Grooved poly(lactide-co-trimethylene carbonate) substrates in tenogenic media maintain human tendon derived cell phenotype in culture – A preliminary report✰

Autor: Sofia Ribeiro, Eugenia Pugliese, Stefanie H. Korntner, Emanuel M. Fernandes, Manuela E. Gomes, Rui L. Reis, Alan O'Riordan, Stephen Kearns, Jack L. Kelly, Manus Biggs, Yves Bayon, Dimitrios I. Zeugolis

Publikováno v: Biomedical Engineering Advances, Vol 6, Iss , Pp 100098- (2023)

Tissue engineering strategies for tendon repair and regeneration rely heavily on the use of tendon derived cells. However, these cells frequently undergo phenotypic drift in vitro, which compromises their therapeutic potential. In order to maintain t

Externí odkaz: https://doaj.org/article/4bbc8c49c86e4384b796d34f1db7d478

Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Autor: Christina N.M. Ryan, Eugenia Pugliese, Naledi Shologu, Diana Gaspar, Peadar Rooney, Md Nahidul Islam, Alan O'Riordan, Manus J. Biggs, Matthew D. Griffin, Dimitrios I. Zeugolis

Publikováno v: Biomaterials and Biosystems, Vol 11, Iss , Pp 100079- (2023)

Due to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physiochemical cu

Externí odkaz: https://doaj.org/article/0c197c3228874bf5bd13c62a5869656e

Development of three-layer collagen scaffolds to spatially direct tissue-specific cell differentiation for enthesis repair

Autor: Eugenia Pugliese, Ignacio Sallent, Sofia Ribeiro, Alexandre Trotier, Stefanie H. Korntner, Yves Bayon, Dimitrios I. Zeugolis

Publikováno v: Materials Today Bio, Vol 19, Iss , Pp 100584- (2023)

Enthesis repair remains a challenging clinical indication. Herein, a three-layer scaffold composed of a tendon-like layer of collagen type I, a fibrocartilage-like layer of collagen type II and a bone-like layer of collagen type I and hydroxyapatite,

Externí odkaz: https://doaj.org/article/05877c7403a242a5aacdae22cda0acd8

The synergistic effect of physicochemical in vitro microenvironment modulators in human bone marrow stem cell cultures

Autor: Christina N.M. Ryan, Eugenia Pugliese, Naledi Shologu, Diana Gaspar, Peadar Rooney, Md Nahidul Islam, Alan O'Riordan, Manus J. Biggs, Matthew D. Griffin, Dimitrios I. Zeugolis

Publikováno v: Biomaterials advances. 144

Modern bioengineering utilises biomimetic cell culture approaches to control cell fate during in vitro expansion. In this spirit, herein we assessed the influence of bidirectional surface topography, substrate rigidity, collagen type I coating and ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b9cb2b27cfef257ecb90e06115fa44
https://pubmed.ncbi.nlm.nih.gov/36455498

Modulation of stem cell response using biodegradable polyester films with different stiffness

Autor: Dimitrios I. Zeugolis, Stefanie Korntner, Manuela E. Gomes, Sofia Ribeiro, Rui L. Reis, Eugenia Pugliese, Emanuel M. Fernandes, Yves Bayon

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Biomedical Engineering Advances, Vol 2, Iss, Pp 100007-(2021)

Matrix stiffness is a crucial regulator of cell fate in both in vitro and in vivo setting. Although studies with non-degradable polymers have contributed to our understanding of the influence of rigidity on cell response, very little work has been co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a22e272f3d9c3dc7c488e26f56c8f77
https://hdl.handle.net/1822/75576