Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Eun-Hae Cho"'
Autor:
Minjung Kim, Juntae Park, Seonghee Oh, Byeong-Ho Jeong, Yuree Byun, Sun Hye Shin, Yunjoo Im, Jong Ho Cho, Eun-Hae Cho
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Detecting aberrant cell-free DNA (cfDNA) methylation is a promising strategy for lung cancer diagnosis. In this study, our aim is to identify methylation markers to distinguish patients with lung cancer from healthy individuals. Additionally
Externí odkaz:
https://doaj.org/article/f4baed5d1ad8448b9174eda87a12c4c1
Autor:
Mingyun Bae, Gyuhee Kim, Tae-Rim Lee, Jin Mo Ahn, Hyunwook Park, Sook Ryun Park, Ki Byung Song, Eunsung Jun, Dongryul Oh, Jeong-Won Lee, Young Sik Park, Ki-Won Song, Jeong-Sik Byeon, Bo Hyun Kim, Joo Hyuk Sohn, Min Hwan Kim, Gun Min Kim, Eui Kyu Chie, Hyun-Cheol Kang, Sun-Young Kong, Sang Myung Woo, Jeong Eon Lee, Jai Min Ryu, Junnam Lee, Dasom Kim, Chang-Seok Ki, Eun-Hae Cho, Jung Kyoon Choi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Multi-cancer early detection remains a key challenge in cell-free DNA (cfDNA)-based liquid biopsy. Here, we perform cfDNA whole-genome sequencing to generate two test datasets covering 2125 patient samples of 9 cancer types and 1241 normal c
Externí odkaz:
https://doaj.org/article/df10ed343d5c4d9d913691c7935c3617
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
With advances in next-generation sequencing technology, non-invasive prenatal testing (NIPT) has been widely implemented to detect fetal aneuploidies, including trisomy 21, 18, and 13 (T21, T18, and T13). Most NIPT methods use cell-free DNA (cfDNA) f
Externí odkaz:
https://doaj.org/article/510ecafb3bb64e9292024d86c2119183
Autor:
Serim Kim, Jong Do Seo, Yeo-Min Yun, Hanah Kim, Tae-Eun Kim, Taeheon Lee, Tae-Rim Lee, Jun Hyung Lee, Eun-Hae Cho, Chang-Seok Ki
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Statins are the most popular agents for the primary and secondary prevention of cardiovascular disease; however, the pharmacokinetic parameters and associated genetic factors in the Korean population have not been fully elucidated. This s
Externí odkaz:
https://doaj.org/article/ad9caa664c154841b9ca64febf0eb360
Autor:
Seong Eun Bak, Hanwool Kim, Jung Yoon Ho, Eun-Hae Cho, Junnam Lee, Sung Min Youn, Seong-Woo Park, Mi-Ryung Han, Soo Young Hur, Sung Jong Lee, Youn Jin Choi
Publikováno v:
Cancers, Vol 15, Iss 2, p 530 (2023)
Despite the progress in diagnostics and therapeutics, epithelial ovarian cancer (EOC) remains a fatal disease. Using shallow whole-genome sequencing of plasma cell-free DNA (cfDNA), we investigated biomarkers that could detect EOC and predict surviva
Externí odkaz:
https://doaj.org/article/75eb11ed337146ff88d46b248ade3cfa
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Background Combined methylmalonic acidemia and homocystinuria is a rare inherited disorder of intracellular cobalamin metabolism caused by biallelic variants in one of the following genes: MMACHC (cblC), MMADHC (cblD), LMBRD1 (cblF), ABCD4 (
Externí odkaz:
https://doaj.org/article/b07b422cf45743238f53c5b6c376b936
Autor:
Chung Ryul Oh, Sun-Young Kong, Hyeon-Su Im, Hwa Jung Kim, Min Kyeong Kim, Kyong-Ah Yoon, Eun-Hae Cho, Ja-Hyun Jang, Junnam Lee, Jihoon Kang, Sook Ryun Park, Baek-Yeol Ryoo
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-13 (2019)
Abstract Background Although sorafenib is the global standard first-line systemic treatment for unresectable hepatocellular carcinoma (HCC), it does not have reliable predictive or prognostic biomarkers. Circulating cell-free DNA (cfDNA) has shown pr
Externí odkaz:
https://doaj.org/article/d4b0634ea94245ef911858c5c705d2ab
Autor:
Sang Myung Woo, Min Kyeong Kim, Boram Park, Eun-Hae Cho, Tae-Rim Lee, Chang-Seok Ki, Kyong-Ah Yoon, Yun-Hee Kim, Wonyoung Choi, Do Yei Kim, Jin-Hyeok Hwang, Jae Hee Cho, Sung-Sik Han, Woo Jin Lee, Sang-Jae Park, Sun-Young Kong
Publikováno v:
Cancers, Vol 13, Iss 21, p 5466 (2021)
Genomic instability of circulating tumor DNA (ctDNA) as a prognostic biomarker has not been evaluated in pancreatic cancer. We investigated the role of the genomic instability index of ctDNA in pancreatic ductal adenocarcinoma (PDAC). We prospectivel
Externí odkaz:
https://doaj.org/article/bf9fbe86bba14691a2b17839372df15f
Autor:
Kyung-Sun Park, Woochang Lee, Moon-Woo Seong, Sun-Young Kong, Kyung-A Lee, Jung-Sook Ha, Eun-Hae Cho, Sung-Hee Han, Inho Park, Jong-Won Kim
Publikováno v:
Cancers, Vol 13, Iss 9, p 2192 (2021)
In this study, we performed a comprehensive analysis of BRCA1/2 variants and associated cancer risk in Korean patients considering two aspects: variants of uncertain significance (VUS) and pathogenic or likely pathogenic variants (PLPVs) in BRCA1 and
Externí odkaz:
https://doaj.org/article/422dcb320dd549b0baaf6c934bf02834
Autor:
Won Kyung Cho, Junnam Lee, Sung-Min Youn, Dongryul Oh, Do Hoon Lim, Han Gyul Yoon, Eun-Hae Cho, Jae Myoung Noh
Publikováno v:
Radiation Oncology Journal. 41:32-39
Purpose: This study explored the potential feasibility of cell-free DNA (cfDNA) in monitoring treatment response through the measurement of chromosomal instabilities using I-scores in the context of radiation therapy (RT) for other solid tumors.Mater