Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Eugene A. Coats"'
Autor:
Eugene A. Coats, H. P. Cordes, Klaus-J. Schaper, Joachim K. Seydel, Emmanuel Polymeropoulos, Juergen Engel, B. Kutscher, Peter Emig
Publikováno v:
Journal of Medicinal Chemistry. 37:3016-3022
The synthesis of 2,3,6-triaminopyridine derivatives, representing a unique chemical structure for anticonvulsants, is described. The synthetic program was performed (a) to identify more potent analogs, (b) to determine structural properties controlli
Publikováno v:
ChemInform. 26
Some aspects of drug membrane interaction and its influence on drug transport, accumulation, efficacy and resistance have been discussed. The interactions manifest themselves macroscopically in changes in the physical and thermodynamic properties of
Publikováno v:
Quantitative Structure-Activity Relationships. 11:205-210
The importance of the interaction of drug molecules with membranes is discussed. The first two examples use the interaction of benzylpyrimidines with membranes of sensitive and resistant E. coli. This leads to a partial inactivation due to binding an
Publikováno v:
Chemistry and Molecular Aspects of Drug Design and Action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e663dee0699e43dbd5b029343ba2103c
https://doi.org/10.1201/9781420008272.ch23
https://doi.org/10.1201/9781420008272.ch23
Autor:
James J. Knittel, Eugene A. Coats
Publikováno v:
Quantitative Structure-Activity Relationships. 9:94-101
Quantitative structure-activity relationships for a series of N-(R-benzoyl)-glutamic acid α-alkylamides as cholecystokinin inhibitors have been elucidated. The relationships clearly define a hydrophobic binding pocket on the receptor which accomodat
Autor:
Eugene A. Coats
Publikováno v:
3D QSAR in Drug Design ISBN: 0792347919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e19371dc50cecf6e0d4f8581a7e9c466
https://doi.org/10.1007/0-306-46858-1_13
https://doi.org/10.1007/0-306-46858-1_13
Publikováno v:
Archiv der Pharmazie. 327(10)
Some aspects of drug membrane interaction and its influence on drug transport, accumulation, efficacy and resistance have been discussed. The interactions manifest themselves macroscopically in changes in the physical and thermodynamic properties of
Publikováno v:
Journal of enzyme inhibition. 6(4)
A series of N-substituted glucosamines has been designed, synthesized, and tested as inhibitors of yeast hexokinase. All derivatives exhibited competitive inhibition kinetics with respect to glucose. Quantitative structure-activity relationships were
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468458794
Many indole compounds, including dietary indoles such as indole-3-carbinol [I-3- C], have been shown to protect against chemical carcinogenesis (Wattenberg 1983) and chemically induced hepatotoxicity (Shertzer et al. 1987a, 1987b, 1988a). Such protec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15276de6c34de2ac9c97245beecde3d3
https://doi.org/10.1007/978-1-4684-5877-0_116
https://doi.org/10.1007/978-1-4684-5877-0_116
Autor:
Eugene A. Coats, Kishorkant J. Shah
Publikováno v:
Journal of Medicinal Chemistry. 20:1001-1006
Fifteen 7-substituted 4-hydroxyquinoline-3-carboxylic acids have been designed to minimize covariance between the physicochemical substituent parameters: pi, MR, and sigmap. The molecules have been synthesized and evaluated for their ability to inhib