Výsledky vyhledávání - "Eugenia Karousou"

Hyaluronan Produced by Smooth Muscle Cells Plays a Critical Role in Neointima Formation

Autor: Sara Deleonibus, Manuela Viola, Davide Vigetti, Giancarlo De Luca, Alberto Passi, Eugenia Karousou

Publikováno v: Conference Papers in Science. 2014:1-5

Large body of evidence supports the idea that microenvironment plays a critical role in several pathologies including atherosclerosis and cancer. The amount of hyaluronan (HA) is involved in the microenvironment alterations and the concentration of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34a773fd4964714d6c9a0eee9fc0dd46
https://doi.org/10.1155/2014/408427

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Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

Autor: Eugenia Karousou, Berit Bernert, Koichi Nishitsuka, Spyros S. Skandalis, Helena Porsch, Paraskevi Heldin

Publikováno v: Connective Tissue Research. 49:215-218

Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae0d5a7579ca5c0dc2b4cb23ca2abc2
https://doi.org/10.1080/03008200802143323

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Natural antisense transcript for hyaluronan synthase 2 (HAS2-AS1) induces transcription of HAS2 via protein O-GlcNAcylation

Autor: Eugenia Karousou, Dona C. Love, Maria Grandoch, Timothy Bowen, Giancarlo De Luca, Alexander Oberhuber, Raffaella Cinquetti, Sara Deleonibus, Davide Vigetti, Vincent C. Hascall, Paola Moretto, Manuela Viola, Alberto Passi, Jens W. Fischer, Maria Luisa D'Angelo, John A. Hanover

Publikováno v: The Journal of biological chemistry. 289(42)

Changes in the microenvironment organization within vascular walls are critical events in the pathogenesis of vascular pathologies, including atherosclerosis and restenosis. Hyaluronan (HA) accumulation into artery walls supports vessel thickening an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b7c7761f78e9afc2ec1615d9138b7c9
https://pubmed.ncbi.nlm.nih.gov/25645084

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Hyaluronan: biosynthesis and signaling

Autor: Eugenia Karousou, Giancarlo De Luca, Sara Deleonibus, Davide Vigetti, Alberto Passi, Manuela Viola

Publikováno v: Biochimica et biophysica acta. 1840(8)

Background Hyaluronan is a critical component of extracellular matrix with several different roles. Besides the contribution to the tissue hydration, mechanical properties and correct architecture, hyaluronan plays important biological functions inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd28e85b2014eb9cb061a20784522ce1
https://pubmed.ncbi.nlm.nih.gov/24513306

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Role of UDP-N-Acetylglucosamine (GlcNAc) and O-GlcNAcylation of Hyaluronan Synthase 2 in the Control of Chondroitin Sulfate and Hyaluronan Synthesis

Autor: Davide Vigetti, Paola Moretto, Barbara Bartolini, Alberto Passi, Markku Tammi, Eugenia Karousou, Manuela Viola, Giancarlo De Luca, Sara Deleonibus, Vincent C. Hascall

Hyaluronan (HA) is a glycosaminoglycan present in most tissue microenvironments that can modulate many cell behaviors, including proliferation, migration, and adhesive proprieties. In contrast with other glycosaminoglycans, which are synthesized in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0160805c1fe78d243a1f7f8f80370829
http://hdl.handle.net/11383/1775116

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Glycosaminoglycans as key molecules in atherosclerosis: the role of versican and hyaluronan

Autor: Nikolaos Tsilimingas, Achilleas D. Theocharis, Athanasia P. Asimakopoulou, Filippos Triposkiadis, Ioannis Kanakis, Alberto Passi, Nikos K. Karamanos, Eugenia Karousou, Dimos Karangelis

Publikováno v: Current medicinal chemistry. 17(33)

Cardiovascular disease is the largest cause of death in Western societies and it primarily results from atherosclerosis of large and medium-sized vessels. Atherosclerosis leads to myocardial infarction, when it occurs in the coronary arteries, or str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::348ae9a77b8fcc8b9dd1a0d10211dee9
https://pubmed.ncbi.nlm.nih.gov/20939824

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The activity of hyaluronan synthase 2 is regulated by dimerization and ubiquitination

Autor: Aino Ruusala, Paraskevi Heldin, Ulf Hellman, Spyros S. Skandalis, Alberto Passi, Trias Asteriou, Carl-Henrik Heldin, Hidetoshi Yamashita, Eugenia Karousou, Masaru Kamiryo

Publikováno v: The Journal of biological chemistry. 285(31)

Hyaluronan is a component of the extracellular matrix, which affects tissue homeostasis. In this study, we investigated the regulatory mechanisms of one of the hyaluronan-synthesizing enzymes, HAS2. Ectopic expression of Flag- and 6myc-HAS2 in COS-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2148b523e3ec03bd33ab0a966fcfa236
https://pubmed.ncbi.nlm.nih.gov/20507985

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Growth Factor Regulation of Hyaluronan Deposition in Malignancies

Autor: Eugenia Karousou, Spyros S. Skandalis, Paraskevi Heldin

Publisher Summary This chapter focuses on the extracellular molecule hyaluronan, the signals that regulate its synthesis and deposition, as well as its role in cellular communication. Because of its remarkable physicochemical properties and hygroscop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ff9c70db510a5d78a8190205b3ce695
https://doi.org/10.1016/b978-012374178-3.10003-1

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