Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eugenio Manassero"'
Autor:
Eugenio Manassero, Federica Scarpina, Sofia Tagini, Giulia Concina, Massimo Scacchi, Antonella Pollo, Alessandro Mauro, Benedetto Sacchetti
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Generalizing defensive responses to new stimuli resembling learned threats is an adaptive process within an ever-changing environment. However, evaluation mechanisms excessively biased toward generalization (i.e., overgeneralization) may und
Externí odkaz:
https://doaj.org/article/a5c5f38d830b4fe8be1668311bb50dcc
Autor:
Eugenio Manassero, Giulia Concina, Maria Clarissa Chantal Caraig, Pietro Sarasso, Adriana Salatino, Raffaella Ricci, Benedetto Sacchetti
Publikováno v:
eLife, Vol 13 (2024)
Downregulating emotional overreactions toward threats is fundamental for developing treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for top-down modulatory processes, and despite previous studies adopting
Externí odkaz:
https://doaj.org/article/688b4ebeed02418db3b79e577183a0c6
Autor:
Giulia Concina, Luisella Milano, Annamaria Renna, Eugenio Manassero, Francesca Stabile, Benedetto Sacchetti
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114151- (2024)
Summary: The mammalian brain can store and retrieve memories of related events as distinct memories and remember common features of those experiences. How it computes this function remains elusive. Here, we show in rats that recent memories of two cl
Externí odkaz:
https://doaj.org/article/675a98cd23dd4dc3bc90a660d7644c66
Autor:
Eugenio Manassero, Alessandra Giordano, Erika Raimondo, Alessandro Cicolin, Benedetto Sacchetti
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Past aversive experiences shape our ability to deal with future dangers, through the encoding of implicit and explicit memory traces and through the ability to generalize defensive reactions to new stimuli resembling learned threats. Numerous evidenc
Externí odkaz:
https://doaj.org/article/720ccfa594014461bb6ea0c1521f7572
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
When perceiving new stimuli, organisms need to distinguish between threats versus harmless stimuli. Here, the authors find a set of cells in the lateral amygdala that is required to discriminate or generalize new auditory stimuli based on similarity
Externí odkaz:
https://doaj.org/article/4a24ec399d04407bbfad1e4e66d1588e
Autor:
Eugenio Manassero, Giulia Concina, Maria Clarissa Chantal Caraig, Pietro Sarasso, Adriana Salatino, Raffaella Ricci, Benedetto Sacchetti
Down-regulating emotional overreactions toward threats is fundamental for developing treatments for anxiety and post-traumatic disorders. The prefrontal cortex (PFC) is critical for top-down modulatory processes, and despite previous studies adopting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8f5fd11e975ac95fbad32515c7adb3
https://doi.org/10.1101/2023.02.06.527256
https://doi.org/10.1101/2023.02.06.527256
Autor:
Francesca Stabile, Eugenio Manassero, Benedetto Sacchetti, Luisella Milano, Annamaria Renna, Giulia Concina
Publikováno v:
Cerebral Cortex. 31:5381-5395
Traumatic memories may become less precise over time and lead to the development of fear responses to novel stimuli, a process referred to as time-dependent fear generalization. The conditions that cause the growth of fear generalization over time ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b07e9da3045ae1a502a9f87a1412d76
https://doi.org/10.1093/cercor/bhab165
https://doi.org/10.1093/cercor/bhab165
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Nature Communications
In the presence of new stimuli, it is crucial for survival to react with defensive responses in the presence of stimuli that resemble threats but also to not react with defensive behavior in response to new harmless stimuli. Here, we show that in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5585b5acc90f89f97657ea96e5e369f
https://doaj.org/article/4a24ec399d04407bbfad1e4e66d1588e
https://doaj.org/article/4a24ec399d04407bbfad1e4e66d1588e
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
One strategy to address new potential dangers is to generate defensive responses to stimuli that remind learned threats, a phenomenon called fear generalization. During a threatening experience, the brain encodes implicit and explicit memory traces.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263026515254e7c78e68dab1885f7e19
https://doi.org/10.1038/s41598-019-49751-4
https://doi.org/10.1038/s41598-019-49751-4
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Memories of fearful events can be maintained throughout the lifetime of animals. Here we showed that lesions of the lateral nucleus (LA) performed shortly after training impaired the retention of long-term memories, assessed by the concomitant measur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f062c3e05096950f0f4e882863049763
http://hdl.handle.net/2318/1659885
http://hdl.handle.net/2318/1659885