Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Eugene Goldwasser"'
Publikováno v:
Annals of the New York Academy of Sciences. 77:551-573
Publikováno v:
Blood. 96:491-497
Hypoxia is a strong stimulus for the transcription of a set of genes, including erythropoietin and vascular endothelial growth factor. Here we report on the cloning, functional significance, and expression of a complementary DNA (cDNA) that is involv
Publikováno v:
Cell Biochemistry and Biophysics. 30:153-166
The cellular site of erythropoietin (epo) production within the mammalian kidney is still not completely understood. In the present study, we examined the expression of epo mRNA in microdissected rat nephron segments by RT-PCR after induction of epo
Autor:
Hugh B. Black, Eric C. Svensson, Sandeep K. Tripathy, Eugene Goldwasser, Zengping Hao, Debra L. Dugger, Jeffrey M. Leiden, Lien Chu
Publikováno v:
Human Gene Therapy. 8:1797-1806
Erythropoietin (Epo)-responsive anemia is a debilitating complication of chronic renal failure and human immunodeficiency virus (HIV) infection that effects more than 150,000 Americans. Patients with Epo-responsive anemias are currently treated with
Autor:
Eugene Goldwasser, Charles K.-H. Kung
Publikováno v:
Proteins: Structure, Function, and Genetics. 28:94-98
Urinary and recombinant human erythropoietin differ with respect to ease of iodination, inactivation by iodination, second derivative and circular dichroic spectra, rate of inactivation by trypsin and glycosylation pattern. All of these differences a
Autor:
Madhu Gupta, Eugene Goldwasser
Publikováno v:
Nucleic Acids Research. 24:4768-4774
Transcription of the erythropoietin (epo) gene is regulated in response to tissue hypoxia. In this study we show that constructs containing 117 bp of the epo promoter sequence cloned upstream of a luciferase reporter, respond to hypoxia when transfec
Autor:
Eugene Goldwasser, Huai Lin, Mohammad A. Haidar, Armand B. Glassman, Michael J. Keating, Maher Albitar, Yun Yang, Francisco Loya
Publikováno v:
Scopus-Elsevier
Erythropoietin (EPO) plays a key role in erythropoiesis and is expressed predominantly in the fetal liver and in the adult kidney. The EPO gene is up-regulated at the transcriptional level under hypoxic/anemic conditions. We studied the role of the 5
Publikováno v:
Scopus-Elsevier
Results on the localization of erythropoietin (Epo) synthesis in renal cells have been contradictory, implicating either interstitial or tubular cells. We fused the lacZ gene to a 7-kb DNA fragment of the mouse Epo gene encompassing a portion of the