Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Eugeny A. Lukhtanov"'
Publikováno v:
Nucleic Acids Research. 29:5090-5098
Attachment of oligodeoxynucleotides (ODNs) containing benzaldehyde (BAL) groups to semicarbazide-coated glass (SC-glass) slides is described. 5'-BAL-ODNs are prepared using automated DNA synthesis and an acetal-protected BAL phosphoramidite reagent.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b6a1eac9bb791b75be8055f0fd5f09
https://doi.org/10.1093/nar/29.24.5090
https://doi.org/10.1093/nar/29.24.5090
Publikováno v:
Nucleic Acids Research. 27:2931-2937
Triplex-forming oligonucleotides (TFOs) bind sequence-specifically in the major groove of double-stranded DNA. Cyclopropapyrroloindole (CPI), the electrophilic moiety that comprises the reactive subunit of the antibiotic CC-1065, gives hybridization-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da64a9a17624576412696a2d78cc7f8d
https://doi.org/10.1093/nar/27.14.2931
https://doi.org/10.1093/nar/27.14.2931
Autor:
Eugeny A. Lukhtanov, Daniel Compagno, Jean-Jacques Toulmé, Chantal Bourget, Ludmila Yurchenko, Igor V. Kutyavin, Vladimir V. Gorn, Howard B. Gamper, Jed N. Lampe
Publikováno v:
Journal of Biological Chemistry. 274:8191-8198
Complementary oligodeoxynucleotides (ODNs) that contain 2-aminoadenine and 2-thiothymine interact weakly with each other but form stable hybrids with unmodified complements. These selectively binding complementary (SBC) agents can invade duplex DNA a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d33ff6d92d71b94059e3ce82f12058
https://doi.org/10.1074/jbc.274.12.8191
https://doi.org/10.1074/jbc.274.12.8191
Autor:
Michael W. Reed, and Ansel Wald, Eugeny A. Lukhtanov, Alexander A. Gall, Vladimir V. Gorn, Igor V. Kutyavin, Rich B. Meyer
Publikováno v:
Bioconjugate Chemistry. 9:64-71
A versatile method is described for preparing aryl nitrogen mustard-oligodeoxyribonucleotide (mustard-ODN) conjugates under anhydrous conditions. The chemistry uses DMSO soluble triethylammonium or tributylammonium salts of the ODNs. A G/A motif trip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97e74a05046eb72526bb14db7ec125e
https://doi.org/10.1021/bc970134a
https://doi.org/10.1021/bc970134a
Autor:
and Deborah D. Lucas, Rich B. Meyer, Igor V. Kutyavin, Michael W. Reed, Eugeny A. Lukhtanov, A. David Adams, Vladimir V. Gorn
Publikováno v:
Journal of the American Chemical Society. 119:6214-6225
Oligodeoxyribonucleotides (ODNs) with conjugated reactive groups are potential sequence-specific gene inactivating agents. The antitumor antibiotic CC-1065 binds preferably in the minor groove of A-T-rich sites of double-stranded DNA, and the cyclopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23cf180f1b43451b3b07e57fd5cca9d
https://doi.org/10.1021/ja9703133
https://doi.org/10.1021/ja9703133
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 32(8)
Several 7-(hydroxy, amino, methylureido, and guanidino)alkynyl-substituted 8-aza-7-deaza- hypoxanthine analogues were investigated as potential universal nucleobases. 7-Aminobutynyl-8-aza-7-deazahypoxanthine was found to be the most promising quasi-u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f3ad0b1cd05457770c427a57ac513ee
https://pubmed.ncbi.nlm.nih.gov/23895353
https://pubmed.ncbi.nlm.nih.gov/23895353
Autor:
Howard Gamper, Eugeny A. Lukhtanov, Igor V. Kutyavin, Vladimir V. Gorn, Rebecca L. Rhinehart, Rich B. Meyer
Publikováno v:
Biochemistry. 35:11170-11176
A pair of complementary oligodeoxynucleotides (ODNs) uniformly substituted with 2-amino-adenine (A') in place of adenine and 2-thiothymine (T') in place of thymine did not hybridize to each other but did form very stable hybrids with unmodified compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a86aa3c90dc6d0c79b7653b1bfd0f50
https://doi.org/10.1021/bi960626v
https://doi.org/10.1021/bi960626v
Autor:
Eugeny A. Lukhtanov, Yung-Chi Cheng, Michael W. Reed, Deborah D. Lucas, James H. Zhou, Vladimir V. Gorn, Rich B. Meyer, S. Balakrishna Pai
Publikováno v:
Journal of Medicinal Chemistry. 38:4587-4596
Short DNA duplexes with cholesterol linked at the 3'-terminus of each strand have unique, selective cytotoxic properties. The structural requirements for biological activity were explored through chemical synthesis of analogs and testing in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7184290fa572c1ebaf0a5a424f04b6
https://doi.org/10.1021/jm00022a025
https://doi.org/10.1021/jm00022a025
Publikováno v:
Bioconjugate Chemistry. 6:418-426
Synthesis of a new class of conjugates between oligodeoxyribonucleotides (ODNs) and minor groove binders (MGBs) is described. The MGBs are analogs of the potent antibiotic CC-1065 and consist of repeating 1,2-dihydro-3H-pyrrolo[3,2-e]indole-7-carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7bc17a2ce7dc07f886cb13df94bef4
https://doi.org/10.1021/bc00034a012
https://doi.org/10.1021/bc00034a012
Autor:
Eugeny A. Lukhtanov, Alexei Vorobiev
Publikováno v:
ChemInform. 39
Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9dcfb339d1d02916fe9008359db0e23
https://doi.org/10.1002/chin.200830180
https://doi.org/10.1002/chin.200830180