Recombination-Independent Recognition of DNA Homology for Repeat-Induced Point Mutation (RIP) Is Modulated by the Underlying Nucleotide Sequence.

Autor: Eugene Gladyshev, Nancy Kleckner

Publikováno v: PLoS Genetics, Vol 12, Iss 5, p e1006015 (2016)

Haploid germline nuclei of many filamentous fungi have the capacity to detect homologous nucleotide sequences present on the same or different chromosomes. Once recognized, such sequences can undergo cytosine methylation or cytosine-to-thymine mutati

Externí odkaz: https://doaj.org/article/0bde23be5596434cbc2291c0d419df9e

Direct Homologous dsDNA–dsDNA Pairing: How, Where, and Why?

Autor: Eugene Gladyshev, Tinh-Suong Nguyen, Alexey K. Mazur

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2020, 432, pp.737-744. ⟨10.1016/j.jmb.2019.11.005⟩
Journal of Molecular Biology, 2020, 432, pp.737-744. ⟨10.1016/j.jmb.2019.11.005⟩
Journal of Molecular Biology, Elsevier, 2019, ⟨10.1016/j.jmb.2019.11.005⟩

The ability of homologous chromosomes (or selected chromosomal loci) to pair specifically in the apparent absence of DNA breakage and recombination represents a prominent feature of eukaryotic biology. The mechanism of homology recognition at the bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be6a2416c1e4a88e97eac62d9f514483
https://doi.org/10.1016/j.jmb.2019.11.005

Recombination-independent recognition of DNA homology for meiotic silencing in Neurospora crassa

Autor: Nicholas Rhoades, Tinh-Suong Nguyen, Guillaume Witz, Germano Cecere, Thomas Hammond, Alexey K. Mazur, Eugene Gladyshev

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (33), pp.e2108664118
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (33), pp.e2108664118

Pairing of homologous chromosomes represents a critical step of meiosis in nearly all sexually reproducing species. While in some organisms meiotic pairing requires programmed DNA breakage and recombination, in many others it engages homologous chrom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c5431a05a72954e3adcee31a318a88b
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261429

Regulation of DIM-2-dependent repeat-induced point mutation (RIP) by the recombination-independent homologous DNA pairing in Neurospora crassa

Autor: Alexey K. Mazur, T.-S. Nguyen, Eugene Gladyshev, F. Carlier

Repeat-induced point mutation (RIP) is a genetic process that creates cytosine-to-thymine (C-to-T) transitions in duplicated genomic sequences in fungi. RIP detects duplications irrespective of their origin, particular sequence, coding capacity, or g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c172907d1144caef345fb930dcef0a77
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261442/file/2021.04.05.438447v1.full.pdf

Partition of Repeat-Induced Point Mutations Reveals Structural Aspects of Homologous DNA-DNA Pairing

Autor: Alexey K. Mazur, Eugene Gladyshev

Publikováno v: Biophysical Journal
Biophysical Journal, Biophysical Society, 2018, 115 (4), pp.605-615. ⟨10.1016/j.bpj.2018.06.030⟩
Biophysical Journal, 2018, 115 (4), pp.605-615. ⟨10.1016/j.bpj.2018.06.030⟩

International audience; In some fungi, a premeiotic process known as repeat-induced point mutation (RIP) can accurately identify and mutate nearly all gene-sized DNA repeats present in the haploid germline nuclei. Studies in Neurospora crassa have su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67879aa544e70305792224a6ff4f69aa
https://doi.org/10.1016/j.bpj.2018.06.030