Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Eugene J. Eisenberg"'
Autor:
Yasaman Barekatain, Sunada Khadka, Kristen Harris, Jorge Delacerda, Victoria C. Yan, Ko-Chien Chen, Cong-Dat Pham, Md. Nasir Uddin, Rony Avritcher, Eugene J. Eisenberg, Raghu Kalluri, Steven W. Millward, Florian L. Muller
Publikováno v:
Analytical Chemistry. 94:10045-10053
The phosphonate group is a key pharmacophore in many anti-viral, anti-microbial, and anti-neoplastic drugs. Due to its high polarity and short retention time, detecting and quantifying such phosphonate-containing drugs with LC/MS-based methods is cha
Autor:
Pedro A. Piedra, Dorothy Agnes Theodore, Robert Jordan, Sangi Michael, Michel Perron, Kirsten M. Stray, Eugene J. Eisenberg, Richard L. Mackman, Brian E. Gilbert, Geoffery L. Toms, Gary Lee, April Kinkade, Tomas Cihlar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:1264-1273
Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections in infants and young children. In addition, RSV causes significant morbidity and mortality in hospitalized elderly and immunocompromised patients. Currently, o
Autor:
Jason W. Chien, Laurel J. Gershwin, Anne Carey, Richard L. Mackman, Eugene J. Eisenberg, Michel Perron, Sandy Lewis, Robert Jordan, Heather A. McEligot, Robert G. Strickley, Mark L Anderson, Nicole E. Behrens, Matt X. Shao, Tomas Cihlar
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 8
Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and pneumonia in infants. Effective treatment for RSV infection is a significant unmet medical need. While new RSV therapeutics are now in development, there are very few animal
Autor:
Anne Carey, Kirsten M. Stray, Brian E. Gilbert, Pedro A. Piedra, Dorothy Agnes Theodore, Kerim Babaoglu, Jay P. Parrish, Manoj C. Desai, Lijun Zhang, April Kinkade, Hai Yang, Dharmaraj Samuel, Oliver L. Saunders, Constantine G. Boojamra, Jaclyn Hayes, Robert Jordan, Sangi Michael, Eugene J. Eisenberg, David Sperandio, Dustin Siegel, Richard L. Mackman, Hui Hon Chung, Quynh Iwata, Tomas Cihlar, Michel Perron, Gary Lee, Robert G. Strickley
Publikováno v:
Journal of Medicinal Chemistry. 58:1630-1643
GS-5806 is a novel, orally bioavailable RSV fusion inhibitor discovered following a lead optimization campaign on a screening hit. The oral absorption properties were optimized by converting to the pyrazolo[1,5-a]-pyrimidine heterocycle, while potenc
Autor:
Yan Xin, John Ling, Jeffrey A. Silverman, Jason W. Chien, Eugene J. Eisenberg, Bernard P. Murray, Winnie Weng
Publikováno v:
Journal of clinical pharmacology. 58(6)
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections in young children. Presatovir (previously GS-5806) is a novel, orally administered RSV fusion inhibitor with a favorable safety profile and proven antiviral effi
Autor:
Yan Xin, Seth Toback, Jonna Weston, Jeffrey Silverman, Srini Ramanathan, Eugene J. Eisenberg, Jason W. Chien, Krysia Grycz, Winnie Weng, Bernard P. Murray
Publikováno v:
Open Forum Infectious Diseases. 2
Autor:
Florence Myrick, Katyna Borroto-Esoda, Eugene J. Eisenberg, Loren Y. Olson, Michael D. Miller, Adrian S. Ray, Jennifer E. Vela, Arnold Fridland
Publikováno v:
Antiviral Therapy. 10:451-457
Objective An anti-HIV regimen composed of the nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) tenofovir (TFV) disoproxil fumarate (TDF), abacavir (ABC) and lamivudine (3TC) has performed poorly in patients. This study evaluated the com
Autor:
John H. Huffman, Eugene J Eisenberg, Robert W. Sidwell, Kevin W. Bailey, Paul A Bemis, Min-Hui Wong
Publikováno v:
Antiviral Chemistry and Chemotherapy. 10:187-193
Experiments were done to determine how an alteration of the treatment schedule of 5 or 32 mg/kg/day per os (p.o.) doses of GS 4104 [the ethyl ester prodrug of the neuraminidase inhibitor (3R, 4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cylohexene
Autor:
Eugene J. Eisenberg, Kenneth C. Cundy
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 716:267-273
GS4071 is a potent inhibitor of influenza neuraminidase. A precolumn fluorescence derivatization HPLC method is described for the analysis of GS4071 in rat plasma. Plasma samples were subjected to solid-phase extraction on C18 extraction columns. Aft
Autor:
Ming S. Chen, Weixing Li, Dirk B. Mendel, James R. Merson, Eugene J. Eisenberg, Choung U. Kim, Matthew A. Williams, Kenneth C. Cundy, Lijun Zhang, Clive Sweet, Norbert Bischofberger, Kenneth J. Jakeman, Willard Lew, Paul A. Escarpe
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:647-653
GS 4071 is a potent carbocyclic transition-state analog inhibitor of influenza virus neuraminidase with activity against both influenza A and B viruses in vitro. GS 4116, the guanidino analog of GS 4071, is a 10-fold more potent inhibitor of influenz