Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Eugeny A Elisaphenko"'
Autor:
Konstantin E Orishchenko, Sophia V Pavlova, Eugeny A Elisaphenko, Vladimir V Sherstyuk, Alexander V Prinz, Alexander I Shevchenko, Elena V Dementyeva, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33994 (2012)
X chromosome inactivation takes place in the early development of female mammals and depends on the Xist gene expression. The mechanisms of Xist expression regulation have not been well understood so far. In this work, we compared Xist promoter regio
Externí odkaz:
https://doaj.org/article/eadfe504a8364ec38189762fb1907308
Autor:
Alexander I Shevchenko, Anastasia A Malakhova, Eugeny A Elisaphenko, Nina A Mazurok, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22771 (2011)
One of the two X chromosomes in female mammalian cells is subject to inactivation (XCI) initiated by the Xist gene. In this study, we examined in rodents (voles and rat) the conservation of the microsatellite region DXPas34, the Tsix gene (antisense
Externí odkaz:
https://doaj.org/article/be1696b8bc604ade82841535688d6a19
Autor:
Elena V Grigor'eva, Alexander I Shevchenko, Nina A Mazurok, Eugeny A Elisaphenko, Antonina I Zhelezova, Alexander G Shilov, Pavel A Dyban, Andrey P Dyban, Ekaterina M Noniashvili, Sergey Ya Slobodyanyuk, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7161 (2009)
The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors respo
Externí odkaz:
https://doaj.org/article/1ac93b650cf44cbca3927376a27ed73e
Autor:
Eugeny A Elisaphenko, Nikolay N Kolesnikov, Alexander I Shevchenko, Igor B Rogozin, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2521 (2008)
X-chromosome inactivation, which occurs in female eutherian mammals is controlled by a complex X-linked locus termed the X-inactivation center (XIC). Previously it was proposed that genes of the XIC evolved, at least in part, as a result of pseudogen
Externí odkaz:
https://doaj.org/article/2a5d03587e944e00b91b0c1f9f5f481f
Autor:
Maria S. Nazarenko, Aleksei A. Sleptcov, Aleksei A. Zarubin, Ramil R. Salakhov, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Nina V. Zheltysheva, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian, Irina S. Zakharova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4471 (2023)
The LDLR locus has clinical significance for lipid metabolism, Mendelian familial hypercholesterolemia (FH), and common lipid metabolism-related diseases (coronary artery disease and Alzheimer’s disease), but its intronic and structural variants ar
Externí odkaz:
https://doaj.org/article/76a44709a6c6408fb24208c4eaacb4dc
Autor:
Tatyana V. Karamysheva, Tatyana A. Gayner, Eugeny A. Elisaphenko, Vladimir A. Trifonov, Elvira G. Zakirova, Konstantin E. Orishchenko, Mariya A. Prokhorovich, Maria E. Lopatkina, Nikolay A. Skryabin, Igor N. Lebedev, Nikolay B. Rubtsov
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3255 (2022)
Detection and precise genomic mapping of balanced chromosomal abnormalities in patients with impaired fertility or a clinical phenotype represent a challenge for current cytogenomics owing to difficulties with precise breakpoint localization in the r
Externí odkaz:
https://doaj.org/article/4ab33a10696a4c2fab8f87b1b0f92652
Publikováno v:
Almanac of Clinical Medicine. 49:385-395
Rationale: The development of eukaryote genome engineering tools based on CRISPR-Cas programmable bacterial nucleases systems opens wide horizons for gene therapies, human disease cell modeling, as well as investigation into manifestation of disease
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Alexander P. Kalinin, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss, Pp 102703-(2022)
Familial hypercholesterolemia (FH) is an autosomal dominant disorder increasing premature cardiovascular diseases risk due to atherosclerosis. Pathogenic mutations in the LDLR gene cause most FH cases. Available treatments are effective not for all L
Publikováno v:
KnE Life Sciences.
Antisense transcription is an important mechanism of gene expression regulation. Antisense RNAs play a role in mRNA processing, translation and epigenetic modifications of DNA and histones in the locus of their origin, leading to gene silencing. HTT
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Narek A. Tmoyan, Eugeny A. Elisaphenko, Ekaterina S. Zubkova, Aleksei A. Sleptcov, Maria S. Nazarenko, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 60, Iss, Pp 102702-(2022)
The development of cellular models for familial hypercholesterolemia (FH) is an important direction for creating new approaches to atherosclerosis treatment. Pathogenic mutations in the LDLR gene are the main FH source. We generated an iPSC line from