Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Eun La Kim"'
Publikováno v:
Marine Drugs, Vol 20, Iss 3, p 203 (2022)
Through activity-guided fractionation, a new triterpene (asperflagin, 1) was isolated as a PPAR-γ agonist from the jellyfish-derived fungus Aspergillus flavus. Asperflagin displayed selective and moderate transactivation effects on PPAR-γ in Ac2F r
Externí odkaz:
https://doaj.org/article/2f9485ee2a7847ff902f8ac27540733b
Publikováno v:
Marine Drugs, Vol 19, Iss 8, p 417 (2021)
Peroxisome proliferator-activated receptor (PPAR) expression has been implicated in pathological states such as cancer, inflammation, diabetes, and neurodegeneration. We isolated natural PPAR agonists—eight 2,5-diketopiperazines—from the jellyfis
Externí odkaz:
https://doaj.org/article/0303618d71c54fe78a2c00beb0c666e5
Autor:
Mingzhi Su, Changhao Zhao, Dandan Li, Jiafu Cao, Zhiran Ju, Eun La Kim, Young-Suk Jung, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 18, Iss 9, p 445 (2020)
Microtubules play a crucial role in mitosis and are attractive targets for cancer therapy. Recently, we isolated viriditoxin, a cytotoxic and antibacterial compound, from a marine fungus Paecilomyces variotii. Viriditoxin has been reported to inhibit
Externí odkaz:
https://doaj.org/article/0b6adde330414953b3d3742de1bc70a7
Autor:
Bin Xiao, Mingzhi Su, Eun La Kim, Jongki Hong, Hae Young Chung, Hyung Sik Kim, Jun Yin, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 12, Iss 2, Pp 926-939 (2014)
A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads. The introduction of hydrophilic and hydrophobic groups to the phthalimide skeleton yiel
Externí odkaz:
https://doaj.org/article/79714100cf624a04914f82ece191b0ed
Autor:
Zhiran Ju, Mingzhi Su, Dandan Li, Jongki Hong, Dong-Soon Im, Suhkmann Kim, Eun La Kim, Jee H. Jung
Publikováno v:
Marine Drugs, Vol 17, Iss 6, p 321 (2019)
In our previous study, a synthetic compound, (+)-(R,E)-6a1, that incorporated the key structures of anti-inflammatory algal metabolites and the endogenous peroxisome proliferator-activated receptor γ (PPAR-γ) ligand 15-deoxy-∆12,14-prostaglandin
Externí odkaz:
https://doaj.org/article/91a2a7d97cff48d1b88cf3dcc03139c5
Autor:
Dan-Dan Li, Dong-Hao Bai, Jee H. Jung, Bin Xiao, Ying Wang, Na Zhao, Shang-Wu Jin, Li-Dong Sun, Eun La Kim
Publikováno v:
Biomolecules & Therapeutics
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ff812d1598480f51293fff0ab5282e3
http://europepmc.org/articles/PMC8411028
http://europepmc.org/articles/PMC8411028
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 1; Pages: 802
Atractylodin is a major compound in the rhizome of Atractylodeslancea, an oriental herbal medicine used for the treatment of gastrointestinal diseases, including dyspepsia, nausea, and diarrhea. Recent studies have shown that atractylodin exerts anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a537a26ca7b438f274b24c67bc4b9a3
https://doi.org/10.3390/ijms24010802
https://doi.org/10.3390/ijms24010802
Autor:
Suhkmann Kim, Jongki Hong, Eun La Kim, Hae Young Chung, Zhiran Ju, Jee H. Jung, Hyung Ryong Moon, Mingzhi Su
Publikováno v:
European Journal of Medicinal Chemistry. 180:86-98
The aim of this study was to design and synthesize COX-1/COX-2 balanced inhibitors incorporating the structural motifs of anti-inflammatory ascidian metabolites. We designed a series of substituted indole analogs that incorporate the key structures o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88742260efec9629ed145097b313eed9
https://doi.org/10.1016/j.ejmech.2019.07.016
https://doi.org/10.1016/j.ejmech.2019.07.016
Autor:
Jongki Hong, Suhkmann Kim, Zhiran Ju, Eun La Kim, Chang-Hao Zhao, Jee H. Jung, Hyung Ryong Moon, Mingzhi Su, Sultan Ullah
Publikováno v:
European Journal of Medicinal Chemistry. 157:1192-1201
In a previous study, we synthesized endocyclic enone jasmonate derivatives that function as anti-inflammatory and PPAR-γ-activating entities by using key functional moieties of anti-inflammatory algal metabolites. Herein, we designed additional deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c920a6b475dd00df2782b305d6c4952a
https://doi.org/10.1016/j.ejmech.2018.08.090
https://doi.org/10.1016/j.ejmech.2018.08.090
Publikováno v:
Bioorganic chemistry. 96
In our previous study, a PPAR-γ agonist (+)-(R,E)-6a1 was elaborated as an anti-inflammatory lead. However, in silico analysis showed that (+)-(R,E)-6a1 lacks key hydrogen bonding with Tyr473 of PPAR-γ LBD (ligand binding domain). To facilitate add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ce1df7207f9feeb21a570e537c6ace
https://pubmed.ncbi.nlm.nih.gov/32007723
https://pubmed.ncbi.nlm.nih.gov/32007723