Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Eugenia Z. Ong"'
Autor:
Jenny G. Low, Ruklanthi de Alwis, Shiwei Chen, Shirin Kalimuddin, Yan Shan Leong, Tania Ken Lin Mah, Natalene Yuen, Hwee Cheng Tan, Summer L. Zhang, Jean X. Y. Sim, Yvonne F. Z. Chan, Ayesa Syenina, Jia Xin Yee, Eugenia Z. Ong, Rose Sekulovich, Brian B. Sullivan, Kelly Lindert, Sean M. Sullivan, Pad Chivukula, Steven G. Hughes, Eng Eong Ooi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be another option for disease prevention if demonstrated to be safe and immunogenic. Phase
Externí odkaz:
https://doaj.org/article/8f3f3b68e6d74f248a8f293e7fa6c66a
Autor:
Eugenia Z. Ong, Jia Xin Yee, Justin S. G. Ooi, Ayesa Syenina, Ruklanthi de Alwis, Shiwei Chen, Jean X. Y. Sim, Shirin Kalimuddin, Yan Shan Leong, Yvonne F. Z. Chan, Rose Sekulovich, Brian M. Sullivan, Kelly Lindert, Sean B. Sullivan, Pad Chivukula, Steven G. Hughes, Jenny G. Low, Eng Eong Ooi, Kuan Rong Chan
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-9 (2022)
Abstract Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA vaccine is the self-amplifying mRNA (sa-mRNA) vaccine, which encodes an alphavirus rep
Externí odkaz:
https://doaj.org/article/f164a1f335254aad9b2305f3200a7da5
Autor:
Shirin Kalimuddin, Yvonne F. Z. Chan, October M. Sessions, Kuan Rong Chan, Eugenia Z. Ong, Jenny G. Low, Antonio Bertoletti, Eng Eong Ooi
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Vaccination induces an adaptive immune response that protects against infectious diseases. A defined magnitude of adaptive immune response that correlates with protection from the disease of interest, or correlates of protection (CoP), is useful for
Externí odkaz:
https://doaj.org/article/4c9fd9a30d404461b2d2081e9e38a4e2
Autor:
Kuan Rong Chan, Clara W.T. Koh, Dorothy H.L. Ng, Shijie Qin, Justin S.G. Ooi, Eugenia Z. Ong, Summer L.X. Zhang, Huizhen Sam, Shirin Kalimuddin, Jenny G.H. Low, Eng Eong Ooi
Publikováno v:
EBioMedicine, Vol 89, Iss , Pp 104472- (2023)
Summary: Background: Mass vaccination has dramatically reduced the incidence of severe COVID-19, with most cases now presenting as self-limiting upper respiratory tract infections. However, those with co-morbidities, the elderly and immunocompromised
Externí odkaz:
https://doaj.org/article/70461e7192624ff09b631c2b2187ac19
Autor:
Wy Ching Ng, Swee Sen Kwek, Bo Sun, Meisam Yousefi, Eugenia Z. Ong, Hwee Cheng Tan, Andreas S. Puschnik, Kuan Rong Chan, Yaw Shin Ooi, Eng Eong Ooi
Publikováno v:
Open Biology, Vol 12, Iss 12 (2022)
The four dengue viruses (DENVs) have evolved multiple mechanisms to ensure its survival. Among these mechanisms is the ability to regulate its replication rate, which may contribute to avoiding premature immune activation that limit infection dissemi
Externí odkaz:
https://doaj.org/article/6458694551b142398b420ec817c446de
Autor:
Ayesa Syenina, Esther S. Gan, Justin Z. N. Toh, Ruklanthi de Alwis, Lowell Z. Lin, Christine Y. L. Tham, Jia Xin Yee, Yan Shan Leong, Huizhen Sam, Charlene Cheong, Yii Ean Teh, Ian L. E. Wee, Dorothy H. L. Ng, Kuan Rong Chan, Jean X. Y. Sim, Shirin Kalimuddin, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi
Publikováno v:
PLoS Biology, Vol 20, Iss 5 (2022)
Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various COVID-19 vaccines currently in use, the mRNA vaccines have shown remarkable effectiveness. However
Externí odkaz:
https://doaj.org/article/ecfcaa6f536c4157ba77ecce6b10848c
Autor:
Clement Yau, Esther Shuyi Gan, Swee Sen Kwek, Hwee Cheng Tan, Eugenia Z. Ong, Noor Zayanah Hamis, Laura Rivino, Kuan Rong Chan, Satoru Watanabe, Subhash G. Vasudevan, Eng Eong Ooi
Publikováno v:
EBioMedicine, Vol 61, Iss , Pp 103028- (2020)
Background: The emergence of Zika virus (ZIKV) as an important cause of congenital and childhood developmental disorders presents another challenge to global health. Efforts to develop a Zika vaccine have begun although vaccine development against fl
Externí odkaz:
https://doaj.org/article/1aaa19728d0f4e10a0c4451030eb9e76
Autor:
Swee Sen Kwek, Satoru Watanabe, Kuan Rong Chan, Eugenia Z. Ong, Hwee Cheng Tan, Wy Ching Ng, Mien T. X. Nguyen, Esther S. Gan, Summer L. Zhang, Kitti W. K. Chan, Jun Hao Tan, October M. Sessions, Menchie Manuel, Julien Pompon, Camillus Chua, Sharifah Hazirah, Karl Tryggvason, Subhash G. Vasudevan, Eng Eong Ooi
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
A Zika virus (ZIKV) vaccine should provide long-lasting immunity, which may be achieved with a live-attenuated vaccine. Here, Kwek et al. select an interferon-restricted, attenuated ZIKV variant and evaluate replication and immunogenicity in mouse an
Externí odkaz:
https://doaj.org/article/2200a4c3d0464f52b6e961470788a10a
Autor:
null Wy Ching Ng, null Swee Sen Kwek, null Bo Sun, null Meisam Yousefi, null Eugenia Z. Ong, null Hwee Cheng Tan, null Andreas S. Puschnik, null Kuan Rong Chan, null Yaw Shin Ooi, null Eng Eong Ooi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9686c61117dd1d2a462eee114cf33bd3
https://doi.org/10.1098/rsob.220227/v2/response1
https://doi.org/10.1098/rsob.220227/v2/response1
Publikováno v:
Current Treatment Options in Infectious Diseases
Purpose of Review At the turn of the nineteenth century, yellow fever (YF) was considered the most dangerous infectious disease with high case fatality. Subsequent, mass vaccination campaigns coupled with widespread elimination of the YF mosquito vec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c05c57cc77cab63186ff55cfb8e06a
https://doi.org/10.1007/s40506-020-00237-2
https://doi.org/10.1007/s40506-020-00237-2