Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Eugenia M.C. Jones"'
Autor:
Eugenia M.C. Jones, Maria C. Marchetto, Michael McLachlan, Fred H. Gage, Shani Stern, Imran H. Quraishi, Kile P. Mangan, Michael R. Mercier, Syed R. Ali, Leonard K. Kaczmarek, Yalan Zhang
Publikováno v:
The Journal of Neuroscience. 39:7438-7449
Mutations in the KCNT1 (Slack, K(Na)1.1) sodium-activated potassium channel produce severe epileptic encephalopathies. Expression in heterologous systems has shown that the disease-causing mutations give rise to channels that have increased current a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ead739d012b1e0afd54d1e331fdd73a
https://doi.org/10.1523/jneurosci.1628-18.2019
https://doi.org/10.1523/jneurosci.1628-18.2019
Publikováno v:
Stem Cell Research, Vol 44, Iss, Pp-(2020)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fca66fceb36faa44218fcb6a04654b9
https://pubmed.ncbi.nlm.nih.gov/32151950
https://pubmed.ncbi.nlm.nih.gov/32151950
Autor:
Gail A. Robertson, H. Holkham, Eugenia M.C. Jones, J-P Valentin, Chris E. Pollard, Najah Abi-Gerges
Publikováno v:
British Journal of Pharmacology. 164:419-432
BACKGROUND AND PURPOSE The majority of human ether-a-go-go-related gene (hERG) screens aiming to minimize the risk of drug-induced long QT syndrome have been conducted using heterologous systems expressing the hERG 1a subunit, although both hERG 1a a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44e97cd94cb1a04634dfdd0f13050def
https://doi.org/10.1111/j.1476-5381.2011.01378.x
https://doi.org/10.1111/j.1476-5381.2011.01378.x
Autor:
Eugenia M.C. Jones, Imran H. Quraishi, Kile P. Mangan, Elisabeth Enghofer, Leonard K. Kaczmarek, Yalan Zhang, Benjamin Meline, Christian Kannemeier, Michael McLachlan, Christopher W. McMahon
Publikováno v:
Biophysical Journal. 114:487a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a497839b333bbc1fb3909a1773cb42d
https://doi.org/10.1016/j.bpj.2017.11.2674
https://doi.org/10.1016/j.bpj.2017.11.2674
Publikováno v:
Journal of Biological Chemistry. 283:3702-3707
Defects in the trafficking of subunits encoded by the human ether-à-go-go-related gene (hERG1) can lead to catastrophic arrhythmias and sudden cardiac death due to a reduction in I(Kr)-mediated repolarization. Native I(Kr) channels are composed of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0615ac638c596860d392393e3d54306
https://doi.org/10.1074/jbc.m708999200
https://doi.org/10.1074/jbc.m708999200
Publikováno v:
Journal of Biological Chemistry. 282:9874-9882
Alternate transcripts of the human ether-à-go-go-related gene (hERG1) encode two subunits, hERG 1a and 1b, which form potassium channels regulating cardiac repolarization, neuronal firing frequency, and neoplastic cell growth. The 1a and 1b subunits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd86f956dd5e343a04ee338bb01ca1ae
https://doi.org/10.1074/jbc.m610875200
https://doi.org/10.1074/jbc.m610875200
Autor:
Brad Swanson, Lucas Chase, Michael McLachlan, Nathan Meyer, Benjamin Meline, Eugenia M.C. Jones, Susan DeLaura, Tom Burke, Coby B. Carlson, Kile P. Mangan
Publikováno v:
Biophysical Journal. 108(2)
The sodium-activated potassium channel Slack, encoded by the gene KCNT1, is expressed in neurons throughout many brain regions, including the frontal cortex, and mediates a sodium-sensitive potassium current (IKNa). This outward current regulates neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45094fedd7c1497167e7eca587cecbb9
Publikováno v:
Journal of Biological Chemistry. 279:44690-44694
Previous studies suggest native cardiac IKr channels are composed of alpha subunits encoded solely by the 1a transcript of the ERG1 gene. Using isoform-specific ERG1 antibodies, we have new evidence that subunits encoded by an alternate transcript, E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d862c96f4af66968ea69b340ccd9db
https://doi.org/10.1074/jbc.m408344200
https://doi.org/10.1074/jbc.m408344200
Publikováno v:
Genetic Engineering & Biotechnology News. 36:14-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da20a098c3ab0174142f9f84cc07583
https://doi.org/10.1089/gen.36.01.09
https://doi.org/10.1089/gen.36.01.09
Autor:
Coby B. Carlson, Kile P. Mangan, Eugenia M.C. Jones, Imran Quaraishi, Christopher W. McMahon, Leonard K. Kaczmarek, Michael McLachlan, Yalan Zhang, Tom Burke, Benjamin Meline
Publikováno v:
Biophysical Journal. 112:547a
Epilepsy is a disturbance in the electrical activity of the brain manifested via countless etiologies. 65 million individuals suffer from epilepsy and one-third of these individuals live with uncontrollable seizures because no known pharmacological t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f0ffa48f7502e778358f2cfea8cb1dd
https://doi.org/10.1016/j.bpj.2016.11.2954
https://doi.org/10.1016/j.bpj.2016.11.2954