Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Eugene A. Kapp"'
Autor:
Saw Yen Ow, Eugene A. Kapp, Vesna Tomasetig, Anton Zalewski, Jason Simmonds, Con Panousis, Michael J. Wilson, Andrew D. Nash, Matthias Pelzing
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTHageman factor (FXII) is an essential component in the intrinsic coagulation cascade and a therapeutic target for the prophylactic treatment of hereditary angioedema (HAE). CSL312 (garadacimab) is a novel high-affinity human antibody capable
Externí odkaz:
https://doaj.org/article/0c07c3f8278b450db8ee8af9dbb53b06
Autor:
Michael J. Coffey, Laura F. Dagley, Simona Seizova, Eugene A. Kapp, Giuseppe Infusini, David S. Roos, Justin A. Boddey, Andrew I. Webb, Christopher J. Tonkin
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Toxoplasma gondii infects approximately 30% of the world’s population, causing disease primarily during pregnancy and in individuals with weakened immune systems. Toxoplasma secretes and exports effector proteins that modulate the host dur
Externí odkaz:
https://doaj.org/article/ea7a3291199047328178731b63d09cfa
Autor:
Marine Gros, Elodie Segura, Derek C. Rookhuizen, Blandine Baudon, Sandrine Heurtebise-Chrétien, Nina Burgdorf, Mathieu Maurin, Eugene A. Kapp, Richard J. Simpson, Patrycja Kozik, Jose A. Villadangos, Mathieu J.M. Bertrand, Marianne Burbage, Sebastian Amigorena
Publikováno v:
Cell Reports
Cell Reports, 2022, 40 (7), pp.111205. ⟨10.1016/j.celrep.2022.111205⟩
CELL REPORTS
Cell Reports, 2022, 40 (7), pp.111205. ⟨10.1016/j.celrep.2022.111205⟩
CELL REPORTS
International audience; Despite its crucial role in initiation of cytotoxic immune responses, the molecular pathways underlying antigen cross-presentation remain incompletely understood. The mechanism of antigen exit from endocytic compartments into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4f6dae263c114b5590c8084942422e6
https://cnrs.hal.science/hal-03877482
https://cnrs.hal.science/hal-03877482
Autor:
Eugene A. Kapp, Craig A. Hutton, Soumya Mukherjee, Blaine R. Roberts, Mengxuan Fang, Romain Huguet, Varsha J. Thombare, W. Mei Kok, Gavin E. Reid
Publikováno v:
Analytical Chemistry. 91:12129-12133
Dityrosine cross-linking of Aβ peptides and α-synuclein is increasingly becoming recognized as a biomarker of neuropathological diseases. However, there remains a need for the development of analytical methods that enable the specific and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4853c1b038ecc1093907b01643cf5702
https://doi.org/10.1021/acs.analchem.9b02986
https://doi.org/10.1021/acs.analchem.9b02986
Autor:
Nir S. Gov, Gili Ben-Nissan, Ziv Porat, Dana Yaffe, Tal Block Temin, Michal Sharon, Ron Rotkopf, Raya Sorkin, Irit Rosenhek-Goldian, Daniel Alfandari, Teresa Carvalho, Ori Avinoam, Eugene A. Kapp, Debakshi Mullick, Gijs J.L. Wuite, Neta Regev-Rudzki, Yifat Ofir-Birin, Tamar Ziv, Matthew A. Pimentel, Giulia Bergamaschi, Ariel Rudik, Thomas Nebl, Mattia I. Morandi, Shimrit Malihi, Or-Yam Revach, Xavier Sisquella, Sidney R. Cohen, Elya Dekel, Ido Azuri, Paula Abou Karam, Yael Ohana Daniel
Publikováno v:
Nature Communications, 12(1):1172, 1-19. Nature Publishing Group
Nature Communications
Dekel, E, Yaffe, D, Rosenhek-Goldian, I, Ben-Nissan, G, Ofir-Birin, Y, Morandi, M I, Ziv, T, Sisquella, X, Pimentel, M A, Nebl, T, Kapp, E, Ohana Daniel, Y, Karam, P A, Alfandari, D, Rotkopf, R, Malihi, S, Temin, T B, Mullick, D, Revach, O Y, Rudik, A, Gov, N S, Azuri, I, Porat, Z, Bergamaschi, G, Sorkin, R, Wuite, G J L, Avinoam, O, Carvalho, T G, Cohen, S R, Sharon, M & Regev-Rudzki, N 2021, ' 20S proteasomes secreted by the malaria parasite promote its growth ', Nature Communications, vol. 12, no. 1, 1172, pp. 1-19 . https://doi.org/10.1038/s41467-021-21344-8
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Dekel, E, Yaffe, D, Rosenhek-Goldian, I, Ben-Nissan, G, Ofir-Birin, Y, Morandi, M I, Ziv, T, Sisquella, X, Pimentel, M A, Nebl, T, Kapp, E, Ohana Daniel, Y, Karam, P A, Alfandari, D, Rotkopf, R, Malihi, S, Temin, T B, Mullick, D, Revach, O Y, Rudik, A, Gov, N S, Azuri, I, Porat, Z, Bergamaschi, G, Sorkin, R, Wuite, G J L, Avinoam, O, Carvalho, T G, Cohen, S R, Sharon, M & Regev-Rudzki, N 2021, ' 20S proteasomes secreted by the malaria parasite promote its growth ', Nature Communications, vol. 12, no. 1, 1172, pp. 1-19 . https://doi.org/10.1038/s41467-021-21344-8
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Mature red blood cells (RBCs) lack internal organelles and canonical defense mechanisms, making them both a fascinating host cell, in general, and an intriguing choice for the deadly malaria parasite Plasmodium falciparum (Pf), in particular. Pf, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e1a42c6a1d186f80e14ae5e2384ee8
https://doi.org/10.1038/s41467-021-21344-8
https://doi.org/10.1038/s41467-021-21344-8
Sulindac modulates secreted protein expression from LIM1215 colon carcinoma cells prior to apoptosis
Colorectal cancer (CRC) is a major cause of mortality in Western populations. Growing evidence from human and rodent studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) cause regression of existing colon tumors and act as effective ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2aa9eb5cc69d6cfe9a280f39c5bf89
The secretopeptidome comprises endogenous peptides derived from proteins secreted into the tumour microenvironment through classical and non-classical secretion. This study characterised the low-Mr (< 3 kDa) component of the human colon tumour (LIM12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14fabc15b6df4f6f094a86e68d5ff50
Autor:
Yepy H Rustam, Iris K. L. Tan, Eugene A. Kapp, Jonathan P. Bernardini, Grant Dewson, Peter M. Colman, Nicholas A. Smith, Jarrod J. Sandow, Jason M. Brouwer, M.J. Roy, Andrew I. Webb, Gavin E. Reid, Brian J. Smith, Peter E. Czabotar, Angus D. Cowan, Jacqueline M. Gulbis, James M. Murphy, Ahmad Wardak
Publikováno v:
Nature structuralmolecular biology. 27(11)
BAK and BAX are essential mediators of apoptosis that oligomerize in response to death cues, thereby causing permeabilization of the mitochondrial outer membrane. Their transition from quiescent monomers to pore-forming oligomers involves a well-char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d09b3adc9911ffb81c34d497964c1f7
https://pubmed.ncbi.nlm.nih.gov/32929280
https://pubmed.ncbi.nlm.nih.gov/32929280
Autor:
Blaine R. Roberts, Eugene A. Kapp, Larissa Lago, Aimee L. Dordevic, Anna M. Raines, Roger A. Sunde, Bárbara Rita Cardoso
Publikováno v:
The Journal of Nutritional Biochemistry. 98:108831
There is a U-shaped dose-response between selenium (Se) status and health outcomes, but underlying metabolic processes are unclear. This study aims to identify candidate proteins in liver regulated by dietary Se, ranging from deficiency to toxic. Mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66197f4a713cc622024dab4f4d7d6026
https://doi.org/10.1016/j.jnutbio.2021.108831
https://doi.org/10.1016/j.jnutbio.2021.108831
Autor:
Ashley I. Bush, Craig A. Hutton, Berin A. Boughton, Kevin J. Barnham, Yury V. Vasil’ev, Amber Lothian, Eugene A. Kapp, Joseph S. Beckman, Blaine R. Roberts, Somdatta Ghosh Dey, Soumya Mukherjee, Colin L. Masters, W. Mei Kok, Anne M. Roberts
Publikováno v:
Analytical Chemistry. 89:6136-6145
The use of mass spectrometry coupled with chemical cross-linking of proteins has become a powerful tool for proteins structure and interactions studies. Unlike structural analysis of proteins using chemical reagents specific for lysine or cysteine re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc22ec8668e62014e02df47d5a77b587
https://doi.org/10.1021/acs.analchem.7b00941
https://doi.org/10.1021/acs.analchem.7b00941