Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Eugenia Zah"'
Autor:
Eugenia Zah, Eunwoo Nam, Vinya Bhuvan, Uyen Tran, Brenda Y. Ji, Stanley B. Gosliner, Xiuli Wang, Christine E. Brown, Yvonne Y. Chen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
One cause of relapse in cancer patients treated with chimeric antigen receptor (CAR) T cells is the loss of CAR-targeted antigens, which is particularly common in multiple myeloma (MM). Here the authors engineer a CAR recognizing two common MM-associ
Externí odkaz:
https://doaj.org/article/ec2f088f8b5544bbb62387a290932f01
Autor:
Yijun Liu, Eugenia Zah, Carlos Arbelaez, Haejin Kim, Edwige Gros, Ranelle Buck, Kayley Cox, Sungeun Kim, Martina Kopp, Kathryn Henckels, Jennitte Stevens
Publikováno v:
Biotechnology and Bioengineering.
The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00f5b50bcd120d822044346812068041
https://doi.org/10.1158/2326-6066.c.6548624.v1
https://doi.org/10.1158/2326-6066.c.6548624.v1
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Table S1 (primers for cloning of bi-specific CARs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::910b0ab46c0eae3a5619d1efcecd5fcc
https://doi.org/10.1158/2326-6066.22537961.v1
https://doi.org/10.1158/2326-6066.22537961.v1
Fig. S1: CD20 CAR T cells with a long extracellular spacer demonstrate superior in vitro functionality. Fig. S2: CD19-OR-CD20 CARs are efficiently expressed on the surface of primary human T cells. Fig. S3: CRISPR/Cas9-edited Raji cells do not expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3617a3eb965237c25768ec7d9a4e1bd4
https://doi.org/10.1158/2326-6066.22537964
https://doi.org/10.1158/2326-6066.22537964
Autor:
Jennitte Stevens, Yijun Liu, Eugenia Zah, Carlos Arbelaez, Haejin Kim, Edwige Gros, Ranelle Buck, Kayley Cox, Sungeun Kim, Martina Kopp, Kathryn Henckels
Autologous cell therapy has proven to be an effective treatment for hematological malignancies. Cell therapies for solid tumors are on the horizon, however the high cost and complexity of manufacturing these therapies remain a challenge. Routinely us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221325cb4f9466ce0598b7f4be2be8b8
https://doi.org/10.22541/au.165727810.00978327/v1
https://doi.org/10.22541/au.165727810.00978327/v1
Autor:
Christine E. Brown, Uyen Tran, Eugenia Zah, Eunwoo Nam, Brenda Y. Ji, Xiuli Wang, Vinya Bhuvan, Yvonne Y. Chen, Stanley B. Gosliner
Publikováno v:
Nature communications, vol 11, iss 1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Chimeric antigen receptor (CAR)-T cell therapy has shown remarkable clinical efficacy against B-cell malignancies, yet marked vulnerability to antigen escape and tumor relapse exists. Here we report the rational design and optimization of bispecific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c151396e29e87f0556585ecc2e7b36
https://escholarship.org/uc/item/82q2j32v
https://escholarship.org/uc/item/82q2j32v
Publikováno v:
Bioengineering & Translational Medicine
Bioengineering & translational medicine, vol 3, iss 2
Bioengineering & translational medicine, vol 3, iss 2
A chimeric antigen receptor (CAR) that responds to transforming growth factor beta (TGF‐β) enables the engineering of T cells that convert this immunosuppressive cytokine into a potent T‐cell stimulant. However, clinical translation of TGF‐β
Publikováno v:
Cancer immunology research. 4(7)
The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19
Publikováno v:
Zah, E; Lin, MY; Silva-Benedict, A; Jensen, MC; & Chen, YY. (2016). T cells expressing CD19/CD20 bispecific chimeric antigen receptors prevent antigen escape by malignant B cells. Cancer Immunology Research, 4(6), 498-508. doi: 10.1158/2326-6066.CIR-15-0231. UCLA: Retrieved from: http://www.escholarship.org/uc/item/822492mw
Cancer immunology research, vol 4, iss 6
Cancer immunology research, vol 4, iss 6
The adoptive transfer of T cells expressing anti-CD19 chimeric antigen receptors (CARs) has shown remarkable curative potential against advanced B-cell malignancies, but multiple trials have also reported patient relapses due to the emergence of CD19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::871139e70964ab9df2a8165350bafa13
http://www.escholarship.org/uc/item/822492mw
http://www.escholarship.org/uc/item/822492mw