Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Eugenia G. Giannopoulou"'
Autor:
Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption. The mammalian target of rapamycin (mT
Externí odkaz:
https://doaj.org/article/94ddd12e176541f7acf745405b1c2a85
Autor:
Ying Liu, Eugenia G. Giannopoulou, Duancheng Wen, Ilaria Falciatori, Olivier Elemento, C. David Allis, Shahin Rafii, Marco Seandel
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Spermatogonial stem cells (SSCs) spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here, the authors reveal the dynamics of bivalent histone H3-lysine4 and -lysine27 methylation signatures at somatic gene promoters
Externí odkaz:
https://doaj.org/article/9be23f62cde04e9eb501aca199051c3d
Autor:
Katerina Hatzi, Yanwen Jiang, Chuanxin Huang, Francine Garrett-Bakelman, Micah D. Gearhart, Eugenia G. Giannopoulou, Paul Zumbo, Kevin Kirouac, Srividya Bhaskara, Jose M. Polo, Matthias Kormaksson, Alexander D. MacKerell, Jr., Fengtian Xue, Christopher E. Mason, Scott W. Hiebert, Gilbert G. Prive, Leandro Cerchietti, Vivian J. Bardwell, Olivier Elemento, Ari Melnick
Publikováno v:
Cell Reports, Vol 4, Iss 3, Pp 578-588 (2013)
The BCL6 transcriptional repressor is required for the development of germinal center (GC) B cells and diffuse large B cell lymphomas (DLBCLs). Although BCL6 can recruit multiple corepressors, its transcriptional repression mechanism of action in nor
Externí odkaz:
https://doaj.org/article/9cd7d9fe59494c7fbf2a87fbc864e290
Autor:
Pei-Chun Lin, Eugenia G. Giannopoulou, Kyung Park, Juan Miguel Mosquera, Andrea Sboner, Ashutosh K. Tewari, Levi A. Garraway, Himisha Beltran, Mark A. Rubin, Olivier Elemento
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 4, Pp 373-383 (2013)
Although prostate cancer (PCa) is the second leading cause of cancer death among men worldwide, not all men diagnosed with PCa will die from the disease. A critical challenge, therefore, is to distinguish indolent PCa from more advanced forms to guid
Externí odkaz:
https://doaj.org/article/79d6bb5348bf4c74a1fc2e45d5e70f50
Autor:
Eugenia G. Giannopoulou, Susan Li, Xiaoyu Hu, Baohong Zhao, Christine H. Miller, Lionel B. Ivashkiv
Publikováno v:
Journal of Clinical Investigation. 132
Osteoclastogenesis requires activation of RANK signaling as well as costimulatory signals from immunoreceptor tyrosine-based activation motif-containing (ITAM-containing) receptors/adaptors, predominantly tyrosine kinase-binding proteins DAP12 and Fc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6ba870eee44ca70ecd13bd88ee5707
https://doi.org/10.1172/jci161196
https://doi.org/10.1172/jci161196
Autor:
Baohong Zhao, Shiaoching Gong, Gabriel Lopez-Berestein, Eugenia G. Giannopoulou, Anil K. Sood, Ren Xu, Matthew B. Greenblatt, Zhonghao Deng, Liang Zhao, Kazuki Inoue, David G. Kirsch, Yufan Chen, Lingegowda S. Mangala
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications
Targeting microRNAs recently shows significant therapeutic promise; however, such progress is underdeveloped in treatment of skeletal diseases with osteolysis, such as osteoporosis and rheumatoid arthritis (RA). Here, we identified miR-182 as a key o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755b0fc801d4c373c593812179957e9b
http://link.springer.com/article/10.1038/s41467-018-06446-0
http://link.springer.com/article/10.1038/s41467-018-06446-0
Autor:
Richard M. Siegel, Kyung-Hyun Park-Min, Aleksandra Ivovic, Sung Ho Park, Lionel B. Ivashkiv, Eugenia G. Giannopoulou, Laura T. Donlin
Publikováno v:
Nature reviews. Rheumatology. 15(6)
Rheumatic diseases have complex aetiologies that are not fully understood, which makes the study of pathogenic mechanisms in these diseases a challenge for researchers. Next-generation sequencing (NGS) and related omics technologies, such as transcri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b37f60f9740780fd8118c2ddc765bbe
https://pubmed.ncbi.nlm.nih.gov/31000790
https://pubmed.ncbi.nlm.nih.gov/31000790
Autor:
Uma Chandrasekaran, Chien-Huan Weng, Casey T. Weaver, Govind Bhagat, Eugenia G. Giannopoulou, Alessandra B. Pernis, Rolf Jessberger, Woelsung Yi, Sanjay Gupta, Yurii Chinenov
Publikováno v:
Arthritis & Rheumatology. 68:1454-1466
Objective Treg cells need to acquire an effector phenotype to function in settings of inflammation. Whether effector Treg cells can limit disease severity in lupus is unknown. Interferon regulatory factor 4 (IRF-4) is an essential controller of effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6df601d1b391b67f19dc6bd166c59d89
https://doi.org/10.1002/art.39599
https://doi.org/10.1002/art.39599
Autor:
Duancheng Wen, Marco Seandel, C. David Allis, Shahin Rafii, Ying Liu, Olivier Elemento, Eugenia G. Giannopoulou, Ilaria Falciatori
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications
Spermatogonial stem and progenitor cells (SSCs) generate adult male gametes. During in vitro expansion, these unipotent murine cells spontaneously convert to multipotent adult spermatogonial-derived stem cells (MASCs). Here we investigate this conver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b032feed7280d7e7bd28a856d7c07571
https://doaj.org/article/9be23f62cde04e9eb501aca199051c3d
https://doaj.org/article/9be23f62cde04e9eb501aca199051c3d
Autor:
Xiaoyu Hu, Xiaodi Su, Hui Liu, Charles M. Rice, Lionel B. Ivashkiv, Gunnar Rätsch, Yingpu Yu, Justin R. Cross, Yi Zhong, Eugenia G. Giannopoulou
Publikováno v:
Nature immunology
Interferon-γ (IFN-γ) primes macrophages for enhanced microbial killing and inflammatory activation by Toll-like receptors (TLRs), but little is known about the regulation of cell metabolism or mRNA translation during this priming. We found that IFN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66cf76976a38dbd83968340ffe00c584
https://doi.org/10.1038/ni.3205
https://doi.org/10.1038/ni.3205