Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Eugene Y Wu"'
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1003961 (2014)
During DNA replication, DNA polymerases follow an induced fit mechanism in order to rapidly distinguish between correct and incorrect dNTP substrates. The dynamics of this process are crucial to the overall effectiveness of catalysis. Although X-ray
Externí odkaz:
https://doaj.org/article/e4ac890b21c4473b81c2bcb6d807384b
Publikováno v:
The FASEB Journal. 32
Autor:
Eugene Y, Wu, Angela K, Hilliker
Publikováno v:
Journal of molecular microbiology and biotechnology. 27(6)
Rifampicin is an effective antibiotic against mycobacterial and other bacterial infections, but resistance readily emerges in laboratory and clinical settings. We screened Escherichia coli for rifampicin resistance and identified numerous mutations t
Autor:
Connie C.W. Hsia, D. Merrill Dane, Harrieth Wagner, Eugene Y. Wu, Robert L. Johnson, Peter D. Wagner, Aaron S. Estrera
Publikováno v:
Journal of Applied Physiology. 103:1496-1505
In athletic animals the spleen induces acute polycythemia by dynamic contraction that releases red blood cells into the circulation in response to increased O2 demand and metabolic stress; when energy demand is relieved, the polycythemia is rapidly r
Autor:
Richard T. Hogg, D. Merrill Dane, Aaron S. Estrera, Deborah C. Hogg, Robert L. Johnson, Eugene Y. Wu, Connie C.W. Hsia
Publikováno v:
Journal of Applied Physiology. 101:289-297
The spleen acts as an erythrocyte reservoir in highly aerobic species such as the dog and horse. Sympathetic-mediated splenic contraction during exercise reversibly enhances convective O2 transport by increasing hematocrit, blood volume, and O2-carry
Autor:
Eugene Y. Wu, Harrieth Wagner, Connie C.W. Hsia, Robert L. Johnson, Aaron S. Estrera, Peter D. Wagner
Publikováno v:
Journal of Applied Physiology. 95:1370-1378
After pneumonectomy (Pnx), mechanical strain on the remaining lung is an important signal for adaptation. To examine how mechanical lung strain alters gas exchange adaptation after Pnx, we replaced the right lung of adult dogs with a custom-shaped in
Publikováno v:
Journal of Applied Physiology. 82:196-202
Wu, Eugene Y., Khalid W. Barazanji, and Robert L. Johnson, Jr. Sources of error in a-aDO2 calculated from blood stored in plastic and glass syringes. J. Appl. Physiol. 82(1): 196–202, 1997.—We studied the effects of time delay on blood gases, pH,
Publikováno v:
Journal of Applied Physiology. 80:1304-1312
To determine the temporal progression and magnitude of functional compensation in immature dogs raised to maturity after extensive lung resection, we performed right pneumonectomy (R-Pnx) or right thoracotomy without pneumonectomy (Sham) in matched f
Publikováno v:
Journal of Applied Physiology. 80:1014-1020
In dogs, maximal O2 uptake (VO2max) per kilogram of body weight is two- to threefold that in humans; the difference cannot be explained solely by differences in structural features between species. We compared the functional recruitment of pulmonary
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 89(5)
Pneumonectomy (PNX) leads to chronic asymmetric ventilatory loading of respiratory muscles (RM). We measured RM energy requirements during exercise from RM blood flow (Q˙) using a fluorescent microsphere technique in dogs that had undergone right PN