Dopamine and Citicoline-Co-Loaded Solid Lipid Nanoparticles as Multifunctional Nanomedicines for Parkinson’s Disease Treatment by Intranasal Administration

Autor: Stefano Castellani, Giorgia Natalia Iaconisi, Francesca Tripaldi, Vito Porcelli, Adriana Trapani, Eugenia Messina, Lorenzo Guerra, Cinzia Di Franco, Giuseppe Maruccio, Anna Grazia Monteduro, Filomena Corbo, Sante Di Gioia, Giuseppe Trapani, Massimo Conese

Publikováno v: Pharmaceutics, Vol 16, Iss 8, p 1048 (2024)

This work aimed to evaluate the potential of the nanosystems constituted by dopamine (DA) and the antioxidant Citicoline (CIT) co-loaded in solid lipid nanoparticles (SLNs) for intranasal administration in the treatment of Parkinson disease (PD). Suc

Externí odkaz: https://doaj.org/article/1f1ab735209c4911b1f6e1e0eb162bb7

Genetic inactivation of the Carnitine/Acetyl-Carnitine mitochondrial carrier of Yarrowia lipolytica leads to enhanced odd-chain fatty acid production

Autor: Eugenia Messina, Camilla Pires de Souza, Claudia Cappella, Simona Nicole Barile, Pasquale Scarcia, Isabella Pisano, Luigi Palmieri, Jean-Marc Nicaud, Gennaro Agrimi

Publikováno v: Microbial Cell Factories, Vol 22, Iss 1, Pp 1-16 (2023)

Abstract Background Mitochondrial carriers (MCs) can deeply affect the intracellular flux distribution of metabolic pathways. The manipulation of their expression level, to redirect the flux toward the production of a molecule of interest, is an attr

Externí odkaz: https://doaj.org/article/ddbe986bdb884c52a1d41ac8ac7b4a04

Sustainable chemo-enzymatic preparation of enantiopure (R)-β-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous 'click' cycloaddition reaction in deep eutectic solvents

Autor: Mariaelena Di Biase, Eugenia Messina, Francesco Lavolpe, Paola Vitale, Vito Capriati, Francesca Valerio, Isabella Pisano, Gennaro Agrimi, Filippo Maria Perna

Publikováno v: Reaction Chemistry & Engineering 5 (2020): 859–864. doi:10.1039/d0re00067a
info:cnr-pdr/source/autori:Vitale P.; Lavolpe F.; Valerio F.; Di Biase M.; Perna F.M.; Messina E.; Agrimi G.; Pisano I.; Capriati V./titolo:Sustainable chemo-enzymatic preparation of enantiopure (: R)-beta-hydroxy-1,2,3-triazoles via lactic acid bacteria-mediated bioreduction of aromatic ketones and a heterogeneous "click" cycloaddition reaction in deep eutectic solvents/doi:10.1039%2Fd0re00067a/rivista:Reaction Chemistry & Engineering/anno:2020/pagina_da:859/pagina_a:864/intervallo_pagine:859–864/volume:5

Enantiomerically pure (R)-beta-hydroxy-1,2,3-triazole derivatives, which are important beta-blocker analogues, have been synthesized by exploiting an unusual Prelog enantioselective reduction of aromatic azido ketones by whole cells of a lactic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c725811f2e2070d7f5928b198d316651
https://doi.org/10.1039/d0re00067a

Biochemical and Functional Characterization of a Mitochondrial Citrate Carrier in Arabidopsis thaliana

Autor: Danielle Santos Brito, Gennaro Agrimi, Nicole Linka, Maria Gabriella Bitetto, Luigi Palmieri, Lennart Charton, Eugenia Messina, Toshihiro Obata, Adriano Nunes-Nesi, Marcel Viana Pires, Dominik Brilhaus, Alisdair R. Fernie, Ferdinando Palmieri, Carolina P. Nascimento, Jaciara Lana-Costa, Jorge Luis Pérez-Díaz, Elias Feitosa-Araujo, Wagner L. Araújo, Vito Porcelli, Andreas P.M. Weber

Publikováno v: Biochemical Journal

A homolog of the mitochondrial succinate/fumarate carrier from yeast (Sfc1p) has been found in the Arabidopsis genome, named AtSFC1. The AtSFC1 gene was expressed in Escherichia coli, and the gene product was purified and reconstituted in liposomes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103dec8da187e4859db0aef92ff4bf64
https://hdl.handle.net/21.11116/0000-0006-65D5-8