Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Eulàlia de Nadal"'
Autor:
Maximilian Mosbacher, Sung Sik Lee, Gilad Yaakov, Mariona Nadal-Ribelles, Eulàlia de Nadal, Frank van Drogen, Francesc Posas, Matthias Peter, Manfred Claassen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Cellular decision making often builds on ultrasensitive MAPK pathways. The phosphorylation mechanism of MAP kinase has so far been described as either distributive or processive, with distributive mechanisms generating ultrasensitivity in th
Externí odkaz:
https://doaj.org/article/0960943550834387b65d093a11cd7dac
Autor:
Carlos Jiménez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Josep Sánchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura
Publikováno v:
Molecular Cancer, Vol 21, Iss 1, Pp 1-17 (2022)
Abstract Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development. In neuroblastoma, neural crest progenitors blo
Externí odkaz:
https://doaj.org/article/eccd23a922d54a24b80304022f4ce153
Autor:
Delphine Aymoz, Carme Solé, Jean‐Jerrold Pierre, Marta Schmitt, Eulàlia de Nadal, Francesc Posas, Serge Pelet
Publikováno v:
Molecular Systems Biology, Vol 14, Iss 4, Pp 1-13 (2018)
Abstract During development, morphogens provide extracellular cues allowing cells to select a specific fate by inducing complex transcriptional programs. The mating pathway in budding yeast offers simplified settings to understand this process. Phero
Externí odkaz:
https://doaj.org/article/9f1fddb44a8e442ea20d730e29350fe9
Autor:
Alba Duch, Berta Canal, Sonia I. Barroso, María García-Rubio, Gerhard Seisenbacher, Andrés Aguilera, Eulàlia de Nadal, Francesc Posas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
During S phase of the cell cycle, transcription and replication need to be coordinated in order to avoid conflicts leading to potential genomic instability. Here, the authors find that Mrc1 integrates signals from different kinases to regulate replic
Externí odkaz:
https://doaj.org/article/890cd55d01074eb4acae28ff6220fd5b
Autor:
Mariona Nadal-Ribelles, Saiful Islam, Wu Wei, Pablo Latorre, Michelle Nguyen, Eulàlia de Nadal, Francesc Posas, Lars Steinmetz
Publikováno v:
Bio-Protocol, Vol 9, Iss 17 (2019)
Single-cell RNA-seq (scRNA-seq) has become an established method for uncovering the intrinsic complexity within populations. Even within seemingly homogenous populations of isogenic yeast cells, there is a high degree of heterogeneity that originates
Externí odkaz:
https://doaj.org/article/b9980906e8e841aeabc8c51ccb5e49bd
Autor:
Caterina Carbonell, Arnau Ulsamer, Claudia Vivori, Panagiotis Papasaikas, René Böttcher, Manel Joaquin, Belén Miñana, Juan Ramón Tejedor, Eulàlia de Nadal, Juan Valcárcel, Francesc Posas
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 847-859.e6 (2019)
Summary: Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated protein kinases (SAPKs) play a key role in controlling several steps of mRNA biogenesis
Externí odkaz:
https://doaj.org/article/5dfaeded468d4a8b804ed456aaf75a13
Autor:
Antonia M. Romero, Mar Martínez-Pastor, Gang Du, Carme Solé, María Carlos, Sandra V. Vergara, Nerea Sanvisens, James A. Wohlschlegel, David P. Toczyski, Francesc Posas, Eulàlia de Nadal, María T. Martínez-Pastor, Dennis J. Thiele, Sergi Puig
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Iron is an indispensable micronutrient for all eukaryotic organisms due to its participation as a redox cofactor in many metabolic pathways. Iron imbalance leads to the most frequent human nutritional deficiency in the world. Adaptation to i
Externí odkaz:
https://doaj.org/article/21975898f8104989b0a38d1dcc665e65
Publikováno v:
Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)
Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves
Externí odkaz:
https://doaj.org/article/5a5ef5e6fc8741c19dacb92a0a7fb359
Autor:
Andrea Silva, Santiago Cavero, Victoria Begley, Carme Solé, René Böttcher, Sebastián Chávez, Francesc Posas, Eulàlia de Nadal
Publikováno v:
PLoS Genetics, Vol 13, Iss 11, p e1007090 (2017)
Cells trigger massive changes in gene expression upon environmental fluctuations. The Hog1 stress-activated protein kinase (SAPK) is an important regulator of the transcriptional activation program that maximizes cell fitness when yeast cells are exp
Externí odkaz:
https://doaj.org/article/409d03dde98c43eb991f9e9f84361037
Publikováno v:
Molecular & Cellular Oncology, Vol 4, Iss 1 (2017)
The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and del
Externí odkaz:
https://doaj.org/article/7bc0a143557741a49a0664db8f93723c