Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Eugene C. Amparo"'
Autor:
Eugene C. Amparo, Srinivas K. Chunduru, Ariamala Gopalsamy, Christopher A. Benetatos, Lori E. Miller, Tandy L. Draper, Christopher J. Burns, Matthew G. LaPorte, Lara K. Leister, Torsten Herbertz, Dorothy C. Young, Stephen M. Condon, Blackledge Charles W, Gerry Rhodes, Alison R. Hussey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2968-2973
We describe the structure-activity relationship of the C1-group of pyrano[3,4-b]indole based inhibitors of HCV NS5B polymerase. Further exploration of the allosteric binding site led to the discovery of the significantly more potent compound 12.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82b0bf920d396980908e52cb23485ed
https://doi.org/10.1016/j.bmcl.2010.03.002
https://doi.org/10.1016/j.bmcl.2010.03.002
Autor:
Matthew R. Wright, John M. Fevig, Richard S. Alexander, Mimi L. Quan, Ruth R. Wexler, Patrick Y.S. Lam, Bruce J. Aungst, Pancras C. Wong, Joseph M. Luettgen, Shuaige Wang, Donald J. P. Pinto, Robert M. Knabb, Michael J. Orwat, Angela Smallwood, Joseph Cacciola, Eugene C. Amparo, Karen A. Rossi, Li Liang
Publikováno v:
Journal of Medicinal Chemistry. 44:566-578
Factor Xa (fXa) plays a critical role in the coagulation cascade, serving as the point of convergence of the intrinsic and extrinsic pathways. Together with nonenzymatic cofactor Va and Ca2+ on the phospholipid surface of platelets or endothelial cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1baab668ee8ada600c3efb24122f955c
https://doi.org/10.1021/jm000409z
https://doi.org/10.1021/jm000409z
Autor:
Vicki L. Nienaber, Eugene C. Amparo
Publikováno v:
Journal of the American Chemical Society. 118:6807-6810
The 2.0 A resolution crystal structure of the retro-binding natural product nazumamide A (NAZA) complexed with human thrombin is presented. The crystal structure shows that the retro-binding nazumamide A is noncleavable and extends into the prime end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e43aa7ffee2a96d6d2a13ee7e11c0500
https://doi.org/10.1021/ja960045t
https://doi.org/10.1021/ja960045t
Autor:
Diane Cebzanov, C. Faust, D. Ortlip, Lessen Thomas A, L. Leister, Thomas R. Bailey, Dorothy C. Young, Christopher J. Burns, Srinivas K. Chunduru, Eugene C. Amparo, Theodore J. Nitz, M.G. LaPorte
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(1)
A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0790457da65da0dd2bbe76c1098483c9
https://pubmed.ncbi.nlm.nih.gov/16260131
https://pubmed.ncbi.nlm.nih.gov/16260131
Autor:
Ruth R. Wexler, Eugene C. Amparo, Joseph M. Luettgen, Celia Dominguez, Daniel E. Duffy, Pancras C. Wong, Richard S. Alexander, Qi Han, Robert A. Galemmo, Robert M. Knabb, Jeongsook M. Park
Publikováno v:
Bioorganicmedicinal chemistry letters. 9(7)
Thrombin, a serine protease, plays a central role in the initiation of thrombotic events. We report the design, synthesis, and antithrombotic efficacy of XU817 (7), a nonpeptide 5-(amidino) indole thrombin inhibitor. Utilizing the co-crystal structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0db365673a0287a9a6c94c01800d5bc
https://pubmed.ncbi.nlm.nih.gov/10230612
https://pubmed.ncbi.nlm.nih.gov/10230612