Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eugene L. Inman"'
Autor:
Liam C. Feely, Matthew H. Hulbert, Alton D Johnson, Eugene L. Inman, Albert S. Kearney, James N. Michaels, Elena Zour, Michael B. Mitchell
Publikováno v:
Journal of Pharmaceutical Innovation. 3:227-248
“The manufacture and use of a drug product, including its components, necessarily entail some degree of risk.”—International Conference for Harmonization (ICH) Q9. This paper examines the role of risk management in pharmaceutical product develo
Publikováno v:
Journal of Chromatographic Science. 28:578-583
The identification of related substances in pharmaceutical products is generally incomplete during the initial stages of chromatographic method development. Absorbance ratioing, by simultaneously monitoring the column effluent at two wavelengths and
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 8:513-520
An LC method is described for the determination of EDTA in vancomycin formulations. EDTA is complexed with iron and the Fe(EDTA)− complex is separated from vancomycin components on a reversed-phase column using an ion pair mobile phase. Quantitatio
Autor:
Eugene L. Inman
Publikováno v:
Journal of Chromatography A. 410:363-372
A gradient high-performance liquid chromatographic method for the determination of vancomycin related substances is described. This method was developed to profile vancomycin, co-fermentation products, and degradation products. The resultant chromato
Autor:
James D. Winefordner, Eugene L. Inman
Publikováno v:
Analytical Chemistry. 54:2018-2022
Constant energy synchronous luminescence has been developed to improve the selectivity of luminescence techniques. If the authors scan the excitation and emission monochromators simultaneously, synchronized so that a constant energy difference is mai
Publikováno v:
Spectrochimica Acta Part A: Molecular Spectroscopy. 39:245-250
Correlation techniques are applied to synchronous luminescence spectroscopy for parameter optimization. The synchronous process is mathematically similar to the correlation definition with each correlation point representing the integration of a sync
Publikováno v:
Analytical Chemistry. 58:2156-2160
Autor:
Eugene L. Inman, James D. Winefordner
Publikováno v:
Analytica Chimica Acta. 141:241-254
Constant energy synchronous luminescence spectroscopy is extended to low temperature conditions for the determination of polynuclear aromatic hydrocarbons. Low-temperature constant energy synchronous luminescence spectroscopy implements a constant en
Publikováno v:
Analytica Chimica Acta. 131:187-194
The analytical figures of merit for fluorescence of sixty polynuclear aromatic hydrocarbons are presented. The limits of detection for most of the compounds are below 50 ng ml-1 and the average relative standard deviation at 1 μg ml-1 for each compo