Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Eugene Tkachenko"'
Autor:
Bart Weijts, Edgar Gutierrez, Semion K. Saikin, Ararat J. Ablooglu, David Traver, Alex Groisman, Eugene Tkachenko
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The mechanisms of sensing of blood flow and responses to it in vascular remodelling are poorly understood. Here, the authors show that in zebrafish blood flow controls both the fate determination of individual blood vessels and the arterial versus ve
Externí odkaz:
https://doaj.org/article/b1794bd622bc45d3a2fefd0e655fefd7
Autor:
Eugene Tkachenko, Edgar Gutierrez, Semion K. Saikin, Per Fogelstrand, Chungho Kim, Alex Groisman, Mark H. Ginsberg
Publikováno v:
Biology Open, Vol 2, Iss 10, Pp 1007-1012 (2013)
Summary Hemodynamic shear stresses cause endothelial cells (ECs) to polarize in the plane of the flow. Paradoxically, under strong shear flows, ECs disassemble their primary cilia, common sensors of shear, and thus must use an alternative mechanism o
Externí odkaz:
https://doaj.org/article/9d18b97969174f8a9e1968dde94bfaf9
Autor:
Eugene Tkachenko, Dan Tse, Olga Sideleva, Sophie J Deharvengt, Marcus R Luciano, Yan Xu, Caitlin L McGarry, John Chidlow, Paul F Pilch, William C Sessa, Derek K Toomre, Radu V Stan
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32655 (2012)
PV1 protein is an essential component of stomatal and fenestral diaphragms, which are formed at the plasma membrane of endothelial cells (ECs), on structures such as caveolae, fenestrae and transendothelial channels. Knockout of PV1 in mice results i
Externí odkaz:
https://doaj.org/article/69c4454d534d49dd93a397fab9fce813
Autor:
Edgar Gutierrez, Eugene Tkachenko, Achim Besser, Prithu Sundd, Klaus Ley, Gaudenz Danuser, Mark H Ginsberg, Alex Groisman
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23807 (2011)
Substrate rigidity profoundly impacts cellular behaviors such as migration, gene expression, and cell fate. Total Internal Reflection Fluorescence (TIRF) microscopy enables selective visualization of the dynamics of substrate adhesions, vesicle traff
Externí odkaz:
https://doaj.org/article/fe8a94e219b74f8cba0599eecf4c3113
Publikováno v:
Zebrafish. 14:489-491
We describe the design, fabrication, and applications of a four-well dish for imaging of the trunk of larval zebrafish. The dish facilitates immobilization of anesthetized zebrafish larvae, with their tails gently pushed against a microscope cover gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5bee39351140e0322a2dbc1e4ffc3b
https://doi.org/10.1089/zeb.2016.1406
https://doi.org/10.1089/zeb.2016.1406
Autor:
Alex Groisman, Eugene Tkachenko, Edgar Gutierrez, Semion K. Saikin, Bart Weijts, David Traver, Ararat J. Ablooglu
Arteries and veins are formed independently by different types of endothelial cells (ECs). In vascular remodeling, arteries and veins become connected and some arteries become veins. It is unclear how ECs in transforming vessels change their type and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af824940cf4127047f7b0177a8736538
https://doi.org/10.1101/095307
https://doi.org/10.1101/095307
Autor:
Chungho Kim, Edgar Gutierrez, Per Fogelstrand, Alex Groisman, Eugene Tkachenko, Semion K. Saikin, Mark H. Ginsberg
Publikováno v:
Biology Open, Vol 2, Iss 10, Pp 1007-1012 (2013)
Biology Open
Biology Open
Summary Hemodynamic shear stresses cause endothelial cells (ECs) to polarize in the plane of the flow. Paradoxically, under strong shear flows, ECs disassemble their primary cilia, common sensors of shear, and thus must use an alternative mechanism o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebcf6578955ff523b02c2f958c462ac
https://doi.org/10.1242/bio.20134622
https://doi.org/10.1242/bio.20134622
Publikováno v:
Scientific reports, vol 6, iss 1
Scientific Reports
Scientific Reports
Multiple functions of cells cultured on flat substrates have been shown to depend on the elastic modulus of the substrate, E, with the dependence being strongest in a physiological range of soft tissues, corresponding to E from 0.1 to 100 kPa. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cebe3a4a62054217e0974623035092f
https://doi.org/10.1101/040048
https://doi.org/10.1101/040048
Publikováno v:
Development. 137:3449-3458
Integrin αV can form heterodimers with several β subunits to mediate cell-cell and cell-extracellular matrix interactions. During zebrafish gastrulation, αV is expressed maternally and zygotically. Here, we used a morpholino-mediated αV knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc9a2fcbd58186ea7d40d7e43bda901
https://doi.org/10.1242/dev.045310
https://doi.org/10.1242/dev.045310
Autor:
Phu Nguyen, William B. Kiosses, Lawrence E. Goldfinger, Edgar Gutierrez, Rebecca A. Stockton, Kayoko Kinbara, Mark H. Ginsberg, Shu Chien, Eleni Tzima, Alex Groisman, Eugene Tkachenko
Publikováno v:
Circulation Research. 103:177-185
Vascular endothelial cells respond to laminar shear stress by aligning in the direction of flow, a process which may contribute to atheroprotection. Here we report that localized α4 integrin phosphorylation is a mechanism for establishing the direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d1f5334992cecc1170f2085f7f619
https://doi.org/10.1161/circresaha.108.176354
https://doi.org/10.1161/circresaha.108.176354