Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Eugene B. Grant"'
Autor:
John G. Geisler, Yin Liang, Robyn Williams, Gary W. Caldwell, Keith T. Demarest, Margery A. Connelly, Eugene B. Grant, Matthew J. Todd, Ioanna P. Petrounia, Brett P. Monia, Hossein Askari, Sanjay Bhanot, Jenson Qi, Geoffrey T. Struble, Micheal D. Gaul, Wensheng Lang, Charles Smith, Shariff Bayoumy, Selyna Mai, Ping Wang
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1106-1116 (2012)
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triglyceride (TG) synthesis. There are two isoforms, DGAT1 and DGAT2, with distinct protein sequences and potentially different physiological functions. To date, the ability to determi
Autor:
Tobias Schmid, Mark J. Macielag, Armin Roessler, Xun Li, Roger Faessler, Michele A. Weidner-Wells, Ronald K. Russell, Scott Youells, Eugene B. Grant
Publikováno v:
Organic Preparations and Procedures International. 42:151-160
7-[4-(2-Amino-1-chloroethylidene)piperidin-1-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4- oxo-1,4-dihydroquinoline-3-carboxylic acid (10) is a potent bacterial topoisomerase inhibitor. In vitro, compoun...
Autor:
Karen Bush, Barbara D. Foleno, Darren Abbanat, Deodialsingh Guiadeen, Eugene B. Grant, Mark J. Macielag
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1929-1933
A new series of erythromycin A derivatives, the 6-O-heteroarylcarbamoyl-11,12-lactoketolides, with activity against macrolide-resistant streptococci, are described. Structurally, these macrolide antibiotics are characterized by a heteroaryl side chai
Autor:
Deodialsingh Guiadeen, Eugene B. Grant, Jesse M. Weiss, Sigmond G. Johnson, Stuart Hayden, William V. Murray, Mark J. Macielag, Shawn Branum
Publikováno v:
Tetrahedron Letters. 46:2731-2735
A short, concise synthesis of a novel series of (9S)-9-alkyl-9-hydroxyerythromycin A derivatives and their corresponding ketolides, is described. The key chemical transformation is a stereoselective addition of organomagnesium or organolithium agents
Autor:
Karen Bush, Jamese J. Hilliard, Eugene B. Grant, Mark J. Macielag, Michele A. Weidner-Wells, Steven David Paget, Brian J. Morrow, William V. Murray, Raul Goldschmidt, Barbara D. Foleno, Xiaoqing Xu, Xiaodong Xu, Shu-Chen Lin
Publikováno v:
Bioorganicmedicinal chemistry letters. 24(23)
Novel antibacterial fluoroquinolone agents bearing a 4-alkylidenylpiperidine 7-position substituent are active against quinolone-susceptible and quinolone-resistant gram-positive bacteria, including Streptococcus pneumoniae and MRSA. Analogs 22b, 23c
Autor:
William D. Wulff, Michael J. Fumo, Mark C. Whitcomb, Siu Man Yeung, Jianming Bao, Eugene B. Grant, Douglas P. Heller
Publikováno v:
Journal of the American Chemical Society. 118:2166-2181
The first examples of the reactions of Fischer carbene complexes with 1,3-butadiynes are reported. These reactions are of interest since they provide new methods for the synthesis of acetylenic substituted arenes and also for the synthesis of biaryls
Autor:
Arnold L. Rheingold, Jianming Bao, Alexander C. Rob, Siu Man Yeung, Mark C. Whitcomb, Eugene B. Grant, William D. Wulff, James B. Dominy, Michael J. Fumo, Robert L. Ostrander
Publikováno v:
Journal of the American Chemical Society. 118:3392-3405
Two methods for the synthesis of vaulted biaryls were developed involving the reactions of carbene complexes with alkynes and the [2 + 2] cycloaddition of ketenes. The final step in the synthesis of 3,3‘-diphenyl-[2,2‘-binaphthalene]-1,1‘-diol
Autor:
Robert S. Coleman, Eugene B. Grant
Publikováno v:
Journal of the American Chemical Society. 117:10889-10904
Autor:
Eugene B. Grant, Robert S. Coleman
Publikováno v:
Tetrahedron Letters. 35:8341-8344
Mitsunobu inversion of 1,1′-binaphthalenediol 3 with benzoic acid was studied, and the success of the reaction was found to depend upon quantitative formation of bis-oxyphosphonium salt 6 at −23 °C, prior to S N 2 displacement at 25 °C.
Autor:
Robert S. Coleman, Eugene B. Grant
Publikováno v:
Tetrahedron Letters. 34:2225-2228
Application of an oxidative copper(I)-mediated biaryl cross-coupling protocol to the synthesis of highly oxygenated, differentially substituted 1-1′-binaphthalenes related to the perylenequinone calphostin C is detailed.