Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Eugene A. Mueller"'
Autor:
Raobo Xu, Liqing He, Vatsalya Vatsalya, Xipeng Ma, Seongho Kim, Eugene G. Mueller, Wenke Feng, Craig J. McClain, Xiang Zhang
Publikováno v:
American journal of physiology. Gastrointestinal and liver physiology.
Excess alcohol intake causes millions of deaths annually worldwide. Asymptomatic early-stage alcohol-associated liver disease (ALD) is easily overlooked, and ALD is usually only diagnosed in more advanced stages. We explored the possibility of using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220708ff97a55229a9e9c7e65c55cf1e
https://pubmed.ncbi.nlm.nih.gov/36513601
https://pubmed.ncbi.nlm.nih.gov/36513601
Publikováno v:
Protein Science. 25:1737-1743
4-Thiouridine at position 8 in prokaryotic tRNA serves as a photosensor for near-UV light, and the posttranscriptional conversion of uridine to 4-thiouridine is catalyzed by the 4-thiouridine synthetases (s4US, also named ThiI), which fall into two c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55feb82712efa779c5f85a9841bd50a
https://doi.org/10.1002/pro.2965
https://doi.org/10.1002/pro.2965
Publikováno v:
Methods in enzymology. 596
The synthesis of specifically deuterated uridine, its incorporation into an RNA oligonucleotide substrate, and the use of the labeled substrate to determine the deuterium kinetic isotope effect for the reaction catalyzed by the pseudouridine synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::089a26ec17c12731eadab30f154eb17c
https://pubmed.ncbi.nlm.nih.gov/28911783
https://pubmed.ncbi.nlm.nih.gov/28911783
The synthesis of specifically deuterated uridine, its incorporation into an RNA oligonucleotide substrate, and the use of the labeled substrate to determine the deuterium kinetic isotope effect for the reaction catalyzed by the pseudouridine synthase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3df763a05e4d5cf384ba6f8e5447737
https://doi.org/10.1016/bs.mie.2017.07.018
https://doi.org/10.1016/bs.mie.2017.07.018
Publikováno v:
Journal of the American Chemical Society
The pseudouridine synthases isomerize (U) in RNA to pseudouridine (Ψ), and the mechanism that they follow has long been a question of interest. The recent elucidation of a product of the mechanistic probe 5-fluorouridine that had been epimerized to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9896598ee40e04279492a685d8039e
https://pubmed.ncbi.nlm.nih.gov/27292228
https://pubmed.ncbi.nlm.nih.gov/27292228
Publikováno v:
Protein science : a publication of the Protein Society. 25(9)
4-Thiouridine at position 8 in prokaryotic tRNA serves as a photosensor for near-UV light, and the posttranscriptional conversion of uridine to 4-thiouridine is catalyzed by the 4-thiouridine synthetases (s(4) US, also named ThiI), which fall into tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afe632b483f47c5ca9dd8b31b9f4cd4d
https://pubmed.ncbi.nlm.nih.gov/27293139
https://pubmed.ncbi.nlm.nih.gov/27293139
Metabolomic Analysis of the Effects of Polychlorinated Biphenyls in Nonalcoholic Fatty Liver Disease
Autor:
Banrida Wahlang, Seongho Kim, Xiaoli Wei, K. Cameron Falkner, Eugene G. Mueller, Russell A. Prough, Matthew C. Cave, Xinmin Yin, Craig J. McClain, Xue Shi, Xiang Zhang
Publikováno v:
Journal of Proteome Research. 11:3805-3815
Polychlorinated Biphenyls (PCBs) are persistent organic pollutants and have been associated with abnormal liver enzymes and suspected non-alcoholic fatty liver disease (NAFLD), obesity, and the metabolic syndrome in epidemiological studies. In epidem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991e6495ec7e58424a364880f4790704
https://doi.org/10.1021/pr300297z
https://doi.org/10.1021/pr300297z
Autor:
Eugene G. Mueller, Edward J. Miracco
Publikováno v:
Journal of the American Chemical Society. 133:11826-11829
The pseudouridine synthase TruB handles 5-fluorouridine in RNA as a substrate, converting it into two isomeric hydrated products. Unexpectedly, the two products differ not in the hydrated pyrimidine ring but in the pentose ring, which is epimerized t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaeeba92456c103469599eb376e1a32
https://doi.org/10.1021/ja201179f
https://doi.org/10.1021/ja201179f
Publikováno v:
Biochemistry. 50:426-436
RNA containing 5-fluorouridine (F(5)U) had previously been used to examine the mechanism of the pseudouridine synthase TruA, formerly known as pseudouridine synthase I [Gu et al. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 14270-14275]. From that work,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec989df43b461a3c276958f3dfb9c73
https://doi.org/10.1021/bi101737z
https://doi.org/10.1021/bi101737z
Autor:
Junjun Chen, Eugene G. Mueller, Christopher S. Hamilton, Charmaine Hoang, Caroline A. Vizthum, Jason M. Kandel, Adrian R. Ferré-D'Amaré
Publikováno v:
Molecular Cell. 24(4):535-545
Summary RluA is a dual-specificity enzyme responsible for pseudouridylating 23S rRNA and several tRNAs. The 2.05 A resolution structure of RluA bound to a substrate RNA comprising the anticodon stem loop of tRNA Phe reveals that enzyme binding induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9b15a93fbba92d9d95fffc1cd53e1d