Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Eugene C. Petrella"'
Autor:
Jennifer Lattanze, Tianbao Lu, Karen L. Milkiewicz, Bruce L. Grasberger, Theodore E. Carver, Louis V. LaFrance, Daniel J. Parks, Kannan Ramachandren, Varsha Gupta, Raul R. Calvo, Diane M. Maguire, Eugene C. Petrella, Maxwell D. Cummings
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:765-770
A library of 1,4-benzodiazepine-2,5-diones was screened for binding to the p53-binding domain of HDM2 using Thermofluor ® , a miniaturized thermal denaturation assay. The hits obtained were shown to bind to HDM2 in the p53-binding pocket using a flu
Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
Autor:
Tianbao Lu, Jennifer Lattanze, Ingrid Deckman, Marie Zhang, Bruce L. Grasberger, Carl L. Manthey, and Christopher J. Molloy, John C. Spurlino, Diane M. Maguire, Eugene C. Petrella, Kannan Ramachandren, Holly K. Koblish, Shuyuan Zhao, Bruce E. Tomczuk, Gwendolyn R. Bylebyl, Louis V. LaFrance, Carsten Schubert, Daniel J. Parks, Karen L. Milkiewicz, Carol F. Franks, Theodore E. Carver, Roger F. Bone, Anna C. Maroney, Maxwell D. Cummings, Raul R. Calvo, W. Michael Avondale Pantoliano
Publikováno v:
Journal of Medicinal Chemistry. 48:909-912
HDM2 binds to an alpha-helical transactivation domain of p53, inhibiting its tumor suppressive functions. A miniaturized thermal denaturation assay was used to screen chemical libraries, resulting in the discovery of a novel series of benzodiazepined
Autor:
Lei Jin, Scott Pluskey, Katherine J. Seidl, Joan C. Gorga, Eugene C. Petrella, Pramod Pandey, Susan M. Cantin, David T. Weaver, James E. Strickler, Michael J. Rynkiewicz, Robert E. Babine
Publikováno v:
Journal of Biological Chemistry. 279:42818-42825
The ZAP-70 tyrosine kinase plays a critical role in T cell activation and the immune response and therefore is a logical target for immunomodulatory therapies. Although the crystal structure of the tandem Src homology-2 domains of human ZAP-70 in com
Autor:
Hartmut Juhl, Nai-Kong V. Cheung, Reinhard Bredehorst, Eugene C. Petrella, Carl-Wilhelm Vogel
Publikováno v:
Immunobiology. 197:444-459
Insufficient numbers of antigen molecules and heterogeneity of antigen expression on tumor cells are major factors limiting the immunotherapeutic potential of the few clinically useful monoclonal antibodies capable of mediating complement cytotoxicit
Autor:
Thomas D. Pollard, Apostolos G. Gittis, Shonda A. Leonard, Eugene C. Petrella, Eaton E. Lattman
Publikováno v:
Nature Structural & Molecular Biology. 4:369-373
Actophorin is a member of the actin-depolymerizing factor/cofilin family. It severs act in filaments and sequesters actin monomers. The crystal structure of actophorin will help to elucidate actin–ADF/cofilin interactions.
Publikováno v:
Biochemistry. 35:16535-16543
The binding to poly(L-proline) is used for the affinity purification of profilins, but little is known about the structural and thermodynamic aspects of the interaction. We used changes in the intrinsic fluorescence of profilin, CD spectroscopy, and
Publikováno v:
Analytical Biochemistry. 226:342-348
Supported hybrid bilayer membranes (HBM) composed of a monolayer of phospholipid and a monolayer of alkanethiol associated with a thin gold film on glass are useful as model lipid bilayer membranes for studying membrane receptor-ligand and cell-cell
Autor:
David Schwalb, Ivan Cornella-Taracido, John A. Tallarico, Scott M. Brittain, Markus Schirle, Edmund Harrington, Eugene C. Petrella
Publikováno v:
Methods in Molecular Biology ISBN: 9781617793363
Quantitative chemoproteomics has recently emerged as an experimental approach to determine protein interaction profiles of small molecules in a given cell line or tissue. In contrast to standard biochemical and biophysical kinase assays, application
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::324a394d396969f3d1ea75495f1f2ed1
https://doi.org/10.1007/978-1-61779-337-0_11
https://doi.org/10.1007/978-1-61779-337-0_11
Autor:
Matthew D. Shair, D. Ryan Anderson, Shuichi Okubo, Minpei Kuroda, Kousei Shimada, Kevin C. Fortner, John A. Tallarico, David Schwalb, Jason Murphy, Yoshihiro Mimaki, Eugene C. Petrella, Markus Schirle, Kittikhun Wangkanont, Chikako Kikuchi, Ivan Cornella-Taracido, Anthony W. G. Burgett, Thomas B. Poulsen
Publikováno v:
Burgett, A W G, Bjørnskov Poulsen, T, Wangkanont, K, Anderson, D R, Kikuchi, C, Shimada, K, Okubo, S, Fortner, K C, Mimaki, Y, Kuroda, M, Schirle, M, Murphy, J P, Schwalb, D J, Petrella, E C, Cornella-Taracido, I, Tallarico, J A & Shair, M D 2011, ' Natural products reveal cancer cell dependence on oxysterol-binding proteins ', Nature Chemical Biology, vol. 7, pp. 639-647 . https://doi.org/10.1038/nchembio.625
Cephalostatin 1, OSW-1, ritterazine B and schweinfurthin A are natural products that potently, and in some cases selectively, inhibit the growth of cultured human cancer cell lines. The cellular targets of these small molecules have yet to be identif
Autor:
Carl-Wilhelm Vogel, Hartmut Juhl, Eugene C. Petrella, Reinhard Bredehorst, Nai-Kong V. Cheung
Publikováno v:
Molecular Immunology. 27:957-964
Only a few monoclonal antibodies mediate complement lysis of tumor cells, but for several antibodies it has been demonstrated that a complement-activating function can be introduced by covalent coupling of cobra venom factor (CVF), a non-toxic glycop