Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Eugenia Migliavacca"'
Autor:
Mary C. Stephenson, Jamie X.M. Ho, Eugenia Migliavacca, Maria Kalimeri, Neerja Karnani, Subhasis Banerji, John J. Totman, Jerome N. Feige, Reshma A. Merchant, Stacey K.H. Tay
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 3, Pp 1482-1494 (2023)
Abstract Background Mitochondrial dysfunction has been implicated in sarcopenia. 31P magnetic resonance spectroscopy (MRS) enables non‐invasive measurement of adenosine triphosphate (ATP) synthesis rates to probe mitochondrial function. Here, we as
Externí odkaz:
https://doaj.org/article/db4a386da10847ff80503a8a94989940
Autor:
Jörg Rahnenführer, Riccardo De Bin, Axel Benner, Federico Ambrogi, Lara Lusa, Anne-Laure Boulesteix, Eugenia Migliavacca, Harald Binder, Stefan Michiels, Willi Sauerbrei, Lisa McShane, for topic group “High-dimensional data” (TG9) of the STRATOS initiative
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-54 (2023)
Abstract Background In high-dimensional data (HDD) settings, the number of variables associated with each observation is very large. Prominent examples of HDD in biomedical research include omics data with a large number of variables such as many mea
Externí odkaz:
https://doaj.org/article/4341909edf664733b9e0a8f2c0eedbe3
Autor:
Elie Antoun, Emma S. Garratt, Andrea Taddei, Mark A. Burton, Sheila J. Barton, Phil Titcombe, Leo D. Westbury, Alicia Baczynska, Eugenia Migliavacca, Jerome N. Feige, Holly E. Sydall, Elaine Dennison, Richard Dodds, Helen C. Roberts, Peter Richardson, Avan A. Sayer, Sarah Shaw, Cyrus Cooper, Joanna D. Holbrook, Harnish P. Patel, Keith M. Godfrey, Karen A. Lillycrop, the EpiGen Global Research Consortium
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 240-253 (2022)
Abstract Background Sarcopenia is the age‐related loss of muscle mass, strength, and function. Epigenetic processes such as DNA methylation, which integrate both genetic and environmental exposures, have been suggested to contribute to the developm
Externí odkaz:
https://doaj.org/article/cb246371e61f4db3b368469abfa5c136
Autor:
Elie Antoun, Eugenia Migliavacca, Emma S Garratt, Sheila J Barton, Phil Titcombe, Leo D Westbury, Alica Baczynska, Richards Dodds, Helen C Roberts, Avan A Sayer, Sarah Shaw, H.E. Syddall, Allan Sheppard, Craig McFarlane, Neerja Karnani, Terrence Forrester, Cyrus Cooper, Jerome N Feige, Harnish P Patel, Keith M Godfrey, Karen A Lillycrop, the EpiGen Global Research Consortium
Publikováno v:
JCSM Rapid Communications, Vol 4, Iss 2, Pp 207-221 (2021)
Abstract Background Despite increasing knowledge of the pathogenesis of muscle ageing, the molecular mechanisms are poorly understood. Based on an expression analysis of muscle biopsies from older Caucasian men, we undertook an in‐depth analysis of
Externí odkaz:
https://doaj.org/article/a5b9c209ed974c5ab4dd714c72918127
Autor:
Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent mode
Externí odkaz:
https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
Autor:
Giulia Lizzo, Eugenia Migliavacca, Daniela Lamers, Adrien Frézal, John Corthesy, Gerard Vinyes-Parès, Nabil Bosco, Leonidas G. Karagounis, Ulrike Hövelmann, Tim Heise, Maximilian von Eynatten, Philipp Gut
Publikováno v:
Frontiers in Aging, Vol 3 (2022)
Glycine and cysteine are non-essential amino acids that are required to generate glutathione, an intracellular tripeptide that neutralizes reactive oxygen species and prevents tissue damage. During aging glutathione demand is thought to increase, but
Externí odkaz:
https://doaj.org/article/3cb8b258691640c6b12f20b7acfe4d07
Autor:
Omid Mashinchian, Xiaotong Hong, Joris Michaud, Eugenia Migliavacca, Gregory Lefebvre, Christophe Boss, Filippo De Franceschi, Emmeran Le Moal, Jasmin Collerette-Tremblay, Joan Isern, Sylviane Metairon, Frederic Raymond, Patrick Descombes, Nicolas Bouche, Pura Muñoz-Cánoves, Jerome N Feige, C Florian Bentzinger
Publikováno v:
eLife, Vol 11 (2022)
Sustained exposure to a young systemic environment rejuvenates aged organisms and promotes cellular function. However, due to the intrinsic complexity of tissues it remains challenging to pinpoint niche-independent effects of circulating factors on s
Externí odkaz:
https://doaj.org/article/e06534e7b8fc4105bcfcb17a74fd6563
Autor:
Eugenia Migliavacca, Stacey K. H. Tay, Harnish P. Patel, Tanja Sonntag, Gabriele Civiletto, Craig McFarlane, Terence Forrester, Sheila J. Barton, Melvin K. Leow, Elie Antoun, Aline Charpagne, Yap Seng Chong, Patrick Descombes, Lei Feng, Patrice Francis-Emmanuel, Emma S. Garratt, Maria Pilar Giner, Curtis O. Green, Sonia Karaz, Narasimhan Kothandaraman, Julien Marquis, Sylviane Metairon, Sofia Moco, Gail Nelson, Sherry Ngo, Tony Pleasants, Frederic Raymond, Avan A. Sayer, Chu Ming Sim, Jo Slater-Jefferies, Holly E. Syddall, Pei Fang Tan, Philip Titcombe, Candida Vaz, Leo D. Westbury, Gerard Wong, Wu Yonghui, Cyrus Cooper, Allan Sheppard, Keith M. Godfrey, Karen A. Lillycrop, Neerja Karnani, Jerome N. Feige
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Sarcopenia is the loss of muscle mass and strength associated with physical disability during ageing. Here, the authors analyse muscle biopsies from 119 patients with sarcopenia and age-matched controls of different ethnic groups and find transcripti
Externí odkaz:
https://doaj.org/article/4c3223da69ca4524955a319f2fa0179d
Autor:
Loïc Dayon, Antonio Núñez Galindo, Jérôme Wojcik, Ornella Cominetti, John Corthésy, Aikaterini Oikonomidi, Hugues Henry, Martin Kussmann, Eugenia Migliavacca, India Severin, Gene L. Bowman, Julius Popp
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)
Abstract Background Altered proteome profiles have been reported in both postmortem brain tissues and body fluids of subjects with Alzheimer disease (AD), but their broad relationships with AD pathology, amyloid pathology, and tau-related neurodegene
Externí odkaz:
https://doaj.org/article/5a300155e9c6438b9f6a17f924c566a5
Autor:
Alice Pannérec, Eugenia Migliavacca, Antonio De Castro, Joris Michaud, Sonia Karaz, Laurence Goulet, Serge Rezzi, Tze Pin Ng, Nabil Bosco, Anis Larbi, Jerome N. Feige
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 1, Pp 41-52 (2018)
Abstract Background Physical frailty and loss of mobility in elderly individuals lead to reduced independence, quality of life, and increased mortality. Vitamin B12 deficiency has been linked to several age‐related chronic diseases, including in th
Externí odkaz:
https://doaj.org/article/9b4379f363fe4524b07dffd4fb8e4c15