Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Eugene F Douglass"'
Autor:
Prabhjot S. Mundi, Filemon S. Dela Cruz, Adina Grunn, Daniel Diolaiti, Audrey Mauguen, Allison R. Rainey, Kristina Guillan, Armaan Siddiquee, Daoqi You, Ronald Realubit, Charles Karan, Michael V. Ortiz, Eugene F. Douglass, Melissa Accordino, Suzanne Mistretta, Frances Brogan, Jeffrey N. Bruce, Cristina I. Caescu, Richard D. Carvajal, Katherine D. Crew, Guarionex Decastro, Mark Heaney, Brian S. Henick, Dawn L. Hershman, June Y. Hou, Fabio M. Iwamoto, Joseph G. Jurcic, Ravi P. Kiran, Michael D. Kluger, Teri Kreisl, Nicole Lamanna, Andrew B. Lassman, Emerson A. Lim, Gulam A. Manji, Guy M. McKhann, James M. McKiernan, Alfred I. Neugut, Kenneth P. Olive, Todd Rosenblat, Gary K. Schwartz, Catherine A. Shu, Michael B. Sisti, Ana Tergas, Reena M. Vattakalam, Mary Welch, Sven Wenske, Jason D. Wright, Peter Canoll, Hanina Hibshoosh, Kevin Kalinsky, Mahalaxmi Aburi, Peter A. Sims, Mariano J. Alvarez, Andrew L. Kung, Andrea Califano
Publikováno v:
Cancer Discovery. :OF1-OF22
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies to predict tumor sensitivity to a comprehensive repertoire of clin
Autor:
Hongxu Ding, Eugene F. Douglass, Adam M. Sonabend, Angeliki Mela, Sayantan Bose, Christian Gonzalez, Peter D. Canoll, Peter A. Sims, Mariano J. Alvarez, Andrea Califano
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protei
Externí odkaz:
https://doaj.org/article/3934038bb326419f98860258816b7ced
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Index of Supplementary Data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400192d080ba228dd2401397762ff34b
https://doi.org/10.1158/2159-8290.22541971.v1
https://doi.org/10.1158/2159-8290.22541971.v1
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Supplementary Table 3: Transcriptomic analyses of the human patient samples A. TCGA Interactome B. SU2C Interactome C. Protein activity TCGA D. Protein Activity SU2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50152ab5715db26bd60d40e0922dd5e7
https://doi.org/10.1158/2159-8290.22541959
https://doi.org/10.1158/2159-8290.22541959
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b855720c962afe23f44290b02652b77
https://doi.org/10.1158/2159-8290.c.6549772
https://doi.org/10.1158/2159-8290.c.6549772
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Detailed Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4df22845dfdcb9a0c8be4fd4916ec0
https://doi.org/10.1158/2159-8290.22541974
https://doi.org/10.1158/2159-8290.22541974
Autor:
Cory Abate-Shen, Andrea Califano, Michael M. Shen, Mark A. Rubin, Mariano J. Alvarez, Eva Corey, Luca Zanella, Timur Mukhammadov, Stephanie N. Afari, Jaime Y. Kim, Sergey Pampou, Ronald Realubit, Charles Karan, Chee Wai Chua, Antonina Mitrofanova, Simone de Brot, Antonio Rodriguez-Calero, Maho Shibata, Florencia Picech, Eugene F. Douglass, Min Zou, Francisca Nunes de Almeida, Juan Martín Arriaga, Alessandro Vasciaveo
Figure S1: Genomic alterations in prostate cancer represented in the GEMMs (related to Fig. 2). Figure S2: Additional phenotypic analyses of the GEMMs (related to Fig. 2). Figure S3: Phenotypic analysis of allograft and organoid models (related to Fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dadb434fc053ed576194fbc4dad00257
https://doi.org/10.1158/2159-8290.22541968
https://doi.org/10.1158/2159-8290.22541968
Publikováno v:
ChemBioChem.
Autor:
Alessandro Vasciaveo, Juan Martín Arriaga, Francisca Nunes de Almeida, Min Zou, Eugene F. Douglass, Florencia Picech, Maho Shibata, Antonio Rodriguez-Calero, Simone de Brot, Antonina Mitrofanova, Chee Wai Chua, Charles Karan, Ronald Realubit, Sergey Pampou, Jaime Y. Kim, Stephanie N. Afari, Timur Mukhammadov, Luca Zanella, Eva Corey, Mariano J. Alvarez, Mark A. Rubin, Michael M. Shen, Andrea Califano, Cory Abate-Shen
Publikováno v:
Cancer discovery.
Prioritizing treatments for individual patients with cancer remains challenging, and performing coclinical studies using patient-derived models in real time is often unfeasible. To circumvent these challenges, we introduce OncoLoop, a precision medic
Autor:
Eugene F. Douglass Jr., Chad J. Miller
Ternary-complex directed enzyme catalysis underlies a vast array of biological processes and several clinical therapies including growth hormones, interferon, and heparin. Recently, interest in ternary catalysis drugs has increased significantly with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6f87117d91b8c2c0aa05bcf8738467
https://doi.org/10.33774/chemrxiv-2021-wgn82-v2
https://doi.org/10.33774/chemrxiv-2021-wgn82-v2