Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Eun Kyoung Bang"'
A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety
Autor:
Seo-Hyeon Bae, Soyeon Yoo, Jisun Lee, Hyo-Jung Park, Sung Pil Kwon, Harin Jin, Sang-In Park, Yu-Sun Lee, Yoo-Jin Bang, Gahyun Roh, Seonghyun Lee, Sue Bean Youn, In Woo Kim, Ho Rim Oh, Ashraf K. El-Damasy, Gyochang Keum, Hojun Kim, Hyewon Youn, Jae-Hwan Nam, Eun-Kyoung Bang
Publikováno v:
Bioactive Materials, Vol 38, Iss , Pp 486-498 (2024)
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control of the COVID-19 pandemic. However, mRNA vaccines have raised concerns about their potential toxicity and clinical safety, inc
Externí odkaz:
https://doaj.org/article/c48d472deaca44c3aad77211ea466fb1
Autor:
Hyeong-Jun Park, Yoo-Jin Bang, Sung Pil Kwon, Woori Kwak, Sang-In Park, Gahyun Roh, Seo-Hyeon Bae, Jae-Yong Kim, Hye Won Kwak, Yongkwan Kim, Soyeon Yoo, Daegeun Kim, Gyochang Keum, Eun-Kyoung Bang, So-Hee Hong, Jae-Hwan Nam
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have been developed against SARS-CoV-2. This has unintentionally created a unique scenario where
Externí odkaz:
https://doaj.org/article/5c5ff5fcc5a54c4e820b09bd1e7031cd
Autor:
Ashraf K. El-Damasy, Hyun Ji Kim, Jung Woo Park, Yunju Nam, Wooyoung Hur, Eun-Kyoung Bang, Gyochang Keum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
BCR-ABL inhibition is an effective therapeutic approach for the treatment of chronic myeloid leukaemia (CML). Herein, we report the discovery of AKE-72 (5), a diarylamide 3-aminoindazole, as a potent pan-BCR-ABL inhibitor, including the imatinib-resi
Externí odkaz:
https://doaj.org/article/b282f6bb9b90428e8aa1d7677a46c18c
Autor:
Ashraf K. El-Damasy, Heewon Jin, Jung Woo Park, Hyun Ji Kim, Hanan Khojah, Seon Hee Seo, Ju-Hyeon Lee, Eun-Kyoung Bang, Gyochang Keum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
The design of kinase inhibitors targeting the oncogenic kinase BCR-ABL constitutes a promising paradigm for treating chronic myeloid leukaemia (CML). Nevertheless, the efficacy of imatinib, the first FDA-approved targeted therapy for CML, is curbed b
Externí odkaz:
https://doaj.org/article/f79db7a7810b42be86ef54f6e1581a0e
Autor:
Ashraf K. El-Damasy, Hyun Ji Kim, Alessio Nocentini, Seon Hee Seo, Wagdy M. Eldehna, Eun-Kyoung Bang, Claudiu T. Supuran, Gyochang Keum
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
A series of 6-ureido/amidocoumarins (5a–p and 7a–c) has been designed and synthesised to develop potent and isoform- selective carbonic anhydrase hCA XI and XII inhibitors. All coumarin derivatives were investigated for their CA inhibitory effect
Externí odkaz:
https://doaj.org/article/7b6dab7f30fe4aee93cac9edd05477c1
Autor:
Ashraf K. El-Damasy, Hyun Ji Kim, Ahmed A. Al-Karmalawy, Radwan Alnajjar, Mohamed M. Khalifa, Eun-Kyoung Bang, Gyochang Keum
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 427 (2024)
Discoidin domain receptor 1 (DDR1) kinase has emerged as a promising target for cancer therapy, and selective DDR1 inhibitors have shown promise as effective therapeutic candidates. Herein, we have identified the first coumarin-based selective DDR1 i
Externí odkaz:
https://doaj.org/article/0df99d9f11c14b339e86b40d4ee96d20
Autor:
Ashraf K. El-Damasy, Heewon Jin, Mohamed A. Sabry, Hyun Ji Kim, Mohammed M. Alanazi, Seon Hee Seo, Eun-Kyoung Bang, Gyochang Keum
Publikováno v:
Medicina, Vol 59, Iss 6, p 1076 (2023)
A new series of 3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with substituted piperazine showed the best antiproliferative activity. In the
Externí odkaz:
https://doaj.org/article/658d6653256e4f9d8289ff3346737c90
Autor:
Ashraf K. El-Damasy, Jong Eun Park, Hyun Ji Kim, Jinhyuk Lee, Eun-Kyoung Bang, Hoon Kim, Gyochang Keum
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 83 (2023)
Monoamine oxidase-B (MAO-B), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) have been considered target enzymes of depression and neurodegenerative diseases, including Alzheimer’s disease (AD). In this study, seventeen N-methyl-piper
Externí odkaz:
https://doaj.org/article/32a44b2c4bc94d6885f380f1e6a4b63b
Autor:
Keum, Ashraf K. El-Damasy, Heewon Jin, Mohamed A. Sabry, Hyun Ji Kim, Mohammed M. Alanazi, Seon Hee Seo, Eun-Kyoung Bang, Gyochang
Publikováno v:
Medicina; Volume 59; Issue 6; Pages: 1076
A new series of 3,4,5-trimethoxyphenyl thiazole pyrimidines has been synthesized and biologically evaluated for its in vitro anticancer activity. Compounds 4a, 4b, and 4h with substituted piperazine showed the best antiproliferative activity. In the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a39868b90d15f3c5f56aeaca1a826568
Autor:
Rae Hyung Kang, Youngwoong Kim, Hye Ji Um, Jaehoon Kim, Eun-Kyoung Bang, Seung Geun Yeo, Dokyoung Kim
Publikováno v:
ACS Applied Nano Materials. 5:5387-5397
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155f5809e4d3921922acfec5ea800c51
https://doi.org/10.1021/acsanm.2c00368
https://doi.org/10.1021/acsanm.2c00368