Výsledky vyhledávání - "Eugene W. Schwilke"

Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers

Autor: Deanna L. Kelly, Jennifer R. Schroeder, Denis Bonnet, Eugene W. Schwilke, Marilyn A. Huestis, Catherine Ortemann-Renon, David A. Gorelick, David M. Schwope, Robert S. Goodwin

Publikováno v: The American Journal on Addictions. 22:510-514

Background and Objectives Δ9-tetrahydrocannabinol (THC) promotes sleep in animals; clinical use of THC is associated with somnolence. Human laboratory studies of oral THC have not shown consistent effects on sleep. We prospectively evaluated self-re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17f5dd768a66ba09bb15ed676e6df841
https://doi.org/10.1111/j.1521-0391.2013.12003.x

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Predictive model accuracy in estimating last Δ9-tetrahydrocannabinol (THC) intake from plasma and whole blood cannabinoid concentrations in chronic, daily cannabis smokers administered subchronic oral THC

Autor: Eugene W. Schwilke, Marilyn A. Huestis, Deanna L. Kelly, David A. Gorelick, David M. Schwope, Erin L. Karschner, Robert S. Goodwin

Publikováno v: Drug and Alcohol Dependence. 125:313-319

Determining time since last cannabis/Δ9-tetrahydrocannabinol (THC) exposure is important in clinical, workplace, and forensic settings. Mathematical models calculating time of last exposure from whole blood concentrations typically employ a theoreti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b53e54a232f655676e5984e5d69940d
https://doi.org/10.1016/j.drugalcdep.2012.03.005

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Oral Fluid and Plasma Cannabinoid Ratios after Around-the-Clock Controlled Oral Δ9-Tetrahydrocannabinol Administration

Autor: Robert S. Goodwin, David A. Gorelick, Eugene W. Schwilke, Marilyn A. Huestis, William D. Darwin, David M. Schwope, Deanna L. Kelly, Garry Milman

Publikováno v: Clinical Chemistry. 57:1597-1606

BACKGROUND Oral fluid (OF) testing is increasingly important for drug treatment, workplace, and drugged-driving programs. There is interest in predicting plasma or whole-blood concentrations from OF concentrations; however, the relationship between t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee95f1c93262bb9e0d3eb7f11506ec1f
https://doi.org/10.1373/clinchem.2011.169490

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Cannabinoids and metabolites in expectorated oral fluid after 8 days of controlled around-the-clock oral THC administration

Autor: Garry Milman, Eugene W. Schwilke, David M. Schwope, Robert S. Goodwin, Deana L. Kelly, Allan J. Barnes, David A. Gorelick, Marilyn A. Huestis

Publikováno v: Analytical and Bioanalytical Chemistry. 401:599-607

Oral fluid (OF) is an increasingly accepted matrix for drug testing programs, but questions remain about its usefulness for monitoring cannabinoids. Expectorated OF specimens (n = 360) were obtained from 10 adult daily cannabis smokers before, during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5055db4fbc1d9a3528795d67430e2584
https://doi.org/10.1007/s00216-011-5066-4

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Differentiating new cannabis use from residual urinary cannabinoid excretion in chronic, daily cannabis users

Autor: Harrison G. Pope, Marilyn A. Huestis, William D. Darwin, David A. Gorelick, C. Nora Chiang, Jean Lud Cadet, Eugene W. Schwilke, Rod G. Gullberg

Publikováno v: Addiction. 106:499-506

Aims To develop and validate empirically a mathematical model for identifying new cannabis use in chronic, daily cannabis smokers. Design Models were based on urinary creatinine‐normalized (CN) cannabinoid excretion in chronic cannabis smokers. Set

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcec070eb2e2bc039de91f31deadb878
https://doi.org/10.1111/j.1360-0443.2010.03228.x

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Disposition of Cannabinoids in Oral Fluid after Controlled Around-the-Clock Oral THC Administration

Autor: Marilyn A. Huestis, William D. Darwin, Garry Milman, David A. Gorelick, Deanna L. Kelly, Allan J. Barnes, David M. Schwope, Eugene W. Schwilke, Robert S. Goodwin

Publikováno v: Clinical Chemistry. 56:1261-1269

BACKGROUND Oral fluid, a promising alternative matrix for drug monitoring in clinical and forensic investigations, offers noninvasive sample collection under direct observation. Cannabinoid distribution into oral fluid is complex and incompletely cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bebebd6947513d8cc9adbd959a83be9
https://doi.org/10.1373/clinchem.2009.141853

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Δ9-Tetrahydrocannabinol (THC), 11-Hydroxy-THC, and 11-Nor-9-carboxy-THC Plasma Pharmacokinetics during and after Continuous High-Dose Oral THC

Autor: Erin L. Karschner, Eugene W. Schwilke, Robert S. Goodwin, David M. Schwope, William D. Darwin, David A. Gorelick, Marilyn A. Huestis, Ross H. Lowe, Deanna L. Kelly

Publikováno v: Clinical Chemistry. 55:2180-2189

Background: Δ9-Tetrahydrocannabinol (THC) is the primary psychoactive constituent of cannabis and an active cannabinoid pharmacotherapy component. No plasma pharmacokinetic data after repeated oral THC administration are available. Methods: Six adul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8dfe37afcbb7781757ce8781a5244d4
https://doi.org/10.1373/clinchem.2008.122119

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Do Δ9-tetrahydrocannabinol concentrations indicate recent use in chronic cannabis users?

Autor: Eugene W. Schwilke, Marilyn A. Huestis, Harrison G. Pope, W. David Darwin, Jean Lud Cadet, Ronald I. Herning, Erin L. Karschner, Ross H. Lowe

Publikováno v: Addiction. 104:2041-2048

Aims To quantify blood Δ9-tetrahydrocannabinol (THC) concentrations in chronic cannabis users over 7 days of continuous monitored abstinence. Participants Twenty-five frequent, long-term cannabis users resided on a secure clinical research unit at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d5cfb625eb96e3194cd51369a3c6985
https://doi.org/10.1111/j.1360-0443.2009.02705.x

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Intra- and Intersubject Whole Blood/Plasma Cannabinoid Ratios Determined by 2-Dimensional, Electron Impact GC-MS with Cryofocusing

Autor: Erin L. Karschner, Marilyn A. Huestis, Ann Marie Gordon, Ronald I. Herning, Eugene W. Schwilke, Ross H. Lowe, Jean Lud Cadet

Publikováno v: Clinical Chemistry. 55:1188-1195

Background: Whole-blood concentrations of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH) are approximately half of those in plasma due to high plasma protein binding and poor cannabinoid distribution in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f741be1cb44bbc3e07abce2310c413
https://doi.org/10.1373/clinchem.2008.114405

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Excretion of Methamphetamine and Amphetamine in Human Sweat Following Controlled Oral Methamphetamine Administration

Autor: Eugene W. Schwilke, Eric T. Moolchan, Allan J. Barnes, Marilyn A. Huestis, Sherri L. Kacinko, Edward J. Cone, Michael L. Smith

Publikováno v: Clinical Chemistry. 54:172-180

Background: Understanding methamphetamine (MAMP) and amphetamine (AMP) excretion in sweat is important for interpreting sweat and hair testing results in judicial, workplace, and drug treatment settings. Methods: Participants (n = 8) received 4 10-mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5ba38c5ae1b73817130700a78ba784
https://doi.org/10.1373/clinchem.2007.092304

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