Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Eun Mi Hwang"'
Astrocytic autophagy plasticity modulates Aβ clearance and cognitive function in Alzheimer’s disease
Autor:
Suhyun Kim, Heejung Chun, Yunha Kim, Yeyun Kim, Uiyeol Park, Jiyeon Chu, Mridula Bhalla, Seung-Hye Choi, Ali Yousefian-Jazi, Sojung Kim, Seung Jae Hyeon, Seungchan Kim, Yeonseo Kim, Yeon Ha Ju, Seung Eun Lee, Hyunbeom Lee, Kyungeun Lee, Soo-Jin Oh, Eun Mi Hwang, Junghee Lee, C. Justin Lee, Hoon Ryu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Astrocytes, one of the most resilient cells in the brain, transform into reactive astrocytes in response to toxic proteins such as amyloid beta (Aβ) in Alzheimer’s disease (AD). However, reactive astrocyte-mediated non-cell aut
Externí odkaz:
https://doaj.org/article/10d1c6d648c04589a8cf3caf530fc135
Autor:
Anup Bhusal, Jae-Hong Kim, Seung-Chan Kim, Eun Mi Hwang, Hoon Ryu, Md. Sekendar Ali, Seung-Chun Park, Won-Ha Lee, Kyoungho Suk
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113813- (2024)
Summary: Peptidoglycan recognition protein 1 (PGLYRP1) is a pattern-recognition protein that mediates antibacterial actions and innate immune responses. Its expression and role in neuroinflammatory conditions remain unclear. We observed the upregulat
Externí odkaz:
https://doaj.org/article/77f0b69a857743ef8a5ae0810ddf5ed5
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S591- (2023)
Externí odkaz:
https://doaj.org/article/df8a6426e5b9475696090fe6c56d99c6
Autor:
Elliot H. Lee, Jung-eun Park, Lizaveta Gotina, Young-Eun Han, Ambily Nath Indu Viswanath, Seonguk Yoo, Bongjin Moon, Jin-Young Hwang, Woo Kyu Park, Yoonjeong Cho, Chiman Song, Sun-Joon Min, Eun Mi Hwang, Hyunbeom Lee, Ae Nim Pae, Eun Joo Roh, Soo-Jin Oh
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115139- (2023)
TREK-1 (TWIK-related potassium channel-1) is a subunit of the two-pore domain potassium (K2p) channel and is widely expressed in the brain. TREK-1 knockout mice were shown to have antidepressant-like effects, providing evidence for the channel's pote
Externí odkaz:
https://doaj.org/article/e75576798c434684a9173742b6f0fcf7
Publikováno v:
Molecular Brain, Vol 16, Iss 1, Pp 1-18 (2023)
Abstract The 14-3-3 protein family with seven isoforms found in mammals is widely expressed in the brain and plays various roles in cellular processes. Several studies have reported that 14-3-3γ, one of the 14-3-3 protein isoforms, is associated wit
Externí odkaz:
https://doaj.org/article/8dd6f0e19f084685bf1366afb83c43ba
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Astrocytes play an important role in increasing synaptic plasticity, regulating endogenous homeostasis, and contributing to neuroprotection but become overactivated or apoptotic in persistent neuroinflammatory responses or pathological conditions. Al
Externí odkaz:
https://doaj.org/article/f8b6e7c11d524b86ac9e56582a99c783
Publikováno v:
Cells, Vol 12, Iss 11, p 1500 (2023)
K2P channels, also known as two-pore domain K+ channels, play a crucial role in maintaining the cell membrane potential and contributing to potassium homeostasis due to their leaky nature. The TREK, or tandem of pore domains in a weak inward rectifyi
Externí odkaz:
https://doaj.org/article/83b9a1629ffc44e8be352a2519be41c5
Autor:
Jae-Hong Kim, Osung Kwon, Anup Bhusal, Jiyoun Lee, Eun Mi Hwang, Hoon Ryu, Jae-Yong Park, Kyoungho Suk
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Transgenic mice are a useful tool for exploring various aspects of gene function. A key element of this approach is the targeted overexpression of specific genes in cells or tissues. Herein, we report for the first time, the generation and characteri
Externí odkaz:
https://doaj.org/article/31d17ddda9864379a19e10a5509ad342
Autor:
Seong-Seop Kim, Yeonju Bae, Osung Kwon, Seung-Hae Kwon, Jong Bok Seo, Eun Mi Hwang, Jae-Yong Park
Publikováno v:
Cells, Vol 11, Iss 20, p 3322 (2022)
Mature astrocytes are characterized by a K+ conductance (passive conductance) that changes with a constant slope with voltage, which is involved in K+ homeostasis in the brain. Recently, we reported that the tandem of pore domains in a weak inward re
Externí odkaz:
https://doaj.org/article/e393b3bc26374256b454e0b1a5d3ab42
Autor:
Byeongjun Lee, Gyu-Sang Hong, Sung Hoon Lee, Hyungsup Kim, Ajung Kim, Eun Mi Hwang, Jiyoon Kim, Min Goo Lee, Jin-Young Yang, Mi-Na Kweon, Chung-Ming Tse, Donowitz Mark, Uhtaek Oh
Publikováno v:
Experimental and Molecular Medicine, Vol 51, Iss 8, Pp 1-14 (2019)
Colitis: Intestinal membrane protein implicated in defective fluid secretion An ion channel, a membrane protein allowing ion transport, that controls the flow of chloride is needed for proper secretion of protective fluids in the intestine. Uhtaek Oh
Externí odkaz:
https://doaj.org/article/4e7c30ad99eb4d6397d3b848cfed433e