Zobrazeno 1 - 10
of 487
pro vyhledávání: '"Eugenio Uriarte"'
Autor:
Estela Guardado Yordi, Amaury Pérez Martínez, Matteo Radice, Laura Scalvenzi, Reinier Abreu-Naranjo, Eugenio Uriarte, Lourdes Santana, Maria Joao Matos
Publikováno v:
Marine Drugs, Vol 22, Iss 7, p 327 (2024)
The marine kingdom is an important source of a huge variety of scaffolds inspiring the design of new drugs. The complex molecules found in the oceans present a great challenge to organic and medicinal chemists. However, the wide variety of biological
Externí odkaz:
https://doaj.org/article/3ad32ef430644debbaa3b6aa640b751f
Autor:
Lisa Sequeira, Simona Distinto, Rita Meleddu, Marco Gaspari, Andrea Angeli, Filippo Cottiglia, Daniela Secci, Alessia Onali, Erica Sanna, Fernanda Borges, Eugenio Uriarte, Stefano Alcaro, Claudiu T. Supuran, Elias Maccioni
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Tumour associated carbonic anhydrases (CAs) IX and XII have been recognised as potential targets for the treatment of hypoxic tumours. Therefore, considering the high pharmacological potential of the chromene scaffold as selective ligand of the IX an
Externí odkaz:
https://doaj.org/article/608a90cbda4941e490d99c961256b83c
Autor:
Josué Pozo-Martínez, Francisco Salgado, Ana Liempi, Ulrike Kemmerling, Raúl Mera-Adasme, Claudio Olea-Azar, Mauricio Moncada-Basualto, Fernanda Borges, Eugenio Uriarte, Maria João Matos
Publikováno v:
Arabian Journal of Chemistry, Vol 15, Iss 3, Pp 103641- (2022)
American trypanosomiasis or Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, and is considered a neglected disease, being an important problem for public health. Benznidazole (BZN) is the drug used to treat the disease. However,
Externí odkaz:
https://doaj.org/article/4e036ff6ec6c46999cf15afec80a6b4b
Autor:
Lucía Bada, Renato B. Pereira, David M. Pereira, Marta Lores, María Celeiro, Elías Quezada, Eugenio Uriarte, José Gil-Longo, Dolores Viña
Publikováno v:
Molecules, Vol 28, Iss 1, p 351 (2023)
The genus Ulex comprises thirteen accepted species of perennial shrubs in the family Fabaceae. In Galicia (Spain) many of these are considered spontaneous colonizing species, which are easy to establish and maintain. Among them, Ulex gallii Planch. i
Externí odkaz:
https://doaj.org/article/555f0f16757c42d9afef095994bdaabe
Autor:
Francesca Pintus, Sonia Floris, Antonella Fais, Benedetta Era, Amit Kumar, Gianluca Gatto, Eugenio Uriarte, Maria João Matos
Publikováno v:
Molecules, Vol 27, Iss 20, p 6914 (2022)
Skin aging is a progressive biological process of the human body, and it is not only time-dependent. Differently substituted 3-phenylcoumarins proved to efficiently inhibit tyrosinase. In the current work, new substitution patterns have been explored
Externí odkaz:
https://doaj.org/article/907bd0b2d3a740098a0ece1bd05688d1
Publikováno v:
Molecules, Vol 27, Iss 15, p 4901 (2022)
Coumarin is a privilege scaffold in medicinal chemistry. Coumarin derivatives are still an emerging class of highly potent pharmaceutical drugs, best known in the field of antimicrobials and anticoagulants. Thiocoumarins are a particular class of cou
Externí odkaz:
https://doaj.org/article/031e12e267e648dea3413310835e3b58
Autor:
Francisco Salgado, Mauricio Moncada-Basualto, Josue Pozo-Martinez, Ana Liempi, Ulrike Kemmerling, Juan-Diego Maya, Pablo Jaque, Fernanda Borges, Eugenio Uriarte, Maria J. Matos, Claudio Olea-Azar
Publikováno v:
Arabian Journal of Chemistry, Vol 14, Iss 3, Pp 102975- (2021)
Chagas disease is the most widespread contagious tropical disease in Latin America, being an important public health problem. Treatments against this disease are still very ineffective, presenting several side effects. Therefore, the search for alter
Externí odkaz:
https://doaj.org/article/ac8e2a9465f14e32bb336d3f209757ca
Autor:
Osvaldo Yañez, Manuel Isaías Osorio, Eugenio Uriarte, Carlos Areche, William Tiznado, José M. Pérez-Donoso, Olimpo García-Beltrán, Fernando González-Nilo
Publikováno v:
Frontiers in Chemistry, Vol 8 (2021)
The pandemic that started in Wuhan (China) in 2019 has caused a large number of deaths, and infected people around the world due to the absence of effective therapy against coronavirus 2 of the severe acute respiratory syndrome (SARS-CoV-2). Viral ma
Externí odkaz:
https://doaj.org/article/989ba5b657e0463bb4b90c42dfdd77fb
Autor:
Marco Mellado, César González, Jaime Mella, Luis F. Aguilar, Ismail Celik, Fernanda Borges, Eugenio Uriarte, Giovanna Delogu, Dolores Viña, Maria J. Matos
Publikováno v:
Molecules, Vol 27, Iss 3, p 928 (2022)
Monoamine oxidases (MAOs) are attractive targets in drug design. The inhibition of one of the isoforms (A or B) is responsible for modulating the levels of different neurotransmitters in the central nervous system, as well as the production of reacti
Externí odkaz:
https://doaj.org/article/2027809adf9e4501924181c9342d01b3
Autor:
Oscar Collado García, Hans De Winter, Paul Cos, Maria João Matos, Eugenio Uriarte, Gabriel Llaurado Maury, Jorrit De Waele, Glay Chinea Santiago, Enrique Molina
Publikováno v:
Chemistry Proceedings, Vol 8, Iss 1, p 77 (2021)
Anti-HIF flavonoids have been described for their antitumor activity by interfering with a presumed antioxidant mechanism through direct and indirect ways of overexpression of the hypoxia inducible factor (HIF-1α). The aryl hydrocarbon receptor (AhR
Externí odkaz:
https://doaj.org/article/124f230765e44447a37e6b2af96c16e0