Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Eugenia H Goulding"'
Autor:
Tracy M Clement, Christopher B Geyer, William D Willis, Eugenia H Goulding, Srijana Upadhyay, Edward M Eddy
Publikováno v:
Biology of Reproduction. 108:447-464
The formation of fertilisation-competent sperm requires spermatid morphogenesis (spermiogenesis), a poorly understood program that involves complex coordinated restructuring and specialised cytoskeletal structures. A major class of cytoskeletal regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::077eec13f86a2bae89c278818dbc1fd9
https://doi.org/10.1093/biolre/ioad001
https://doi.org/10.1093/biolre/ioad001
Autor:
Manas K. Ray, Gregory Scott, Lucas Van Gorder, Shih Heng Chen, Erica Scappini, Negin P. Martin, Mitzie Walker, Maura Schwartz, Charles Romeo, Eugenia H. Goulding
Publikováno v:
Biochem Biophys Res Commun
Gene delivery to fertilized eggs is often the first step in creation of transgenic animals, CRISPR knock-out, or early developmental studies. The zona pellucida, a hardened glycoprotein matrix surrounding the mammalian fertilized eggs, often complica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c291cccd40061b77b737a24c92dfbd53
https://doi.org/10.1016/j.bbrc.2020.03.026
https://doi.org/10.1016/j.bbrc.2020.03.026
Autor:
Edward M. Eddy, Kwanhee Kim, Brenda M. Murdoch, Eugenia H. Goulding, Natalie R Peer, Sze Ming Law
Publikováno v:
Endocrinology. 159:3403-3420
Retinoic acid receptor α (RARA), a retinoic acid–dependent transcription factor, is expressed in both somatic and germ cells of the testis. Rara-null male mice with global Rara mutations displayed severely degenerated testis and infertility phenot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba47a79eda44e2ab14b391cbb462ec0a
https://doi.org/10.1210/en.2018-00533
https://doi.org/10.1210/en.2018-00533
Autor:
Bryan A. Niedenberger, Ellen K. Velte, Nicholas D. Serra, Jonathan T. Busada, Kenneth K Cook, Eugenia H. Goulding, William D. Willis, Edward M. Eddy, Christopher B. Geyer
Publikováno v:
Reproduction. 152:379-388
We previously described a novel germ cell-specific X-linkedreproductivehomeoboxgene (Rhox13) that is upregulated at the level of translation in response to retinoic acid (RA) in differentiating spermatogonia and preleptotene spermatocytes. We hypothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc9f5054f90218d59179137338dac4d
https://doi.org/10.1530/rep-16-0268
https://doi.org/10.1530/rep-16-0268
Autor:
Shih Heng Chen, Thomas M. Porter, Amanda R. Mathew, Erica Scappini, Eugenia H. Goulding, Page Myers, Mitzie Walker, Negin P. Martin, Charles Romeo, Lucas Van Gorder, Artiom Gruzdev
Publikováno v:
Journal of Visualized Experiments.
Lentiviruses are efficient vectors for gene delivery to mammalian cells. Following transduction, the lentiviral genome is stably incorporated into the host chromosome and is passed on to progeny. Thus, they are ideal vectors for creation of stable ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f766b287cbe139fc4b5d72d41eb7268
https://doi.org/10.3791/58327-v
https://doi.org/10.3791/58327-v
Autor:
Page Myers, Shih Heng Chen, Negin P. Martin, Eugenia H. Goulding, Mitzie Walker, Charles Romeo, Artiom Gruzdev, Lucas Van Gorder, Amanda R. Mathew, Thomas M. Porter
Lentiviruses are highly efficient vehicles for delivering genes into cells. They readily transduce primary and immortalized cells in vivo and in vitro. Genes delivered by lentiviruses are incorporated and replicated as part of their host genome and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2b1d44bd507b753d6576fc479f4ac0
https://europepmc.org/articles/PMC5990369/
https://europepmc.org/articles/PMC5990369/
Autor:
Eugenia H. Goulding, James W. Putney, Edward M. Eddy, Gary S. Bird, Kyathanahalli S. Janardhan, Felicity M. Davis, Connie A. Cummings, Diane M. D’Agostin
Publikováno v:
Cell calcium. 59(4)
Store-operated calcium entry (SOCE) is an important Ca(2+) influx pathway in somatic cells. In addition to maintaining endoplasmic reticulum (ER) Ca(2+) stores, Ca(2+) entry through store-operated channels regulates essential signaling pathways in nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9fbfb236f9e3724b3a8c38729d6a806
https://pubmed.ncbi.nlm.nih.gov/26969191
https://pubmed.ncbi.nlm.nih.gov/26969191
Autor:
John F. Couse, Edward M. Eddy, Katherine J. Hamilton, Kenneth S. Korach, Wendy N. Jefferson, Vicki L. Davis, Eugenia H. Goulding, Sheri L. Rea, Katie M. Gallagher, Bill C. Bullock, Retha R. Newbold
Publikováno v:
Reproductive Toxicology. 34:512-521
ERΔ3 transgenic mice expressing a dominant negative estrogen receptor α (ERα) variant lacking the second zinc finger in the DNA binding domain were developed to examine its potential to inhibit estrogen action in vivo. To investigate if ERΔ3 expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9feb440634ad0252a0257df0ada63e1d
https://doi.org/10.1016/j.reprotox.2012.08.005
https://doi.org/10.1016/j.reprotox.2012.08.005
Autor:
Kenneth S. Korach, Eugenia H. Goulding, Sylvia C. Hewitt, Katherine J. Hamilton, Noriko Nakamura, Edward M. Eddy
Publikováno v:
Journal of Endocrinology. 207:281-288
Disruption of the Esr1 gene encoding estrogen receptor α (ERα) by insertion of a neomycin resistance gene (neo) into exon 2 (αERKO mice) was shown previously to cause infertility in male mice. While full-length ERα protein was not expressed in α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07df77cc83cf81efe7834c8e88702987
https://doi.org/10.1677/joe-10-0290
https://doi.org/10.1677/joe-10-0290
Autor:
G. Barrie Kitto, William D. Willis, Polina V. Danshina, Deborah A. O'Brien, Qunsheng Dai, Edward M. Eddy, Christopher B. Geyer, Eugenia H. Goulding, John R. McCarrey
Publikováno v:
Biology of Reproduction. 82:136-145
Phosphoglycerate kinase 2 (PGK2), an isozyme that catalyzes the first ATP-generating step in the glycolytic pathway, is encoded by an autosomal retrogene that is expressed only during spermatogenesis. It replaces the ubiquitously expressed phosphogly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd1f5cd437808aa4a7168aa16c0ad8f
https://doi.org/10.1095/biolreprod.109.079699
https://doi.org/10.1095/biolreprod.109.079699