Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Eugene Uh"'
Autor:
Elizabeth S McKenney, Michelle Sargent, Hameed Khan, Eugene Uh, Emily R Jackson, Géraldine San Jose, Robin D Couch, Cynthia S Dowd, Monique L van Hoek
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e38167 (2012)
Bacteria, plants, and algae produce isoprenoids through the methylerythritol phosphate (MEP) pathway, an attractive pathway for antimicrobial drug development as it is present in prokaryotes and some lower eukaryotes but absent from human cells. The
Externí odkaz:
https://doaj.org/article/06a91359bad242128ad771b2c63ac854
Autor:
Kriti Arora, Clifton E. Barry, Jinwoo Lee, Patricia S. Tsang, Claire J. MacKenzie, Stephanie S. Dawes, Paul G. Wyatt, Tracy Bayliss, Laura A. T. Cleghorn, Eugene Uh, Bernardo Ochoa-Montaño, Peter C. Ray, Tom L. Blundell, Helena I. Boshoff, Valerie Mizrahi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Volume 58, no. 11, p. 6962–6965, 2014, [https://doi.org/10.1128/AAC.03486-14][1]. Page 6963, left column, second paragraph: the following text in lines 5 to 10 should be deleted. “We deleted this oxidase in H37Rv by replacing a 221-bp MluI fragme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83f8d3d47d145fa69f69d374a7347223
https://doi.org/10.1128/aac.01429-17
https://doi.org/10.1128/aac.01429-17
Autor:
Patricia S. Tsang, Tracy Bayliss, Clifton E. Barry, Peter C. Ray, Claire J. MacKenzie, Valerie Mizrahi, Jinwoo Lee, Helena I. Boshoff, Eugene Uh, Bernardo Ochoa-Montaño, Stephanie S. Dawes, Kriti Arora, Paul G. Wyatt, Laura A. T. Cleghorn, Tom L. Blundell
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6962-6965
We report here a series of five chemically diverse scaffolds that have in vitro activities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc 1 complex in Mycobacterium tuberculosis in a strain-dependent manner. Deletio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8873ff9a62be7411ce9549af65eda550
https://doi.org/10.1128/aac.03486-14
https://doi.org/10.1128/aac.03486-14
Publikováno v:
Journal of Clinical Oncology. 37:1543-1543
1543 Background: Lung cancer is the leading cause of cancer death in the United States (US) and worldwide. Chest X-ray (CXR) is ineffective in reducing lung cancer mortality. National Lung Cancer Screening Trail (NLST) reported 20% reduction in morta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ce7476cb311e29f5dce24ad617b57bc
https://doi.org/10.1200/jco.2019.37.15_suppl.1543
https://doi.org/10.1200/jco.2019.37.15_suppl.1543
Autor:
Cynthia S. Dowd, Géraldine San Jose, Emily R. Jackson, Robin E. B. Lee, Marcus M. Maddox, Eugene Uh, Helena I. Boshoff, Richard E. Lee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6973-6976
The nonmevalonate pathway (NMP) of isoprene biosynthesis is an exciting new route toward novel antibiotic development. Inhibitors against several enzymes in this pathway are currently under examination. A significant liability of many of these agents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f4f0ecaed77a34499240e7d7cd535c
https://doi.org/10.1016/j.bmcl.2011.09.123
https://doi.org/10.1016/j.bmcl.2011.09.123
Publikováno v:
American Journal of Gastroenterology. 113:S1623
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1e8da9c9c922eeb40b75fc30941f079
https://doi.org/10.14309/00000434-201810001-02945
https://doi.org/10.14309/00000434-201810001-02945
Autor:
Géraldine, San Jose, Emily R, Jackson, Eugene, Uh, Chinchu, Johny, Amanda, Haymond, Lindsay, Lundberg, Chelsea, Pinkham, Kylene, Kehn-Hall, Helena I, Boshoff, Robin D, Couch, Cynthia S, Dowd
Publikováno v:
MedChemComm. 4(7)
In most bacteria, the nonmevalonate pathway is used to synthesize isoprene units. Dxr, the second step in the pathway, catalyzes the NADPH-dependent reductive isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol-4-phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ccb60b234b040b5948954a973cd54d2
https://pubmed.ncbi.nlm.nih.gov/23914289
https://pubmed.ncbi.nlm.nih.gov/23914289
Autor:
Tathagata Mukherjee, Gwendolyn A. Marriner, Todd D. Gruber, Laura E. Via, Eugene Uh, Kriti Arora, Matthew W. Carroll, Clifton E. Barry, Amit Nayyar, Sharon Y. Wong, Kathleen England, Rachel L. Edwards, Jinwoo Lee, Inhee Choi, Helena I. Boshoff
Publikováno v:
Topics in Medicinal Chemistry ISBN: 9783642234866
The development of effective chemotherapy for the treatment of tuberculosis (TB) began in the 1940s and has been reinvigorated recently due to concern regarding the emergence of highly drug-resistant TB strains. This chapter explores the medicinal ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f863d7e92ec2d507e0800ec8fed6eea6
https://doi.org/10.1007/7355_2011_13
https://doi.org/10.1007/7355_2011_13
Autor:
Cynthia S. Dowd, Amanda Haymond, Chelsea Pinkham, Eugene Uh, Géraldine San Jose, Emily R. Jackson, Robin D. Couch, Lindsay Lundberg, Helena I. Boshoff, Chinchu Johny, Kylene Kehn-Hall
Publikováno v:
MedChemComm. 4:1099
In most bacteria, the nonmevalonate pathway is used to synthesize isoprene units. Dxr, the second step in the pathway, catalyzes the NADPH-dependent reductive isomerization of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol-4-phosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b67840fe7a99091a4e604b30723e1d47
https://doi.org/10.1039/c3md00085k
https://doi.org/10.1039/c3md00085k