Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Eugene C. Chen"'
Autor:
Donglu Zhang, Bin Ma, Peter S. Dragovich, Li Ma, Shu Chen, Eugene C. Chen, Xiaofen Ye, Joyce Liu, Jennifer Pizzano, Elizabeth Bortolon, Emily Chan, Xing Zhang, Yi-Chen Chen, Elizabeth S. Levy, Robert L. Yauch, S. Cyrus Khojasteh, Cornelis E. C. A. Hop
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-14 (2024)
Abstract Background Proteolysis-targeting chimeras (PROTACs) are being developed for therapeutic use. However, they have poor pharmacokinetic profiles and their tissue distribution kinetics are not known. Methods A typical von Hippel-Lindau tumor sup
Externí odkaz:
https://doaj.org/article/d01205e636654c30909bf31520a8b785
Autor:
Robert S. Jones, Eugene C. Chen
Publikováno v:
Drug Transporters. :497-514
Autor:
Eugene C. Chen, Pär Matsson, Mina Azimi, Xujia Zhou, Niklas Handin, Sook Wah Yee, Per Artursson, Kathleen M. Giacomini
Publikováno v:
Pharmaceutical Research. 39:1599-1613
Introduction The organic cation transporter 3 (OCT3, SLC22A3) is ubiquitously expressed and interacts with a wide array of compounds including endogenous molecules, environmental toxins and prescription drugs. Understudied as a determinant of pharmac
Autor:
Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C Chen, Qi Luo, Ling Zou, Meiling Piao, Arias Mifune, Ligong Chen, Meredith E Calvert, Sarah King, Frode Norheim, Janna Abad, Ronald M Krauss, Kathleen M Giacomini
Publikováno v:
PLoS Biology, Vol 16, Iss 4, p e2002907 (2018)
A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association stu
Externí odkaz:
https://doaj.org/article/b0a8de10439546bea60bb2c9df501479
Autor:
Kathleen M. Giacomini, Sook W. Yee, Megan L. Koleske, Ling Zou, Pär Matsson, Eugene C. Chen, Deanna L. Kroetz, Miles A. Miller, Elnaz Gozalpour, Xiaoyan Chu
Publikováno v:
Clinical pharmacology and therapeutics, vol 112, iss 3
Enabled by a plethora of new technologies, research in membrane transporters has exploded in the past decade. The goal of this state-of-the-art article is to describe recent advances in research on membrane transporters that are particularly relevant
Autor:
Victor Yip, Eugene C. Chen, T. Noelle Lombana, Daniel D. Bravo, Sharon Viajar, Sophia Lee, C. Andrew Boswell, Wilson Phung, Marissa L. Matsumoto, Jianyong Wang, Avinash Gill, Christoph Spiess, Farzam Farahi, Julie A. Zorn, Wendy Sandoval, Sharmila Rajan, Alberto Estevez, Danielle Mandikian, Claudio Ciferri
Publikováno v:
mAbs
IgA antibodies have broad potential as a novel therapeutic platform based on their superior receptor-mediated cytotoxic activity, potent neutralization of pathogens, and ability to transcytose across mucosal barriers via polymeric immunoglobulin rece
Autor:
Fang Ma, Srikumar Sahasranaman, Jialin Mao, Rui Zhu, Edna F. Choo, Yuan Chen, Lichuan Liu, Eugene C. Chen
Publikováno v:
Biopharmaceutics & Drug Disposition. 39:420-430
GDC-0810 was under development as an oral anti-cancer drug for the treatment of estrogen receptor-positive breast cancer as a single agent or in combination. In vitro data indicated that GDC-0810 is a potent inhibitor of OATP1B1/1B3. To assess clinic
Autor:
Laurent Salphati, Jonathan Cheong, Shu Zhang, Fabio Broccatelli, Eugene C Chen, Liling Liu, Emile Plise, Jamie Jorski, Katherine Gaffney, Kayla K Umemoto, Buyun Chen
Publikováno v:
Molecular Pharmaceutics. 15:5103-5113
Permeability assays are commonly conducted with Madin-Darby canine kidney (MDCK) cells to predict the intestinal absorption of small-molecule drug candidates. In addition, MDCK cells transfected to overexpress efflux transporters are often used to id
Autor:
Marilyn M. Giacomini, Xiaomin Liang, Huan-Chieh Chien, Meiling Piao, Jia Hao, Jolyn Twelves, Kathleen M. Giacomini, Eugene C. Chen, Sook Wah Yee, Eve-Irene Lepist, Adrian S. Ray
Publikováno v:
Molecular Pharmaceutics. 12:4301-4310
The biguanide metformin is widely used as first-line therapy for the treatment of type 2 diabetes. Predominately a cation at physiological pH's, metformin is transported by membrane transporters, which play major roles in its absorption and dispositi
Autor:
Eugene C. Chen, Kathleen M. Giacomini, Fariba Goodarzian, Brian Weiss, Ethan G. Geier, Katherine K. Matthay, Randall A. Hawkins, Hollie A. Jackson, Susan L. Cohn, M. Meaghan Granger, Gregory A. Yanik, Xiaodong Yang, Jesse Courtier, Araz Marachelian, Steven G. DuBois, Denice D. Tsao-Wei, Julie R. Park, Judith G. Villablanca, S. Groshen, Daphne A. Haas-Kogan, Scarlett Czarnecki, Hiroyuki Shimada
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 21, iss 12
Purpose: 131I-metaiodobenzylguanidine (MIBG) is a radiopharmaceutical with activity in neuroblastoma. Vorinostat is a histone deacetylase inhibitor that has radiosensitizing properties. The goal of this phase I study was to determine the MTDs of vori