Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Eugene A. Konorev"'
Autor:
Melissa S. Cobb, Shixin Tao, Katherine Shortt, Magdy Girgis, Jeryl Hauptman, Jill Schriewer, Zaphrirah Chin, Edward Dorfman, Kyle Campbell, Daniel P. Heruth, Ralph V. Shohet, Buddhadeb Dawn, Eugene A. Konorev
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 323:H1091-H1107
Many anticancer therapies cause serious cardiovascular complications that degrade quality of life and cause early mortality in treated patients. Specifically, doxorubicin is known as an effective anticancer agent that causes cardiomyopathy in treated
Publikováno v:
The FASEB Journal. 35
Autor:
Zuyue Sun, Ralph V. Shohet, Eugene A. Konorev, Jerry W. Marlin, Jill Schriewer, Mingxin Tang, Frederick R. Taylor
Publikováno v:
Journal of Molecular and Cellular Cardiology. 90:129-138
Elevated ALK4/5 ligands including TGF-β2 and activins have been linked to cardiovascular remodeling and heart failure. Doxorubicin (Dox) is commonly used as a model of cardiomyopathy, a condition that often precedes cardiovascular remodeling and hea
Publikováno v:
Redox report : communications in free radical research. 1(3)
Publikováno v:
Journal of Proteomics. 74:683-697
Doxorubicin-induced cardiomyopathy in cancer patients is well established. The proposed mechanism of cardiac damage includes generation of reactive oxygen species, mitochondrial dysfunction and cardiomyocyte apoptosis. Exposure of adult rat cardiomyo
Publikováno v:
Journal of Molecular and Cellular Cardiology. 112:143
Autor:
Balaraman Kalyanaraman, Narayan G. Avadhani, Satish Srinivasan, Karunakaran Chandran, Raymond Q. Migrino, Deepika Aggarwal, Joy Joseph, Donna McAllister, Eugene A. Konorev, William E. Antholine, Jacek Zielonka
Publikováno v:
Biophysical Journal. 96(4):1388-1398
Doxorubicin (DOX) is used for treating various cancers. Its clinical use is, however, limited by its dose-limiting cardiomyopathy. The exact mechanism of DOX-induced cardiomyopathy still remains unknown. The goals were to investigate the molecular me
Publikováno v:
Free Radical Biology and Medicine. 45:1723-1728
A proposed mechanism for the cardiotoxicity of doxorubicin (DOX) involves apoptosis in cardiomyocytes. In the study described here, we investigated the molecular basis for the differences in DOX-induced toxicity in adult rat cardiomyocytes (ARCM), ne
Autor:
Jeannette Vasquez-Vivar, Balaraman Kalyanaraman, Eugene A. Konorev, Irina A. Ionova, Jacek Zielonka, Jennifer Whitsett, Yang Shi, Galen M. Pieper
Publikováno v:
Free Radical Biology and Medicine. 45:994-1001
There is evidence that nitric oxide (NO) formation in adult cardiomyocytes stimulated with lipopolysaccharide (LPS) is not commensurate with iNOS levels. Tetrahydrobiopterin (BH(4)) is a key factor in the stabilization and NO production by iNOS homod
Autor:
Shasi V. Kalivendi, Sonya Cunningham, Eugene H. Kaji, Balaraman Kalyanaraman, Eugene A. Konorev, Sravan K. Vanamala, Joy Joseph
Publikováno v:
Biochemical Journal. 389:527-539
Doxorubicin (DOX), a widely used antitumour drug, causes dose-dependent cardiotoxicity. Cardiac mitochondria represent a critical target organelle of toxicity during DOX chemotherapy. Proposed mechanisms include generation of ROS (reactive oxygen spe