1,4-dihydroxy quininib activates ferroptosis pathways in metastatic uveal melanoma and reveals a novel prognostic biomarker signature

Autor: Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey, Breandán N. Kennedy

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-18 (2024)

Abstract Uveal melanoma (UM) is an ocular cancer, with propensity for lethal liver metastases. When metastatic UM (MUM) occurs, as few as 8% of patients survive beyond two years. Efficacious treatments for MUM are urgently needed. 1,4-dihydroxy quini

Externí odkaz: https://doaj.org/article/a9bd8fb17964483389a107365ee28f49

Impaired Airway Epithelial Barrier Integrity in Response to Stenotrophomonas maltophilia Proteases, Novel Insights Using Cystic Fibrosis Bronchial Epithelial Cell Secretomics

Autor: Kevin Molloy, Gerard Cagney, Eugene T. Dillon, Kieran Wynne, Catherine M. Greene, Noel G. McElvaney

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Stenotrophomonas maltophilia is a Gram-negative opportunistic pathogen that can chronically colonize the lungs of people with cystic fibrosis (CF) and is associated with lethal pulmonary hemorrhage in immunocompromised patients. Its secreted virulenc

Externí odkaz: https://doaj.org/article/93040cf73c8940c29ae58c8535d37c60

Yeast β‐glucan improves insulin sensitivity and hepatic lipid metabolism in mice humanized with obese type 2 diabetic gut microbiota

Autor: Kathleen A. J. Mitchelson, Tam T. T. Tran, Eugene T. Dillon, Klara Vlckova, Sabine M. Harrison, Alexandra Ntemiri, Katie Cunningham, Irene Gibson, Francis M. Finucane, Eibhlís M. O'Connor, Helen M. Roche, Paul W. O'Toole

Publikováno v: Mitchelson, K A J, Tran, T T T, Dillon, E T, Vlckova, K, Harrison, S M, Ntemiri, A, Cunningham, K, Gibson, I, Finucane, F M, O'Connor, E M, Roche, H M & O'Toole, P W 2022, ' Yeast β-glucan improves insulin sensitivity and hepatic lipid metabolism in mice humanized with obese type 2 diabetic gut microbiota ', Molecular Nutrition & Food Research, vol. 66, no. 22, 2100819 . https://doi.org/10.1002/mnfr.202100819

ScopeGut microbiota alterations are associated with obesity and type 2 diabetes. Yeast β-glucans are potential modulators of the innate immune-metabolic response, by impacting glucose, lipid, and cholesterol homeostasis. The study examines whether y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb905a114ec7602ef5bba1d22d9b003
https://pure.qub.ac.uk/en/publications/226a0171-119a-481d-b580-a8f94834df1d

Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis

Autor: Holly Davage, Barry Linnane, Hilary Cassidy, Anne Trappe, Seamas C. Donnelly, Sarah L. Doyle, Edward F. McKone, Judith A. Coppinger, Eugene T. Dillon, Rebecca Reilly, Zivile Useckaite, Jenny Lennon, David Matallanas, Kiva Brennan, Paul McNally, S. Carter, Mark Ward

Publikováno v: Thorax

RationaleMutations in the cystic fibrosis transmembrane regulator (CFTR) gene form the basis of cystic fibrosis (CF). There remains an important knowledge gap in CF as to how diminished CFTR activity leads to the dominant inflammatory response within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b84b8cae1ec85fdc8241f2e5a5b0113
https://doi.org/10.1136/thoraxjnl-2019-214027

Liraglutide Attenuates Preestablished Atherosclerosis in Apolipoprotein E–Deficient Mice via Regulation of Immune Cell Phenotypes and Proinflammatory Mediators

Autor: M. O'Reilly, Mary Barry, Eugene T. Dillon, Fiona C. McGillicuddy, Sean Curley, Stephen Sheehan, Gina M. Lynch, Robyn Bruen, Orina Belton, Eoin P. Brennan, Sarina Kajani

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 370:447-458

We have shown that the glucagon-like peptide-1 receptor agonist (GLP-1RA) liraglutide (Lir) inhibits development of early atherosclerosis in vivo by modulating immune cell function. We hypothesized that Lir could attenuate pre-established disease by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e112bde1ea6f6cbadfb65dc9fff8274
https://doi.org/10.1124/jpet.119.258343