon, Inkyu Lee, Haushabhau S. Pagire, Inseon Hwang, Eun Kyung Yoo, Jihyeon Yoon, Seung Mi Lee, Won Mi Lee, Eun Young Lee, Mi Jin Kim, Suvarna H. Pagire
Publikováno v:
Journal of Medicinal Chemistry. 63:4171-4182
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy h
Autor:
Chul-Ho Lee, Dong Wook Kim, Hyeon-Ji Kang, Jae-Han Jeon, Bo-Yoon Park, Jeong Eun Kim, Hui Eon Kim, Yong-Hoon Kim, Sungmi Park, Chang Joo Oh, Inkyu Lee, Byong-Keol Min, Ji Min Lee, Eun Kyung Yoo, Yong Hyun Jeon, Mi Jin Kim, Younghoon Go
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 10, Pp 1-12 (2019)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Dyslipidemia-induced atherosclerosis, which has a risk of high morbidity and mortality, can be alleviated by metabolic activation associated with mitochondrial function. The effect of dichloroacetate (DCA), a general pyruvate dehydrogenase kinase (PD
Autor:
Sungmi Park, Inkyu Lee, Injae Shin, Nam Doo Kim, Mi Jin Kim, Taebo Sim, Eun Kyung Yoo, Hojong Yoon, Kyungseon Cho, Hanna Cho
Publikováno v:
Journal of Medicinal Chemistry. 62:8461-8479
Pyruvate dehydrogenase kinases (PDHKs) promote abnormal respiration in cancer cells. Studies with novel resorcinol amide derivatives based on VER-246608 (6) led to the identification of 19n and 19t containing five-membered heteroaromatic rings as uni
Autor:
Mahesh Dighe, Jin Hee Ahn, Myung Ae Bae, Haushabhau S. Pagire, Eun Jung Bae, Sungmi Park, Kwan-Young Jung, Hee Eon Gim, Seungmi Lee, Tae-Ho Lee, Suvarna H. Pagire, Kwang-Hyeon Liu, Young In Chi, Ga-Hyun Lee, Kyu Myung Lee, Jin Sook Song, Ashok Kumar Jaladi, Minhee Kim, Yong Hyun Jeon, Jae-Han Jeon, Eun Kyung Yoo, Inkyu Lee, Dahye Lee, Won-Il Choi, Yoon Kyung Jang
Publikováno v:
Journal of Medicinal Chemistry. 62:575-588
Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. Structural modifications of hit anthraquinone led to the identification of a new series of all
Autor:
Jina Kim, Chun Young Im, Eun Kyung Yoo, Min Jung Ma, Sang-Bum Kim, Eunmi Hong, Jungwook Chin, Hayoung Hwang, Sungwoo Lee, Nam Doo Kim, Jae-Han Jeon, In-Kyu Lee, Yong Hyun Jeon, Hueng-Sik Choi, Seong Heon Kim, Sung Jin Cho
Publikováno v:
Molecules, Vol 21, Iss 1, p 80 (2016)
GSK5182 (4) is currently one of the lead compounds for the development of estrogen-related receptor gamma (ERRγ) inverse agonists. Here, we report the design, synthesis, pharmacological and in vitro absorption, distribution, metabolism, excretion, t
Externí odkaz:
https://doaj.org/article/51d474224d844cfc9eb9d3b1036ceb23
Autor:
Minhee, Kim, Inseon, Hwang, Haushabhau S, Pagire, Suvarna H, Pagire, Wonsuk, Choi, Won Gun, Choi, Jihyeon, Yoon, Won Mi, Lee, Jin Sook, Song, Eun Kyung, Yoo, Seung Mi, Lee, Mi-Jin, Kim, Myung Ae, Bae, Dooseop, Kim, Heejong, Lee, Eun-Young, Lee, Jae-Han, Jeon, In-Kyu, Lee, Hail, Kim, Jin Hee, Ahn
Publikováno v:
Journal of medicinal chemistry. 63(8)
Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent worldwide, causing serious liver complications, including nonalcoholic steatohepatitis. Recent findings suggest that peripheral serotonin (5-hydroxytryptamine, 5HT) regulates energy h
Autor:
Jae-Han Jeon, Inkyu Lee, Yong Hyun Jeon, Jeong Eun Kim, Woong Kwon, Younghoon Go, Nam Ho Jeoung, Ling He, Hye Jin Ham, Bo Yoon Park, Byung-Gyu Kim, Eun Kyung Yoo, Keun-Gyu Park, Robert A. Harris, Seung Hoi Koo
Publikováno v:
Diabetes. 67:2054-2068
In fasting or diabetes, gluconeogenic genes are transcriptionally activated by glucagon stimulation of the cAMP-protein kinase A (PKA)–CREB signaling pathway. Previous work showed pyruvate dehydrogenase kinase (PDK) inhibition in skeletal muscle in
Autor:
Inkyu Lee, Sung Jin Cho, Hueng-Sik Choi, Kyung-Hee Kim, Shinae Kim, Thoudam Debraj Singh, Heeseok Yoon, Hee-Jong Hwang, Yong Hyun Jeon, Seo Yeon Woo, Chun Young Im, Hayoung Hwang, Kim Hyoji, Jina Kim, Jae-Han Jeon, Eun Kyung Yoo, Sang-Wook Kim, Seong Heon Kim, Jungwook Chin, Oh-Bin Kwon, Sung Yeoun Hwang, Cho Joong-Heui, Seungmi Lee, Wonseok Lee
Publikováno v:
Journal of Medicinal Chemistry. 59:10209-10227
We evaluated the in vitro pharmacology as well as the absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties of chemical entities that not only were shown to be highly selective agonists for ERRγ but also exhibited enhanced