Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Eugene Bragin"'
Autor:
Kathy E. Raven, Eugene Bragin, Beth Blane, Danielle Leek, Narender Kumar, Paul A. Rhodes, David A. Enoch, Rachel Thaxter, Nicholas M. Brown, Julian Parkhill, Sharon J. Peacock
Publikováno v:
mSphere, Vol 7, Iss 6 (2022)
ABSTRACT Genomic epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) could transform outbreak investigations, but its clinical introduction is hampered by the lack of automated data analysis tools to rapidly and accurately define trans
Externí odkaz:
https://doaj.org/article/5cc05981254c445b8df27c652f9a60cd
Autor:
Romney M. Humphries, Eugene Bragin, Julian Parkhill, Grace Morales, Jonathan E. Schmitz, Paul A. Rhodes
The declining cost of performing bacterial whole-genome sequencing (WGS) coupled with the availability of large libraries of sequence data for well-characterized isolates have enabled the application of machine-learning (ML) methods to the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f5c66bf274985a48c1360d232615a59
https://www.repository.cam.ac.uk/handle/1810/349213
https://www.repository.cam.ac.uk/handle/1810/349213
Autor:
Narender Kumar, Paul A. Rhodes, Kathy E. Raven, Beth Blane, Julian Parkhill, Sharon J. Peacock, Eugene Bragin, Danielle Leek, Nicholas M. Brown
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives The genetic prediction of phenotypic antibiotic resistance based on analysis of WGS data is becoming increasingly feasible, but a major barrier to its introduction into routine use is the lack of fully automated interpretation tools. Here,
Autor:
Beth Blane, Kathy E. Raven, Eugene Bragin, Sharon J. Peacock, Danielle Leek, Julian Parkhill, Francesc Coll, Narender Kumar
Publikováno v:
Microbial Genomics
Bacterial sequencing will become increasingly adopted in routine microbiology laboratories. Here, we report the findings of a technical evaluation of almost 800 clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates, in which we sought
Autor:
R. Thaxter, David A Enoch, Kathy E. Raven, Beth Blane, Danielle Leek, Narender Kumar, Nicholas M. Brown, Julian Parkhill, Eugene Bragin, Paul A. Rhodes, Sharon J. Peacock
Publikováno v:
Journal of Clinical Microbiology
Genomic surveillance that combines bacterial sequencing and epidemiological information will become the gold standard for outbreak detection, but its clinical translation is hampered by the lack of automated interpretation tools. We performed a prosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd8ef323b84cd3968c673f817f7e34e
https://www.repository.cam.ac.uk/handle/1810/296289
https://www.repository.cam.ac.uk/handle/1810/296289
Autor:
Michael Parker, Helen V. Firth, Anna Middleton, Katherine I. Morley, Caroline F. Wright, Eugene Bragin, Matthew E. Hurles
Publikováno v:
Journal of Medical Genetics
Health-related results that are discovered in the process of genomic research should only be returned to research participants after being clinically validated and then delivered and followed up within a health service. Returning such results may be
Autor:
Anna Middleton, Caroline F. Wright, Katherine I. Morley, Michael Parker, Helen V. Firth, Eugene Bragin, Matthew E. Hurles
Publikováno v:
European Journal of Human Genetics
Genome-wide sequencing in a research setting has the potential to reveal health-related information of personal or clinical utility for the study participant. There is increasing pressure to return research findings to participants that may not be re
Autor:
Michael Parker, Caroline F. Wright, G. Jawahar Swaminathan, Philip Jones, Stephen Clayton, Alejandro Sifrim, Daniel A. King, Netravathi Krishnappa, Laura E Mason, Vijaya Parthiban, Katherine I. Morley, Margriet van Kogelenberg, Matthew E. Hurles, David R. FitzPatrick, Jeremy F. McRae, Eugene Bragin, Elena Prigmore, Helen V. Firth, Kirsty Ambridge, Wendy D Jones, Diana Rajan, Ray Miller, Daniel M Barrett, Tanya Bayzetinova, A. Paul Bevan, Nigel P. Carter, Susan M. Gribble, Jeffrey C. Barrett, Tomas W Fitzgerald, Eleni A. Chatzimichali, Adrian Tivey, Anna Middleton
Publikováno v:
Lancet
Wright, C F, Fitzgerald, T W, Jones, W D, Clayton, S, McRae, J F, van Kogelenberg, M, King, D A, Ambridge, K, Barrett, D M, Bayzetinova, T, Bevan, A P, Bragin, E, Chatzimichali, E A, Gribble, S, Jones, P, Krishnappa, N, Mason, L E, Miller, R, Morley, K I, Parthiban, V, Prigmore, E, Rajan, D, Sifrim, A, Swaminathan, G J, Tivey, A R, Middleton, A, Parker, M, Carter, N P, Barrett, J C, Hurles, M E, FitzPatrick, D R, Firth, H V 2015, ' Genetic diagnosis of developmental disorders in the DDD study : a scalable analysis of genome-wide research data ', Lancet, vol. 385, no. 9975, pp. 1305-1314 . https://doi.org/10.1016/S0140-6736(14)61705-0
Europe PubMed Central
Wright, C F, Fitzgerald, T W, Jones, W D, Clayton, S, McRae, J F, van Kogelenberg, M, King, D A, Ambridge, K, Barrett, D M, Bayzetinova, T, Bevan, A P, Bragin, E, Chatzimichali, E A, Gribble, S, Jones, P, Krishnappa, N, Mason, L E, Miller, R, Morley, K I, Parthiban, V, Prigmore, E, Rajan, D, Sifrim, A, Swaminathan, G J, Tivey, A R, Middleton, A, Parker, M, Carter, N P, Barrett, J C, Hurles, M E, FitzPatrick, D R, Firth, H V 2015, ' Genetic diagnosis of developmental disorders in the DDD study : a scalable analysis of genome-wide research data ', Lancet, vol. 385, no. 9975, pp. 1305-1314 . https://doi.org/10.1016/S0140-6736(14)61705-0
Europe PubMed Central
BACKGROUND: Human genome sequencing has transformed our understanding of genomic variation and its relevance to health and disease, and is now starting to enter clinical practice for the diagnosis of rare diseases. The question of whether and how som
Autor:
Eugene Bragin, Matthew E. Hurles, Caroline F. Wright, G. Jawahar Swaminathan, Eleni A. Chatzimichali, A. Paul Bevan, Helen V. Firth
Publikováno v:
Nucleic Acids Research
The DECIPHER database (https://decipher.sanger.ac.uk/) is an accessible online repository of genetic variation with associated phenotypes that facilitates the identification and interpretation of pathogenic genetic variation in patients with rare dis
Publikováno v:
Social Science Research
Highlights • We created a novel, online survey including 10 short films. • The extensive survey validation process involved 19 iterations before the final survey was ready. • Focussing on the survey design paid dividends in high response rate a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4f2fbc9c2a85770725454f7c2caf62
https://ora.ox.ac.uk/objects/uuid:cdaf768c-0a1a-43ba-bd1f-64fff2f2fd4a
https://ora.ox.ac.uk/objects/uuid:cdaf768c-0a1a-43ba-bd1f-64fff2f2fd4a