Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Eugenia V. Broude"'
Autor:
Elena K. Kokinos, Sergey A. Tsymbal, Anastasia V. Galochkina, Svetlana A. Bezlepkina, Julia V. Nikolaeva, Sofia O. Vershinina, Anna A. Shtro, Victor V. Tatarskiy, Alexander A. Shtil, Eugenia V. Broude, Igor B. Roninson, Marina Dukhinova
Publikováno v:
Viruses, Vol 15, Iss 6, p 1292 (2023)
Hyperactivation of the immune system remains a dramatic, life-threatening complication of viral and bacterial infections, particularly during pneumonia. Therapeutic approaches to counteract local and systemic outbreaks of cytokine storm and to preven
Externí odkaz:
https://doaj.org/article/19250ae8ae084306bf89ae07e22bdecc
Autor:
Amanda C. Sharko, Chang-Uk Lim, Martina S. J. McDermott, Chuck Hennes, Kingsavanh P. Philavong, Tiffanie Aiken, Victor V. Tatarskiy, Igor B. Roninson, Eugenia V. Broude
Publikováno v:
Cells, Vol 10, Iss 1, p 144 (2021)
Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequen
Externí odkaz:
https://doaj.org/article/c8a8be021b1e434fad24bdd39e2993bd
Autor:
Martina S.J. McDermott, Amanda C. Sharko, Jessica Munie, Susannah Kassler, Theresa Melendez, Chang-uk Lim, Eugenia V. Broude
Publikováno v:
Cells, Vol 9, Iss 3, p 638 (2020)
CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen receptor-positive (ER+) breast cancers have been reported to be uniquely sensitive to the CDK7 inhibitor THZ
Externí odkaz:
https://doaj.org/article/64799c7355f84d01997e8616e6544aba
Autor:
Mengqian Chen, Jing Li, Jiaxin Liang, Zanshé S. Thompson, Katie Kathrein, Eugenia V. Broude, Igor B. Roninson
Publikováno v:
Cells, Vol 8, Iss 11, p 1413 (2019)
CDK8/19 kinases, which mediate transcriptional reprogramming, have become an active target for cancer drug discovery. Several small-molecule CDK8/19 inhibitors showed in vivo efficacy and two have entered clinical trials, with no significant toxiciti
Externí odkaz:
https://doaj.org/article/f622691e8eef42439140685559054837
Publikováno v:
Cells, Vol 8, Iss 10, p 1208 (2019)
Cell-based assays for CDK8/19 inhibition are not easily defined, since there are no known cellular functions unique to these kinases. To solve this problem, we generated derivatives of 293 cells with CRISPR knockout of one or both of CDK8 and CDK19.
Externí odkaz:
https://doaj.org/article/6209016a158c420290e1a7a6f1e25b80
Autor:
Igor B. Roninson, Balázs Győrffy, Zachary T. Mack, Alexander A. Shtil, Michael S. Shtutman, Mengqian Chen, Eugenia V. Broude
Publikováno v:
Cells, Vol 8, Iss 8, p 821 (2019)
CDK8 and CDK19 Mediator kinases are transcriptional co-regulators implicated in several types of cancer. Small-molecule CDK8/19 inhibitors have recently entered or are entering clinical trials, starting with breast cancer and acute myeloid leukemia (
Externí odkaz:
https://doaj.org/article/bee188e8d9974110980495eb02bcfbec
Autor:
Igor B. Roninson, Eugenia V. Broude, Maria Marjorette Pena, Karthikeyan Mythreye, Hippokratis Kiaris, Chang-Uk Lim, Vimala Kaza, Serena Altilia, Alexander A. Chumanevich, Daniel Hughes, Mengqian Chen, Jiaxin Liang
Supplemental data for SMAD4, CTNNB1 and STAT1 knockdown and microRNA analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d2f6053055b9147476992ef6f3f843
https://doi.org/10.1158/0008-5472.22419000.v1
https://doi.org/10.1158/0008-5472.22419000.v1
Autor:
Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh
Inhibin is a heterodimeric TGFβ family ligand that is expressed in many cancers and is a selective biomarker for ovarian cancers; however, its tumor-specific functions remain unknown. Here, we demonstrate that the α subunit of inhibin (INHA), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0964e26d2798fd26b9ba222f278b1c36
https://doi.org/10.1158/0008-5472.c.6509868.v1
https://doi.org/10.1158/0008-5472.c.6509868.v1
Autor:
Igor B. Roninson, Eugenia V. Broude, Maria Marjorette Pena, Karthikeyan Mythreye, Hippokratis Kiaris, Chang-Uk Lim, Vimala Kaza, Serena Altilia, Alexander A. Chumanevich, Daniel Hughes, Mengqian Chen, Jiaxin Liang
List of key resources and reagents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b9423659ed95be4c29b7feec9b9bc8
https://doi.org/10.1158/0008-5472.22418994
https://doi.org/10.1158/0008-5472.22418994
Autor:
Karthikeyan Mythreye, Nam Y. Lee, Eugenia V. Broude, Balázs Győrffy, Nadine Hempel, Tapasya Srivastava, Prabhjot Kaur, Shrikant Pradhan, Victoria Alers, Ben Horst, Laura M. Jenkins, Priyanka Singh
Growth curves of (i) HMEC-1 and MEEC cells in the presence or absence of 100pM recombinant Inhibin A over 7 days or (ii) HMEC-1 migration through fibronectin coated transwells for 6 hrs towards control serum free media or media containing 300 pM reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5cbc9886f4412f12248899fc31bece5
https://doi.org/10.1158/0008-5472.22417524
https://doi.org/10.1158/0008-5472.22417524