Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Eugene O. Apostolov"'
Autor:
Ashutosh M Shukla, Chhanda Bose, Oleg K Karaduta, Eugene O Apostolov, Gur P Kaushal, Tariq Fahmi, Mark S Segal, Sudhir V Shah
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139226 (2015)
Cardiovascular disease is the largest cause of morbidity and mortality among patients with chronic kidney disease (CKD) and end-stage kidney disease, with nearly half of all deaths attributed to cardiovascular disease. Hydroxychloroquine (HCQ), an an
Externí odkaz:
https://doaj.org/article/6c5a2e4e0df641ff892847fe90d077bc
DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity
Autor:
Alexei G. Basnakian, Tariq Fahmi, Xiaoying Wang, Dmitry D. Zhdanov, Alena V. Savenka, Intisar Islam, Eugene O. Apostolov
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 8665, p 8665 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 22
International Journal of Molecular Sciences
Volume 21
Issue 22
Endonuclease-mediated DNA fragmentation is both an immediate cause and a result of apoptosis and of all other types of irreversible cell death after injury. It is produced by nine enzymes including DNase I, DNase 2, their homologs, caspase-activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cdacff489cc4ffd881c9eb45b2620a
https://www.mdpi.com/1422-0067/21/22/8665
https://www.mdpi.com/1422-0067/21/22/8665
Autor:
Tariq Fahmi, Eugene O. Apostolov, Xiaoying Wang, Dmitry D. Zhdanov, Alexei G. Basnakian, Sabzali Javadov, Sokolov Nn
Publikováno v:
DNA and Cell Biology. 34:316-326
Cells contain several apoptotic endonucleases, which appear to act simultaneously before and after cell death by destroying the host cell DNA. It is largely unknown how the endonucleases are being induced and whether they can regulate each other. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672bde35f0c57c70711cb0a94c9e3e13
https://doi.org/10.1089/dna.2014.2772
https://doi.org/10.1089/dna.2014.2772
Autor:
Xiaoyan Yin, Alexei G. Basnakian, Nicholas Braman, Sergey N. Kolomeichuk, Eugene O. Apostolov
Publikováno v:
Encyclopedia of Analytical Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::131d2ee9d4b7a6efde9c5eccc9da8a75
https://doi.org/10.1002/9780470027318.a9629
https://doi.org/10.1002/9780470027318.a9629
Autor:
Abolfazl Zarjou, József Balla, Deepak Darshan, Eugene O. Apostolov, Anupam Agarwal, Jill W. Verlander, Reny Joseph, Lukas C. Kühn, Paolo Arosio, Amie M. Traylor, Subhashini Bolisetty
Publikováno v:
Journal of Clinical Investigation. 123:4423-4434
Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity. The purpose of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c043713ed28874519be58824e0c43c22
https://doi.org/10.1172/jci67867
https://doi.org/10.1172/jci67867
Autor:
Sudhir V. Shah, Ercan Ok, Safia Nawaz, Alena V. Savenka, Samuel T. Burns, Alexei G. Basnakian, Eugene O. Apostolov
Publikováno v:
Journal of Atherosclerosis and Thrombosis. 20:878-892
Aim Both oxidized LDL and carbamylated LDL are considered important for initiating atherosclerosis in patients with end-stage kidney disease through vascular endothelial cell dysfunction or injury. However their effects on each other and their relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8bd7f898919c263c1cfd090589c66b
https://doi.org/10.5551/jat.14035
https://doi.org/10.5551/jat.14035
Autor:
Eugene O. Apostolov, Alexie G. Basnakian, Jacqueline Tilak, Michael K. Shaw, Sudhir V. Shah, Joshua Kachner, Peter A. McCullough, Krittapoom Akrawinthawong
Publikováno v:
Cardiorenal Medicine. 3:7-16
Background: Open heart surgery with cardiopulmonary bypass is recognized as a common cause of acute kidney injury (AKI). The conventional biomarker creatinine is not sensitive enough to detect AKI until a significant decline in renal filtration has o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe4c62c6117df28990aafa61f08d8d4
https://doi.org/10.1159/000346815
https://doi.org/10.1159/000346815
Autor:
Sudhir V. Shah, Marina V. Mikhailova, Alexei G. Basnakian, Xiaoying Wang, Wilson M. Alobuia, Debarti Ray, Eugene O. Apostolov
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 300:H1997-H2004
End-stage kidney disease is a terminal stage of chronic kidney disease, which is associated with a high incidence of cardiovascular disease. Cardiovascular disease frequently results from endothelial injury caused by carbamylated LDL (cLDL), the prod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2576e7b84c425bd0d1e67eca62336eb5
https://doi.org/10.1152/ajpheart.01311.2010
https://doi.org/10.1152/ajpheart.01311.2010
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 29:1622-1630
Objective— Carbamylated LDL (cLDL) has been recently shown to have robust proatherogenic effects on human endothelial cells in vitro, suggesting cLDL may have a significant role in atherosclerosis in uremia. The current study was designed to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f210ae4ffd57f97cc1d14fbbde26e49a
https://doi.org/10.1161/atvbaha.109.189795
https://doi.org/10.1161/atvbaha.109.189795
Publikováno v:
Journal of Renal Nutrition. 18:65-69
Objective Urea undergoes a spontaneous, nonenzymatic transformation to cyanate, the active part of which is isocyanic acid, which can cause modifications of a variety of proteins in a process called carbamylation. We postulated that, in patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9a156645a42b52029bffd958415a7d
https://doi.org/10.1053/j.jrn.2007.10.014
https://doi.org/10.1053/j.jrn.2007.10.014