Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eun Hee Yi"'
Autor:
Sang-kyu Ye, Ik-Hyun Cho, Yong-Nyun Kim, Dong-Young Noh, Wonshik Han, Jung Weon Lee, Keon Wook Kang, Chung-Hyun Cho, Min Kyung Shin, Young Ju Lee, Jin-Ku Lee, Chang Seok Lee, Eun Hee Yi
The acquisition of tamoxifen resistance is a major therapeutic problem in breast cancer. We developed a tamoxifen-resistant MCF-7 (TRM-7) cell line to elucidate the molecular mechanisms and factors associated with acquisition of such resistance. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e06900b4bc72230ee09f084065ea9d
https://doi.org/10.1158/1541-7786.c.6541545
https://doi.org/10.1158/1541-7786.c.6541545
Autor:
Jens Luebeck, Sandeep Namburi, Paul S. Mischel, Roel G.W. Verhaak, Howard Y. Chang, Hoon Kim, Kristen M. Turner, Samirkumar B. Amin, Vineet Bafna, Eun Hee Yi, Sihan Wu, Johannes H. Schulte, Nam-Phuong Nguyen, Utkrisht Rajkumar, Francesca Menghi, Anton G. Henssen, Viraj Deshpande, Christine R. Beck, Amit D. Gujar, Jihe Liu
Publikováno v:
Nature genetics
Kim, H, Nguyen, N-P, Turner, K, Wu, S, Gujar, A D, Luebeck, J, Liu, J, Deshpande, V, Rajkumar, U, Namburi, S, Amin, S B, Yi, E, Menghi, F, Schulte, J H, Henssen, A G, Chang, H Y, Beck, C R, Mischel, P S, Bafna, V & Verhaak, R G W 2020, ' Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers ', Nature Genetics, vol. 52, no. 9, pp. 891-897 . https://doi.org/10.1038/s41588-020-0678-2
Nature Genetics, 52(9), 891-897. Nature Publishing Group
Kim, H, Nguyen, N-P, Turner, K, Wu, S, Gujar, A D, Luebeck, J, Liu, J, Deshpande, V, Rajkumar, U, Namburi, S, Amin, S B, Yi, E, Menghi, F, Schulte, J H, Henssen, A G, Chang, H Y, Beck, C R, Mischel, P S, Bafna, V & Verhaak, R G W 2020, ' Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers ', Nature Genetics, vol. 52, no. 9, pp. 891-897 . https://doi.org/10.1038/s41588-020-0678-2
Nature Genetics, 52(9), 891-897. Nature Publishing Group
Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity and accelerated tumor evolution1–3, but its frequency and clinical impact are unclear. Here we show, using computational analysis of whole-genome sequencing data
Autor:
Amit D. Gujar, Nathaniel Jillette, Hoon Kim, Molly Guthrie, Kevin C. Johnson, Sunit Das, Roel G.W. Verhaak, Dacheng Zhao, Samirkumar B. Amin, Eun Hee Yi, Albert W. Cheng, Qianru Yu, Megan L Costa, Patricia A. Clow
Publikováno v:
Cancer Discov
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models
Autor:
Rahul Maurya, Hoon Kim, Sunit Das, Amit D. Gujar, Philip C. De Witt Hamer, Elise T. Courtois, Chew Yee Ngan, Kevin J. Anderson, Floris P. Barthel, Niels Verburg, Kevin C. Johnson, Dacheng Zhao, Ketan R. Bulsara, Martine Seignon, Paul Robson, Frederick S. Varn, Eun Hee Yi, Nicholas Navin, Marcos R. Estecio, Diane Luo, Roel G.W. Verhaak, Michael Samuels, Ming Tang
Publikováno v:
Johnson, K C, Anderson, K J, Courtois, E T, Gujar, A D, Barthel, F P, Varn, F S, Luo, D, Seignon, M, Yi, E, Kim, H, Estecio, M R H, Zhao, D, Tang, M, Navin, N E, Maurya, R, Ngan, C Y, Verburg, N, de Witt Hamer, P C, Bulsara, K, Samuels, M L, Das, S, Robson, P & Verhaak, R G W 2021, ' Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response ', Nature Genetics, vol. 53, no. 10, pp. 1456-1468 . https://doi.org/10.1038/s41588-021-00926-8
Nature Genetics, 53(10), 1456-1468. Nature Publishing Group
Nature Genetics, 53(10), 1456-1468. Nature Publishing Group
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to therapeutic resistance. We integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes and bulk multi-omic profiles across 11 ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad1ae7e79d3ae7c7008a19eba37ea4d
https://research.vumc.nl/en/publications/3ef3cb20-34eb-4d85-9b84-b617090e15d1
https://research.vumc.nl/en/publications/3ef3cb20-34eb-4d85-9b84-b617090e15d1
Autor:
In Hye Lee, Jongsun Park, Jaegal Shim, Eun Hee Yi, Sang Kyu Ye, Ji Hye Lee, Yong Nyun Kim, Jae Seon Lee, Sung-Ho Goh, Un Jung Yun, Kyungsil Yoon, Hyunji Lee
Publikováno v:
Laboratory Investigation. 99:1157-1172
Doxorubicin is a widely used DNA damage-inducing anti-cancer drug. However, its use is limited by its dose-dependent side effects, such as cardiac toxicity. Cholesterol-lowering statin drugs increase the efficacy of some anti-cancer drugs. Cholestero
Publikováno v:
Journal of Breast Cancer
Purpose The chemical structure of tubulosine has been known since the mid-1960s. However, little is known about its biological and pharmacological functions. The aim of this study was to investigate the novel functions of tubulosine in cancer treatme
Autor:
Amit D. Gujar, Patricia A. Clow, Samirkumar B. Amin, Albert W. Cheng, Eun Hee Yi, Molly Guthrie, Kevin C. Johnson, Sunit Das, Hoon Kim, Roel G.W. Verhaak
Oncogenic extrachromosomal DNA elements (ecDNAs) promote intratumoral heterogeneity, creating a barrier for successful cancer treatments. The underlying mechanisms are poorly understood and studies are hampered in part by a lack of adequate tools ena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::927b5e26eea403445e0cd48eb3802f01
https://doi.org/10.1101/2020.10.20.335216
https://doi.org/10.1101/2020.10.20.335216
Autor:
Marcos Rh Estecio, Sunit Das, Eun Hee Yi, Ming Tang, Diane Luo, Elise T. Courtois, Rahul Maurya, Philip C. De Witt Hamer, Frederick S. Varn, Roel G.W. Verhaak, Michael Samuels, Hoon Kim, Chew Yee Ngan, Nicholas Navin, Floris P. Barthel, Kevin C. Johnson, Kevin J. Anderson, Niels Verburg, Ketan R. Bulsara, Martine Seignon, Paul Robson
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to universal therapeutic resistance. Here, we integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes, and bulk multi-omic prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a09885068a8e10c234bfa448228705b4
https://doi.org/10.1101/2020.07.22.215335
https://doi.org/10.1101/2020.07.22.215335
Autor:
Nathaniel Jillette, Kevin M. Johnson, Sunit Das, Amit D. Gujar, Dacheng Zhao, Albert W. Cheng, Roel G.W. Verhaak, Samirkumar B. Amin, Eun Hee Yi, Patricia A. Clow, Hoon Kim, Molly Guthrie
Publikováno v:
Neuro-Oncology. 23:vi20-vi20
Oncogenic extrachromosomal DNA elements (ecDNAs) promote intratumoral heterogeneity, creating a barrier for successful cancer treatments. The underlying mechanisms are poorly understood and studies are hampered in part by a lack of adequate tools ena
Autor:
Frederick S. Varn, Ming Tang, Hoon Kim, Floris P. Barthel, Paul Robson, Michael L. Samuels, Elise T. Courtois, Nicholas Navin, Kevin C. Johnson, Philip C. De Witt Hamer, Kevin J. Anderson, Niels Verburg, Amit D. Gujar, Marcos R. Estecio, Diane Luo, Ketan R. Bulsara, Roel G.W. Verhaak, Eun Hee Yi, Martine Seignon, Rahul Maurya, Chew Yee Ngan, Sunit Das
Publikováno v:
Cancer Research. 81:2084-2084
Glioma intratumoral heterogeneity enables adaptation to challenging microenvironments and contributes to universal therapeutic resistance. Here, we integrated 914 single-cell DNA methylomes, 55,284 single-cell transcriptomes, and bulk multi-omic prof